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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 3
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Original Article

Metabolism of coumarin by rat, gerbil and human liver microsomes

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Pages 357-367 | Received 03 Aug 1991, Accepted 20 Nov 1991, Published online: 27 Aug 2009

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Read on this site (7)

Douglas J. Fort, Enos L. Stover, Timothy Propst, Mendi A. Hull & John A. Bantle. (1998) Evaluation of the Developmental Toxicities of Coumarin, 4-Hydroxycoumarin, and 7-Hydroxycoumarin Using Fetax. Drug and Chemical Toxicology 21:1, pages 15-26.
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D. P. Bogan, B. Deasy, R. O'kennedy & M. R. Smyth. (1996) Interspecies differences in coumarin metabolism in liver microsomes examined by capillary electrophoresis. Xenobiotica 26:4, pages 437-445.
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John D. Hayes & David J. Pulford. (1995) The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part II. Critical Reviews in Biochemistry and Molecular Biology 30:6, pages 521-600.
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John D. Hayes & David J. Pulford. (1995) The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I. Critical Reviews in Biochemistry and Molecular Biology 30:6, pages 445-520.
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B. G. Lake, M. J. Sauer, F. Esclangon, J. A. Beamand, R. J. Price & D. G. Walters. (1995) Metabolism of coumarin by precision-cut calf liver slices and calf liver microsomes. Xenobiotica 25:2, pages 133-141.
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A. Steensma, J. A. Beamand, D. G. Walters, R. J. Price & B. G. Lake. (1994) Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, Cynomolgus monkey and human precision-cut liver slices. Xenobiotica 24:9, pages 893-907.
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M. L. P. S. Van Iersel, C. J. Henderson, D. G. Walters, R. J. Price, C. R. Wolf & B. G. Lake. (1994) Metabolism of [3-14C] coumarin by human liver microsomes. Xenobiotica 24:8, pages 795-803.
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Articles from other publishers (28)

Zili Xu, Huihui Wang, Haixia Liu, Hongli Chen & Biao Jiang. (2022) Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prodrugs of a NAMPT Inhibitor FK866. Molecules 28:1, pages 169.
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Takashi Yamada, Naruo Katsutani, Taeko Maruyama, Tomoko Kawamura, Hiroshi Yamazaki, Norie Murayama, Weida Tong, Yasushi Yamazoe & Akihiko Hirose. (2022) Combined Risk Assessment of Food-derived Coumarin with <i>in Silico</i> Approaches. Food Safety 10:3, pages 73-82.
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Maria T Baltazar, Sophie Cable, Paul L Carmichael, Richard Cubberley, Tom Cull, Mona Delagrange, Matthew P Dent, Sarah Hatherell, Jade Houghton, Predrag Kukic, Hequn Li, Mi-Young Lee, Sophie Malcomber, Alistair M Middleton, Thomas E Moxon, Alexis V Nathanail, Beate Nicol, Ruth Pendlington, Georgia Reynolds, Joe Reynolds, Andrew White & Carl Westmoreland. (2020) A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products. Toxicological Sciences 176:1, pages 236-252.
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ChingYi Jennifer Hsieh, Meng Sun, Gwendolyn Osborne, Karin Ricker, Feng C. Tsai, Kate Li, Rajpal Tomar, Jimmy Phuong, Rose Schmitz & Martha S. Sandy. (2019) Cancer Hazard Identification Integrating Human Variability: The Case of Coumarin. International Journal of Toxicology 38:6, pages 501-552.
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A.L. Oliveira, L.N.L. Pozza, D.N. Santos, E.S. Kamimura, E. Vicente & F.A. Cabral. (2013) Supercritical extraction of coumarin from guaco (Mikania laevigata and Mikania glomerata) for pharmaceutical applications. The Journal of Supercritical Fluids 83, pages 65-71.
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Feixiong Cheng. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Vessela D. Kancheva, Luciano Saso, Petya V. Boranova, Abdullah Khan, Manju K. Saroj, Mukesh K. Pandey, Shashwat Malhotra, Jordan Z. Nechev, Sunil K. Sharma, Ashok K. Prasad, Maya B. Georgieva, Carleta Joseph, Anthony L. DePass, Ramesh C. Rastogi & Virinder S. Parmar. (2010) Structure–activity relationship of dihydroxy-4-methylcoumarins as powerful antioxidants: Correlation between experimental & theoretical data and synergistic effect. Biochimie 92:9, pages 1089-1100.
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Anne S. Kienhuis, Heleen M. Wortelboer, Jean-Christophe Hoflack, Edwin J. Moonen, Jos C.S. Kleinjans, Ben van Ommen, Joost H. M. van Delft & Rob H. Stierum. (2006) Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach. Drug Metabolism and Disposition 34:12, pages 2083-2090.
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. (2004) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Coumarin. EFSA Journal 2:12, pages 104.
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Eimear M. Ward, Malcolm R. Smyth, Richard O'Kennedy & Craig E. Lunte. (2003) Application of capillary electrophoresis with pH-mediated sample stacking to analysis of coumarin metabolites in microsomal incubations. Journal of Pharmaceutical and Biomedical Analysis 32:4-5, pages 813-822.
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Stephanie L. Born, Douglas Caudill, Kristine L. Fliter & Michael P. Purdon. (2002) Identification of the Cytochromes P450 That Catalyze Coumarin 3,4-Epoxidation and 3-Hydroxylation. Drug Metabolism and Disposition 30:5, pages 483-487.
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D.E Goeger, A.W Hsie & K.E Anderson. (1999) Co-mutagenicity of Coumarin (1,2-benzopyrone) with Aflatoxin B1 and Human Liver S9 in Mammalian Cells. Food and Chemical Toxicology 37:6, pages 581-589.
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B.G Lake. (1999) Coumarin Metabolism, Toxicity and Carcinogenicity: Relevance for Human Risk Assessment. Food and Chemical Toxicology 37:4, pages 423-453.
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Krishna R Iyer & Michael W Sinz. (1999) Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations. Chemico-Biological Interactions 118:2, pages 151-169.
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D.F.V Lewis, M Dickins, B.G Lake, P.J Eddershaw, M.H Tarbit & P.S Goldfarb. (1999) Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity. Toxicology 133:1, pages 1-33.
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Albena T. Dinkova-Kostova, Chitrananda Abeygunawardana & Paul Talalay. (1998) Chemoprotective Properties of Phenylpropenoids, Bis(benzylidene)cycloalkanones, and Related Michael Reaction Acceptors:  Correlation of Potencies as Phase 2 Enzyme Inducers and Radical Scavengers. Journal of Medicinal Chemistry 41:26, pages 5287-5296.
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U.D. Kuhn, F.K. Splinter, M. Rost & D. Müller. (1998) Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin. Experimental and Toxicologic Pathology 50:4-6, pages 491-496.
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Evan D. Kharasch, Douglas C. Hankins, Pamela J. Baxter & Kenneth E. Thummel. (1998) Single-dose disulfiram does not inhibit CYP2A6 activity*. Clinical Pharmacology & Therapeutics 64:1, pages 39-45.
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K. Anderson, R. Wilkinson & M.H. Grant. (2018) Assessment of Liver Function in Primary Cultures of Hepatocytes Using Diethoxy (5,6) Chloromethylfluorescein and Confocal Laser Scanning Microscopy. The International Journal of Artificial Organs 21:6, pages 360-364.
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T.B. Adams, D.B. Greer, J. Doull, I.C. Munro, P. Newberne, P.S. Portoghese, R.L. Smith, B.M. Wagner, C.S. Weil, L.A. Woods & R.A. Ford. (1998) The FEMA GRAS Assessment of Lactones Used as Flavour Ingredients. Food and Chemical Toxicology 36:4, pages 249-278.
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Douglas E. Goeger, Karl E. Anderson & Abraham W. Hsie. (1998) Coumarin chemoprotection against aflatoxin B1-induced gene mutation in a mammalian cell system: A species difference in mutagen activation and protection with chick embryo and rat liver S9. Environmental and Molecular Mutagenesis 32:1, pages 64-74.
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D. Ratanasavanh, D. Lamiable, M. Biour, Y. Guédès, M. Gersberg, E. Leutenegger & C. Riché. (2009) Metabolism and toxicity of coumarin on cultured human, rat, mouse and rabbit hepatocytes. Fundamental & Clinical Pharmacology 10:6, pages 504-510.
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R.J. Price, A.B. Renwick, J.A. Beamand, F. Esclangon, P.T. Wield, D.G. Walters & B.G. Lake. (1995) Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. Food and Chemical Toxicology 33:3, pages 233-237.
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B.G. Lake, J.G. Evans, D.F.V. Lewis & R.J. Price. (1994) Studies on the acute effects of coumarin and some coumarin derivatives in the rat. Food and Chemical Toxicology 32:4, pages 357-363.
Crossref
B.G. Lake, J.G. Evans, D.F.V. Lewis & R.J. Price. (1994) Comparison of the hepatic effects of coumarin, 3,4-Dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat. Food and Chemical Toxicology 32:8, pages 743-751.
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B.G. Lake & J.G. Evans. (1993) Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat. Food and Chemical Toxicology 31:12, pages 963-970.
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J. R. Fry. (1993) Development in in vitro toxicology. Comparative Haematology International 3:1, pages 4-7.
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Julia H. Fentem & Jeffrey R. Fry. (1993) Species differences in the metabolism and hepatotoxicity of coumarin. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 104:1, pages 1-8.
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