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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 11
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Research Article

Species- and sex-related differences in the plasma clearance and metabolite formation of antipyrine. A comparative study in four animal species: Cattle, goat, rat and rabbit

R. F. Witkamp Department of Veterinary Basic Sciences, Division of Pharmacology, Pharmacy and Toxicology, P.O. Box 80176, 3508, TD, Utrecht, The Netherlands
,
J. A. C. M. Lohuis Department of Herd Health and Reproduction, P.O. Box 80176, 3508, TD, Utrecht, The Netherlands
,
S. M. Nijmeijer Department of Veterinary Basic Sciences, Division of Pharmacology, Pharmacy and Toxicology, P.O. Box 80176, 3508, TD, Utrecht, The Netherlands
,
H. J. Kolker Department of Veterinary Basic Sciences, Division of Pharmacology, Pharmacy and Toxicology, P.O. Box 80176, 3508, TD, Utrecht, The Netherlands
,
J. Noordhoek Research Institute for Toxicology, University of Utrecht, P.O. Box 80176, 3508, TD, Utrecht, The Netherlands
&
A. S. J. P. A. M. Van Miert Department of Veterinary Basic Sciences, Division of Pharmacology, Pharmacy and Toxicology, P.O. Box 80176, 3508, TD, Utrecht, The Netherlands
Pages 1483-1492 | Received 06 Dec 1990, Accepted 14 Jun 1991, Published online: 22 Sep 2008

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W. M. Zweers-zeilmaker, J. Batzias, R. F. M. Maas, G. J. Horbach, A. S. J. P. A. M. van Miert & R. F. Witkamp. (1996) In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): Substrate activities and effects of inducers. Xenobiotica 26:11, pages 1131-1141.
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M. Monshouwer, R. F. Witkamp, A. Pijpers, J. H. M. Verheijden & A. S. J. P. A. M. Van Miert. (1994) Dose-dependent pharmacokinetic interaction between antipyrine and paracetamol in vivo and in vitro when administered as a cocktail in pig. Xenobiotica 24:4, pages 347-355.
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G. A. E. Van't Klooster, F. M. A. Woutersen-Van Nijnanten, B. J. Blaauboer, J. Noordhoek & A. S. J. P. A. M. Van Miert. (1994) Applicability of cultured hepatocytes derived from goat, sheep and cattle in comparative drug metabolism studies. Xenobiotica 24:5, pages 417-428.
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M. Natsuhori, R. F. Witkamp, G. A. E. Van 'T Klooster & A. S. J. P. A. M. Van Miert. (1992) Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin. Xenobiotica 22:11, pages 1243-1250.
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Zhigang Shen, Ping Zhang, Xinyuan Xu, Xinru Wang, Zhiqiang Zhou & Donghui Liu. (2011) Gender-Related Differences in Stereoselective Degradation of Flutriafol in Rabbits. Journal of Agricultural and Food Chemistry 59:18, pages 10071-10077.
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S. MODRIC & M. MARTINEZ. (2011) Patient variation in veterinary medicine - Part II - Influence of physiological variables. Journal of Veterinary Pharmacology and Therapeutics 34:3, pages 209-223.
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Shayne Cox GadJan H. Beumer, Julie L. Eiseman & Merrill J. Egorin. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
J. Velík, V. Baliharová, L. Skálová, B. Szotáková, V. Wsól & J. Lamka. (2003) Stereospecific biotransformation of albendazole in mouflon and rat-isolated hepatocytes. Journal of Veterinary Pharmacology and Therapeutics 26:4, pages 297-302.
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Richard Czerniak. (2016) Gender-Based Differences in Pharmacokinetics in Laboratory Animal Models. International Journal of Toxicology 20:3, pages 161-163.
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A.VAN MIERT. (2001) A Horse is Not a Large Rat: Getting Toxicology into Perspective. The Veterinary Journal 161:3, pages 222-223.
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C. NEBBIA. (2001) Biotransformation Enzymes as Determinants of Xenobiotic Toxicity in Domestic Animals. The Veterinary Journal 161:3, pages 238-252.
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K JANUS & J ANTOSZEK. (2000) The effect of sex and age on caffeine pharmacokinetics in cattle. Research in Veterinary Science 69:1, pages 33-37.
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S.X. Jiang, J.E. Bayón, I. Ferre, X.Z. Mao & J. González-Gallego. (2000) Effect of experimental fasciolosis on antipyrine metabolism and clearance in water buffaloes. Veterinary Parasitology 88:3-4, pages 177-186.
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C. T. Eason, G. R. G. Wright & R. Gooneratne. (1999) Pharmacokinetics of antipyrine, warfarin and paracetamol in the brushtail possum. Journal of Applied Toxicology 19:3, pages 157-161.
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Saitoh, Kokue & Shimoda. (2002) The suppressive effects of lipopolysaccharide‐induced acute phase response on hepatic cytochrome P450‐dependent drug metabolism in rabbits. Journal of Veterinary Pharmacology and Therapeutics 22:2, pages 87-95.
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Ignacio Ferre, Pilar López, Francisco Antonio Rojo-Vásquez & Javier González-Gallego. (1996) Experimental ovine fasciolosis: antipyrine clearance as indicator of liver damage. Veterinary Parasitology 62:1-2, pages 93-100.
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Z. BEN‐ZVI, M. RUBIN, C. VAN CREVELD & R. YAGIL. (2008) Antipyrine disposition in the dehydrated camel. Journal of Veterinary Pharmacology and Therapeutics 18:2, pages 137-140.
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P. Delrat, S. Dupin, P. Galtier, M. Alvinerie, J.J. Voigt, A.E. Tufenkji, S. Saivin & G. Houin. (1994) Assessment of Hepatic Insufficiency Model in the Rabbit Using Carbon Tetrachloride Intoxication. Journal of Pharmaceutical Sciences 83:11, pages 1637-1642.
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R.F. Witkamp, H.J. Kolker, S.M. Nijmeijer, J. Noordhoek & A.S.J.P.A.M. van Miert. (1993) Selective changes in oxidative xenobiotic metabolism in vivo and in vitro after parenteral administration of recombinant bovine somatotrophin to rats. Research in Veterinary Science 55:1, pages 31-37.
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R. F. WITKAMP, S. M. NIJMEIJER, H.J. KOLKER, J. NOORDHOEK & A.S.J.P. A. M. VAN MIERT. (2008) Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in the dwarf goat. Journal of Veterinary Pharmacology and Therapeutics 16:2, pages 164-173.
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Gilbert O. Kokwaro, Sabariah Ismail, Anthony P. Glazier, Stephen A. Ward & Geoffrey Edwards. (1993) Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat. Biochemical Pharmacology 45:6, pages 1243-1249.
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