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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 2
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Research Article

Disposition of bepridil in laboratory animals and man

W. N. Wu The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
J. F. Pritchard Glaxo Inc., 5 Moore Drive, Research Triangle Park, NC, 32, USA
,
K. T. Ng The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
J. F. Hills The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
J. A. Uetz The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
K. A. Yorgey The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
,
L. A. McKown The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA, 32, USA
&
P. J. O'neill Ethicon Inc., Somerville, NJ, 32, USA
 show all
Pages 153-169 | Received 22 Jan 1991, Accepted 16 Aug 1991, Published online: 22 Sep 2008

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W. N. Wu, J. F. Hills & R. S. Egan. (1994) Metabolism of xilobam in laboratory animals and man. Xenobiotica 24:7, pages 649-662.
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Chang Ren, Yao Wang, Mei Zhang, Dexuan Kong, Chen Ning, Yujie Cheng, Yueying Bian, Mengqi Sun, Shengdi Su, Yucong Wang, Yongjie Zhang, Yang Lu, Ning Li, Di Zhao & Xijing Chen. (2021) Characterization of Preclinical Pharmacokinetic Properties and Prediction of Human PK Using a Physiologically Based Pharmacokinetic Model for a Novel Anti-Arrhythmic Agent Sulcardine Sulfate. Pharmaceutical Research 38:11, pages 1847-1862.
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Courtney L. Finch, Julie Dyall, Shuang Xu, Elizabeth A. Nelson, Elena Postnikova, Janie Y. Liang, Huanying Zhou, Lisa Evans DeWald, Craig J. Thomas, Amy Wang, Xin Xu, Emma Hughes, Patrick J. Morris, Jon C. Mirsalis, Linh H. Nguyen, Maria P. Arolfo, Bryan Koci, Michael R. Holbrook, Lisa E. Hensley, Peter B. Jahrling, Connie Schmaljohn, Lisa M. Johansen, Gene G. Olinger, Joshua T. Schiffer & Judith M. White. (2021) Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo. Microorganisms 9:3, pages 566.
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Erol C. VatanseverKai S. YangAleksandra K. Drelich, Kaci C. KratchChia-Chuan ChoKempaiah Rayavara Kempaiah, Jason C. HsuDrake M. Mellott, Shiqing XuChien-Te K. Tseng & Wenshe Ray Liu. (2021) Bepridil is potent against SARS-CoV-2 in vitro. Proceedings of the National Academy of Sciences 118:10.
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Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha & Michael Martin. (2007) Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N -Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine) . Drug Metabolism and Disposition 35:6, pages 929-936.
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Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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Koegler Frank H.Cowley Michael A.. 2005. The Laboratory Primate. The Laboratory Primate 437 447 .
Iftekhar Mahmood, Martin David Green & J. Edward Fisher. (2003) Selection of the First-Time Dose in Humans: Comparison of Different Approaches Based on Interspecies Scaling of Clearance. The Journal of Clinical Pharmacology 43:7, pages 692-697.
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Iftekhar Mahmood. (2002) Interspecies Scaling: Predicting Oral Clearance in Humans. American Journal of Therapeutics 9:1, pages 35-42.
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W. N. Wu, G. W. Caldwell & J. A. Masucci. (2001) Evaluation of the absorption, excretion, and metabolism of the antihypertensive agent RWJ-26899 in male and female CR wistar rats and beagle dogs. European Journal of Drug Metabolism and Pharmacokinetics 26:3, pages 155-166.
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Ilkay Küçükgüzel, Mert Ülgen & John W Gorrod. (1999) In vitro hepatic microsomal metabolism of N-benzyl-N-methylaniline. Il Farmaco 54:5, pages 331-337.
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R. Wennig. 1996. Human Toxicology. Human Toxicology 25 236 .
Wu-Nan Wu & Martin S. Mutter. (1995) Biotransformation of linogliride, a hypoglycemic agent in laboratory animals and humans. Journal of Pharmaceutical and Biomedical Analysis 13:7, pages 857-867.
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Robert M. Johnson, Clemenceau Acquaye, Claude Féo & Sharada Sarnaik. (1994) Bepridil as an antisickling agent: Membrane internalization and cell rigidity. American Journal of Hematology 46:4, pages 310-318.
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