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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 11
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Research Article

Identification of a hydroxy metabolite of diflunisal in rat and human urine

J. I. Macdonald College of Pharmacy, University of Saskatchewan, Canada
,
R. G. Dickinson Department of Medicine, University of Queensland, Australia
,
R. S. Reid Department of Chemistry, University of Saskatchewan, Canada
,
R. W. Edom College of Pharmacy, University of Saskatchewan, Canada
,
A. R. King Department of Medicine, University of Queensland, Australia
&
R. K. Verbeeck College of Pharmacy, University of Saskatchewan, Canada
Pages 1521-1533 | Received 28 Jan 1991, Accepted 12 Jul 1991, Published online: 22 Sep 2008

Citations (11)

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Read on this site (3)

Frank J. Belas & Ian A. Blair. (2001) MASS SPECTROMETRY IN PHARMACEUTICAL ANALYSIS*. Journal of Liposome Research 11:4, pages 309-342.
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A. Bader, K. Zech, O. Crome, U. Christians, B. Ringe, R. Pichlmayr & K-Fr. Sewing. (1994) Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica 24:7, pages 623-633.
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R. G. Dickinson, R. K. Verbeeck & A. R. King. (1991) Absence of phenolic glucuronidation and enhanced hydroxylation of diflunisal in the homozygous Gunn rat. Xenobiotica 21:11, pages 1535-1546.
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Articles from other publishers (8)

Sándor Gonda, Attila Kiss-Szikszai, Zsolt Szűcs, Borbála Balla & Gábor Vasas. (2016) Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.. International Biodeterioration & Biodegradation 108, pages 115-121.
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Elisabeth Vinner & Daniel Mathieu. (2006) Analgésiques non morphiniques. Salicylés. EMC - Biologie Médicale 1:1, pages 1-8.
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R.G Dickinson, A.R King, M.A Kelly, I.A Kaltashov & C Fenselau. (1994) Excretion of 3-hydroxy-diflunisal as a monosulphate conjugate—identification using ESI-MS. Journal of Pharmaceutical and Biomedical Analysis 12:9, pages 1075-1078.
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Keizo Sato, Takeshi Kumazawa & Yoshinao Katsumata. (1994) On-line high-performance liquid chromatography-fast atom bombardment mass spectrometry in forensic analysis. Journal of Chromatography A 674:1-2, pages 127-145.
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I. A. Blair. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 41 84 .
Donata Favretto & Pietro Traldi. (1993) MS/MS applications in biological problems. Mass Spectrometry Reviews 12:5-6, pages 313-395.
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J. I. Macdonald, S. M. Wallace, V. Mahachai & R. K. Verbeeck. (1992) Both phenolic and acyl glucuronidation pathways of diflunisal are impaired in liver cirrhosis. European Journal of Clinical Pharmacology 42:5, pages 471-474.
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Andrew R. King & Ronald G. Dickinson. (1991) Studies on the reactivity of acyl glucuronides—I. Biochemical Pharmacology 42:12, pages 2289-2299.
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