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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 2
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Research Article

Differentiation of cytochrome P-450 inducers on the basis of 7-alkoxycoumarin O-dealkylase activities

J. R. Fry Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
,
M. J. Garle Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
&
K. Lal Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
Pages 211-215 | Received 03 Jun 1991, Accepted 03 Oct 1991, Published online: 22 Sep 2008

Citations (13)

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J. R. Fry, A. H. Hammond, K. L. Jassi, A. E. Bass, G. Bruce, C. Laughton, P. N. Shaw, I. E. Bylov & S. M. Kovalenko. (2004) Selectivity of 7-alkoxycoumarins as probe substrates for rat hepatic cytochrome P450 forms is influenced by the substitution pattern on the coumarin nucleus. Xenobiotica 34:8, pages 707-722.
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M. J. GARLE, C. SINCLAIR, P. THURLEY & J. R. FRY. (1999) Haloalcohols deplete glutathione when incubated with fortified liver fractions. Xenobiotica 29:5, pages 533-545.
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Articles from other publishers (11)

Ann-Kathrin Loerracher & Thomas Braunbeck. (2020) Inducibility of cytochrome P450-mediated 7-methoxycoumarin-O-demethylase activity in zebrafish (Danio rerio) embryos. Aquatic Toxicology 225, pages 105540.
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Ali Mansour Giurnazi, Michael J Garle, Kishan Lal & Jeffrey R Fry. (1996) 7−Ethoxy−3,4−dimethylcoumarin: A Substrate for a Cytochrome p450-mediated Mono-oxygenase Activity that is Highly Induced by Phenobarbitone and β-Naphthoflavone. Journal of Pharmacy and Pharmacology 48:7, pages 729-733.
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D. Behera, A. Damre, A. Varghese & V. Addepalli. (2008) In Vitro Evaluation of Hepatic and Extra-hepatic Metabolism of Coumarins Using Rat Subcellular Fractions: Correlation of In Vitro Clearance with In Vivo Data. Drug Metabolism and Drug Interactions 23:3-4.
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Mukul Das, Shipra Rastogi & Subhash K. Khanna. (2004) Mechanism to study 1:1 stoichiometry of NADPH and alkoxyphenoxazones metabolism spectrophotometrically in subcellular biological preparations. Biochimica et Biophysica Acta (BBA) - General Subjects 1675:1-3, pages 1-11.
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Alison H. Hammond, Michael J. Garle & Jeffrey R. Fry. (1999) The Nature of Halogen Substitution Determines the Mode of Cytotoxicity of Halopropanols. Toxicology and Applied Pharmacology 155:3, pages 287-291.
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Dennis C. Morse, Adam P. Stein, Paul E. Thomas & Herbert E. Lowndes. (1998) Distribution and Induction of Cytochrome P450 1A1 and 1A2 in Rat Brain. Toxicology and Applied Pharmacology 152:1, pages 232-239.
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Thomas N. Thompson. 1997. 205 229 .
Frank Thies & L.Horst Grimme. (1994) In vivo O-dealkylation of resorufin and coumarin ethers by the green alga Chlorella fusca analysed by a rapid and sensitive high-performance liquid chromatographic assay. Journal of Chromatography A 684:1, pages 168-173.
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Mary L. Haasch, Wendy K. Graf, Ellen M. Quardokus, Richard T. Mayer & John J. Lech. (1994) Use of 7-alkoxyphenoxazones, 7-alkoxycoumarins and 7-alkoxyquinolines as fluorescent substrates for rainbow trout hepatic microsomes after treatment with various inducers. Biochemical Pharmacology 47:5, pages 893-903.
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Alison H. Hammond & Jeffrey R. Fry. (1994) Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time. Toxicology Letters 70:3, pages 337-342.
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Alison H. Hammond & Jeffrey R. Fry. (1993) Maintenance of xenobiotic metabolism and toxicity in rat hepatocyte cultures after cell preservation at 4°. Biochemical Pharmacology 46:2, pages 333-335.
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