Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 4
44
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Metabolism of albendazole and albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle

, , &
Pages 419-426 | Received 03 Jun 1991, Accepted 03 Oct 1991, Published online: 27 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Karen Larsen, Adrián Lifschitz, Rocío Fernández San Juan & Guillermo Virkel. (2022) Metabolic stability of glyphosate and its environmental metabolite (aminomethylphosphonic acid) in the ruminal content of cattle. Food Additives & Contaminants: Part A 39:4, pages 740-751.
Read now
Zenaís Busatto, Welliton Gonçalves de França, José Eurico Possebon Cyrino & Jonas Augusto Rizzato Paschoal. (2018) Assessment of elimination profile of albendazole residues in fish. Food Additives & Contaminants: Part A 35:1, pages 77-85.
Read now
Zenaís Busatto, Agnaldo Fernando Baldo da Silva, Osvaldo de Freitas & Jonas Augusto Rizzato Paschoal. (2017) LC-MS/MS methods for albendazole analysis in feed and its metabolite residues in fish fillet and a leaching study in feed after an alternative procedure for drug incorporation. Food Additives & Contaminants: Part A 34:4, pages 509-519.
Read now
S. F. Sánchez, L. I. Alvarez & C. E. Lanusse. (1996) Nutritional condition affects the disposition kinetics of albendazole in cattle. Xenobiotica 26:3, pages 307-319.
Read now
C. Villaverde, A. I. Alvarez, P. Redondo, J. Voces, J. L. Del Estal & J. G. Prieto. (1995) Small intestinal sulphoxidation of Albendazole. Xenobiotica 25:5, pages 433-441.
Read now
Carlos E. Lanusse & Roger K. Prichard. (1993) Clinical Pharmacokinetics and Metabolism of Benzimidazole Anthelmintics in Ruminants. Drug Metabolism Reviews 25:3, pages 235-279.
Read now

Articles from other publishers (42)

Dauana Mesquita-Sousa, Nagilla R.C.L. Campos, Juliana R.F. Pereira, Matheus N. Gomes, Carolina R. Silva, Jose A.A. Cutrim-Júnior, Danilo R.B. Brito, Romildo M. Sampaio, Neil D. Sargison, Adrian Lifschitz & Livio M. Costa-Junior. (2023) Evaluation of a combination of Citrus aurantium var. Dulcis essential oil and albendazole for the treatment of sheep gastrointestinal nematodes. Veterinary Parasitology 318, pages 109929.
Crossref
Mian Zi Tee, Yi Xian Er, Alice V. Easton, Nan Jiun Yap, Ii Li Lee, Joseph Devlin, Ze Chen, Kee Seong Ng, Poorani Subramanian, Angelina Angelova, Oyebola Oyesola, Shushan Sargsian, Romano Ngui, Daniel P. Beiting, Christopher Chiong Meng Boey, Kek Heng Chua, Ken Cadwell, Yvonne Ai Lian Lim, P’ng Loke & Soo Ching Lee. (2022) Gut microbiome of helminth-infected indigenous Malaysians is context dependent. Microbiome 10:1.
Crossref
María Victoria Miró, Livio Martins Costa-Júnior, Luis Ignacio Alvarez, Carlos Lanusse, Guillermo Virkel & Adrián Lifschitz. (2022) Pharmacological characterization of geraniol in sheep and its potential use in the control of gastrointestinal nematodes. Veterinary and Animal Science 18, pages 100269.
Crossref
Cengiz Gokbulut, Veli Y. Cirak, Suleyman Aypak, Hamdi Avci, Selim Sekkin, Hande S. Yalinkilinc, Buket Boga & Erol Ayaz. (2021) In vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats . Journal of Veterinary Pharmacology and Therapeutics 44:5, pages 799-807.
Crossref
María Victoria Miró, Carolina Rocha e Silva, Paula Viviani, Sonia Luque, Mercedes Lloberas, Livio Martins Costa-Júnior, Carlos Lanusse, Guillermo Virkel & Adrián Lifschitz. (2020) Combination of bioactive phytochemicals and synthetic anthelmintics: In vivo and in vitro assessment of the albendazole-thymol association. Veterinary Parasitology 281, pages 109121.
Crossref
M. Ballent, G. Virkel, L. Maté, P. Viviani, C. Lanusse & A. Lifschitz. (2016) Hepatic biotransformation pathways and ruminal metabolic stability of the novel anthelmintic monepantel in sheep and cattle. Journal of Veterinary Pharmacology and Therapeutics 39:5, pages 488-496.
Crossref
D. YU, E. R. EVANS, N. HASBROUCK, R. REIMSCHUESSEL & B. SHAIKH. (2011) Residue depletion of albendazole and its metabolites in aquacultured yellow perch ( Perca flavescens ) . Journal of Veterinary Pharmacology and Therapeutics 35:6, pages 560-562.
Crossref
V. Křížová-Forstová, J. Lamka, V. Cvilink, V. Hanušová & L. Skálová. (2011) Factors affecting pharmacokinetics of benzimidazole anthelmintics in food-producing animals: The consequences and potential risks. Research in Veterinary Science 91:3, pages 333-341.
Crossref
Harriet Namwanje, Narcis B. Kabatereine & Annette Olsen. (2011) Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene 105:10, pages 586-590.
Crossref
Daniel B. Carrão, Keyller B. Borges, Thiago Barth, Mônica T. Pupo, Pierina S. Bonato & Anderson R. Moraes de Oliveira. (2011) Capillary electrophoresis and hollow fiber liquid-phase microextraction for the enantioselective determination of albendazole sulfoxide after biotransformation of albendazole by an endophytic fungus. ELECTROPHORESIS 32:19, pages 2746-2756.
Crossref
Moamen S. Refat, Gehad G. Mohamed & Ahmed Fathi. (2011) Spectrophotometric Determination of Albendazole Drug in Tablets: Spectroscopic Characterization of the Charge‐transfer Solid Complexes. Chinese Journal of Chemistry 29:2, pages 324-332.
Crossref
Bettencourt P.S. Capece, Guillermo L. Virkel & Carlos E. Lanusse. (2009) Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications. The Veterinary Journal 181:3, pages 241-250.
Crossref
Zimei Wu, Ian G. Tucker, Majid Razzak & Natalie J. Medlicott. (2009) Stability of ricobendazole in aqueous solutions. Journal of Pharmaceutical and Biomedical Analysis 49:5, pages 1282-1286.
Crossref
C. Gokbulut, V.Y. Cirak, B. Senlik, F. Yildirim & Q.A. McKellar. (2009) Pharmacological assessment of netobimin as a potential anthelmintic for use in horses: Plasma disposition, faecal excretion and efficacy. Research in Veterinary Science 86:3, pages 514-520.
Crossref
Laura Maté, Guillermo Virkel, Adrián Lifschitz, Mariana Ballent & Carlos Lanusse. (2008) Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep. Biochemical Pharmacology 76:6, pages 773-783.
Crossref
Cengiz Gokbulut, Umit Karademir, Murat Boyacioglu & Ferda Akar. (2007) The effect of diet type on the plasma disposition of triclabendazole in goats. Research in Veterinary Science 82:3, pages 388-391.
Crossref
Martin Danaher, Hendrik De Ruyck, Steven R.H. Crooks, Geraldine Dowling & Michael O’Keeffe. (2007) Review of methodology for the determination of benzimidazole residues in biological matrices. Journal of Chromatography B 845:1, pages 1-37.
Crossref
C. Gokbulut, V. Y. Cirak & B. Senlik. (2006) Plasma Disposition and Faecal Excretion of Netobimin Metabolites and Enantiospecific Disposition of Albendazole Sulphoxide Produced in Ewes. Veterinary Research Communications 30:7, pages 791-805.
Crossref
G. VIRKEL, A. LIFSCHITZ, J. SALLOVITZ, A. PIS & C. LANUSSE. (2006) Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep. Journal of Veterinary Pharmacology and Therapeutics 29:3, pages 213-223.
Crossref
A. LIFSCHITZ, G. VIRKEL, M. BALLENT, J. SALLOVITZ, A. PIS & C. LANUSSE. (2005) Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents. Journal of Veterinary Pharmacology and Therapeutics 28:5, pages 411-418.
Crossref
E. A. Formentini, N. Mestorino & J. O. Errecalde. (2005) Pharmacokinetics of Ricobendazole After its Intravenous, Intraruminal and Subcutaneous Administration in Sheep. Veterinary Research Communications 29:7, pages 595-608.
Crossref
J. Velík, B. Szotáková, V. Baliharová, J. Lamka, M. Šavlík, V. Wsól, E. Šnejdrová & L. Skálová. (2005) Albendazole repeated administration induces cytochromes P4501A and accelerates albendazole deactivation in mouflon (Ovis musimon). Research in Veterinary Science 78:3, pages 255-263.
Crossref
L. Moreno, F. Imperiale, L. Mottier, L. Alvarez & C. Lanusse. (2005) Comparison of milk residue profiles after oral and subcutaneous administration of benzimidazole anthelmintics to dairy cows. Analytica Chimica Acta 536:1-2, pages 91-99.
Crossref
G. Virkel, A. Lifschitz, J. Sallovitz, G. Inza & C. Lanusse. (2004) Effect of the ionophore antibiotic monensin on the ruminal biotransformation of benzimidazole anthelmintics. The Veterinary Journal 167:3, pages 265-271.
Crossref
B. Shaikh, N. Rummel, C. Gieseker, S. Serfling & R. Reimschuessel. (2003) Metabolism and residue depletion of albendazole and its metabolites in rainbow trout, tilapia and Atlantic salmon after oral administration. Journal of Veterinary Pharmacology and Therapeutics 26:6, pages 421-427.
Crossref
M.L. Mottier, L.I. Alvarez, M.A. Pis & C.E. Lanusse. (2003) Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol–water partition coefficients. Experimental Parasitology 103:1-2, pages 1-7.
Crossref
G. VIRKEL, A. LIFSCHITZ, A. PIS & C. LANUSSE. (2002) In vitro ruminal biotransformation of benzimidazole sulphoxide anthelmintics: enantioselective sulphoreduction in sheep and cattle . Journal of Veterinary Pharmacology and Therapeutics 25:1, pages 15-23.
Crossref
E. A. Formentini, O. N. Mestorino, E. L. Mariño & J. O. Errecalde. (2001) Pharmacokinetics of ricobendazole in calves. Journal of Veterinary Pharmacology and Therapeutics 24:3, pages 199-202.
Crossref
C. Cristofol, G. Virkel, L. Alvarez, S. Sanchez, M. Arboix & C. Lanusse. (2001) Albendazole sulphoxide enantiomeric ratios in plasma and target tissues after intravenous administration of ricobendazole to cattle. Journal of Veterinary Pharmacology and Therapeutics 24:2, pages 117-124.
Crossref
G. MERINO, A.I. ALVAREZ, P.A. REDONDO, J.L. GARCIA, O.M. LARRODÉ & J.G. PRIETO. (1999) Bioavailability of albendazole sulphoxide after netobimin administration in sheep: effects of fenbendazole coadministration.. Research in Veterinary Science 66:3, pages 281-283.
Crossref
Alvarez, Sánchez & Lanusse. (2002) In vivo and ex vivo uptake of albendazole and its sulphoxide metabolite by cestode parasites: relationship with their kinetic behaviour in sheep . Journal of Veterinary Pharmacology and Therapeutics 22:2, pages 77-86.
Crossref
G. Virkel, A. Lifschitz, A. Pis & C. Lanusse. (1999) Influence of diet on the pattern of gastrointestinal biotransformation of netobimin and albendazole sulphoxide in sheep. European Journal of Drug Metabolism and Pharmacokinetics 24:1, pages 31-37.
Crossref
C.E. Lanusse, G.L. Virkel, S.F. Sanchez, L.I. Alvarez, A.L. Lifschitz, F. Imperiale & A. Monfrinotti. (1998) Ricobendazole kinetics and availability following subcutaneous administration of a novel injectable formulation to calves. Research in Veterinary Science 65:1, pages 5-10.
Crossref
Mads Bjelke Petersen, Christian Friis & Henrik Bjørn. (1997) A new in vitro assay of benzimidazole activity against adult Oesophagostomum dentatum. International Journal for Parasitology 27:11, pages 1333-1339.
Crossref
Maria Luz Lopez-Garcia, Susana Torrado-Duran, Juan Torrado-Duran, Antonio Ramon Martínez-Fernández & Francisco Bolás-Fernández. (1997) Albendazole versus ricobendazole (albendazole-sulphoxide) against enteral and parenteral stages of Trichinella spiralis in mice. International Journal for Parasitology 27:7, pages 781-785.
Crossref
C Cristòfol, C Franquelo, M Navarro, A Carretero, J Ruberte & M Arboix. (1997) Comparative pharmacokinetics of netobimin metabolites in pregnant ewes. Research in Veterinary Science 62:2, pages 117-120.
Crossref
Marco De Liguoro, Francesca Longo, Gianfranco Brambilla, Annalucia Cinquina, Adriana Bocca & Antonia Lucisano. (2009) Distribution of the anthelmintic drug albendazole and its major metabolites in ovine milk and milk products after a single oral dose. Journal of Dairy Research 63:4, pages 533-542.
Crossref
Bakela Nare, George Lubega, Roger K. Prichard & Elias Georges. (1996) p-Azidosalicyl-5-amino-6-phenoxybenzimidazole Photolabels the N-terminal 63 103 Amino Acids of Haemonchus contortus -Tubulin 1. Journal of Biological Chemistry 271:15, pages 8575-8581.
Crossref
C. CRISTOFOL, J. E. VALLADARES, C. FRANQUELO, G. MARTI & M. ARBOIX. (2008) Pharmacokinetics of indomethacin in cattle. Journal of Veterinary Pharmacology and Therapeutics 19:1, pages 72-74.
Crossref
C.E. LANUSSE, L.H. GASCON & R.K. PRICHARD. (2008) Comparative plasma disposition kinetics of albendazole, fenbendazole, oxfendazole and their metabolites in adult sheep. Journal of Veterinary Pharmacology and Therapeutics 18:3, pages 196-203.
Crossref
Carlos E. Lanusse & Roger K. Prichard. (1993) Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Veterinary Parasitology 49:2-4, pages 123-158.
Crossref
C. E. LANUSSE, L. H. GASCON & R. K. PRICHARD. (2008) Gastrointestinal distribution of albendazole metabolites following netobimin administration to cattle: relationship with plasma disposition kinetics. Journal of Veterinary Pharmacology and Therapeutics 16:1, pages 38-47.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.