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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 10
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Research Article

Distribution in female rats of an anaesthetic intravenous dose of 14C-propofol

P. J. Simons Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
I. D. Cockshott Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
E. J. Douglas Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
E. A. Gordon Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
S. Knott Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
&
R. J. Ruane Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Pages 1325-1335 | Received 02 Oct 1990, Accepted 01 Jun 1991, Published online: 22 Sep 2008

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A. Acco & A. Bracht. (2004) Transport, transformation and distribution space of propofol in the rat liver studied by means of the indicator-dilution technique. Xenobiotica 34:4, pages 317-334.
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D. MCKILLOP, M. J. WILD, C. J. BUTTERS & C. SIMCOCK. (1998) Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica 28:9, pages 845-853.
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I. D. Cockshott, E. J. Douglas, G. F. Plummer & P. J. Simons. (1992) The pharmacokinetics of propofol in laboratory animals. Xenobiotica 22:3, pages 369-375.
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P. J. Simons, I. D. Cockshott, E. J. Douglas, E. A. Gordon, S. Knott & R. J. Ruane. (1991) Species differences in blood profiles, metabolism and excretion of 14C-propofol after intravenous dosing to rat, dog and rabbit. Xenobiotica 21:10, pages 1243-1256.
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Articles from other publishers (17)

Luisa Gluth, Crista Ochsenfarth, Phuong Nam Viet Pham, Jan M. Wischermann, Thomas Komanek, Florian Roghmann & Ulrich H. Frey. (2023) Influence of the Anesthetic Technique on Circulating Extracellular Vesicles in Bladder Cancer Patients Undergoing Radical Cystectomy: A Prospective, Randomized Trial. Cells 12:20, pages 2503.
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Ricardo Jorge Dinis-Oliveira. (2018) Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects. BioMed Research International 2018, pages 1-16.
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Kellie A. Woll, Brian P. Weiser, Qiansheng Liang, Tao Meng, Andrew McKinstry-Wu, Benika Pinch, William P. Dailey, Wei Dong Gao, Manuel Covarrubias & Roderic G. Eckenhoff. (2015) Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition. ACS Chemical Neuroscience 6:6, pages 927-935.
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Liguo Wei, Hiroko Matsumoto & Hidenori Yamaguchi. (2012) Propofol attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production through p38 MAPK and SAPK/JNK in alveolar epithelial cells. Journal of Anesthesia 27:3, pages 366-373.
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Rasmus Jansson, Ulf Bredberg & Michael Ashton. (2008) Prediction of Drug Tissue to Plasma Concentration Ratios Using a Measured Volume of Distribution in Combination With Lipophilicity. Journal of Pharmaceutical Sciences 97:6, pages 2324-2339.
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W.-H. Chan, T.-L. Chen, R.-M. Chen, W.-Z. Sun & T.-H. Ueng. (2006) Propofol metabolism is enhanced after repetitive ketamine administration in rats: the role of cytochrome P-450 2B induction. British Journal of Anaesthesia 97:3, pages 351-358.
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Alison Li Lin, Nandita Shangari, Tom S. Chan, Diadelas Remirez & Peter J. O'Brien. (2006) Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time. Life Sciences 79:1, pages 21-29.
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Hirofumi HINO, Miki SAKAMOTO, Kazuko NAGANO, Jun SASANO, Harukazu NAGANO, Kazuhide UCHIDA & Takeshi TATEDA. (2006) Neuromuscular Blocking Effects of Propofol in Patients with Myasthenia Gravis. THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 26:2, pages 156-163.
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Alexandra Acco, Jurandir Fernando Comar & Adelar Bracht. (2004) Metabolic Effects of Propofol in the Isolated Perfused Rat Liver. Pharmacology and Toxicology 95:4, pages 166-174.
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C.H. Ting, R.H. Arnott, D.A. Linkens & A. Angel. (2004) Migrating from target-controlled infusion to closed-loop control in general anaesthesia. Computer Methods and Programs in Biomedicine 75:2, pages 127-139.
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Michelle G. Hawkins, Bonnie D. Wright, Peter J. Pascoe, Philip H. Kass, Lara K. Maxwell & Lisa A. Tell. (2003) Pharmacokinetics and anesthetic and cardiopulmonary effects of propofol in red-tailed hawks ( Buteo jamaicensis ) and great horned owls ( Bubo virginianus ). American Journal of Veterinary Research 64:6, pages 677-683.
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H. Ihmsen, A. Tzabazis, M. Schywalsky & H. Schwilden. (2002) Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effects. European Journal of Anaesthesiology 19:3, pages 177-188.
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Takumi Taniguchi, Ken Yamamoto, Nobuko Ohmoto, Keisuke Ohta & Tsutomu Kobayashi. (2000) Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. Critical Care Medicine 28:4, pages 1101-1106.
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E. Miller & G. R. Park. (2002) The effect of oxygen on propofol‐induced inhibition of microsomal cytochrome P450 3A4. Anaesthesia 54:4, pages 320-322.
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Chantal Le Guellec, Bruno Lacarelle, Pierre-Henri Villard, Huguette Point, Jacques Catalin & Alain Durand. (1995) Glucuronidation of Propofol in Microsomal Fractions from Various Tissues and Species Including Humans. Anesthesia & Analgesia 81:4, pages 855-861.
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Chantal Le Guellec, Bruno Lacarelle, Pierre-Henri Villard, Huguette Point, Jacques Catalin & Alain Durand. (1995) Glucuronidation of Propofol in Microsomal Fractions from Various Tissues and Species Including Humans. Anesthesia & Analgesia 81:4, pages 855-861.
Crossref
Ming-Hwang Shyr, Tung-Hu Tsai, Peter P.C. Tan, Chieh-Fu Chen & Samuel H.H. Chan. (1995) Concentration and regional distribution of propofol in brain and spinal cord during propofol anesthesia in the rat. Neuroscience Letters 184:3, pages 212-215.
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