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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 8
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Research Article

A potentially new metabolic pathway: ethyl esterification of acitretin

R. C. Chou Pharma Division, Preclinical and Clinical Research, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland
,
R. Wyss Pharma Division, Preclinical and Clinical Research, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland
,
C. A. Huselton Pharma Division, Preclinical and Clinical Research, Nutley USA
&
U.-W. Wiegand Pharma Division, Preclinical and Clinical Research, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland
Pages 993-1002 | Received 03 Mar 1992, Accepted 20 May 1992, Published online: 22 Sep 2008

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M. Lakeram, A. J. Paine, D. J. Lockley, D. J. Sanders, R. Pendlington & B. Forbes. (2006) Transesterification of -hydroxybenzoate esters (parabens) by human intestinal (Caco-2) cells. Xenobiotica 36:9, pages 739-749.
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Articles from other publishers (17)

Sunil Dogra & Savita Yadav. (2014) Acitretin in psoriasis: an evolving scenario. International Journal of Dermatology 53:5, pages 525-538.
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Chieri Fujino, Yoko Watanabe, Naoto Uramaru & Shigeyuki Kitamura. (2014) Transesterification of a series of 12 parabens by liver and small-intestinal microsomes of rats and humans. Food and Chemical Toxicology 64, pages 361-368.
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Herbert Hönigsmann, Adrian Tanew & Warwick L. Morison. 2009. Dermatological Phototherapy and Photodiagnostic Methods. Dermatological Phototherapy and Photodiagnostic Methods 79 101 .
Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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Olivier Sorg, S Kuenzli & J. H. Saurat. 2007. Retinoids and Carotenoids in Dermatology. Retinoids and Carotenoids in Dermatology 225 248 .
Stacy L. McClure, Jayme Valentine & Kenneth B. Gordon. (2002) Comparative Tolerability of Systemic Treatments for Plaque-Type Psoriasis. Drug Safety 25:13, pages 913-927.
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Kathleen M Knights, Rodolfo Gasser & Wolfgang Klemisch. (2000) In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. Biochemical Pharmacology 60:4, pages 507-516.
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H.Irving Katz, Jill Waalen & Eileen Enny Leach. (1999) Acitretin in psoriasis: An overview of adverse effects. Journal of the American Academy of Dermatology 41:3, pages S7-S12.
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Ulf-W. Wiegand & Ruby C. Chou. (1998) Pharmacokinetics of acitretin and etretinate. Journal of the American Academy of Dermatology 39:2, pages S25-S33.
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Steven R. Feldman. (1998) Psoriasis treatment. Current Problems in Dermatology 10:1, pages 1-40.
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Ronald Wyss & Franz Bucheli. (1997) Determination of endogenous levels of 13-cis-retinoic acid (isotretinoin), all-trans-retinoic acid (tretinoin) and their 4-oxo metabolites in human and animal plasma by high-performance liquid chromatography with automated column switching and ultraviolet detection. Journal of Chromatography B: Biomedical Sciences and Applications 700:1-2, pages 31-47.
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Ronald Marks. (1997) Clinical safety of tazarotene in the treatment of plaque psoriasis. Journal of the American Academy of Dermatology 37:2, pages S25-S32.
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A.G. Rauws, E.J. De Waal & J.W. Van Der Laan. 1997. Advances in Drug Research Volume 30. Advances in Drug Research Volume 30 15 72 .
H.P.M. GOLLNICK. (1996) Oral retinoids-efficacy and toxicity in psoriasis. British Journal of Dermatology 135, pages 6-17.
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A.H. Schmitt-Hoffmann, S. Dittrich, E. Saulnier, P. Schenk & R.C. Chou. (1995) Mechanistic studies on the ethyl-esterification of acitretin by human liver preparations in vitro. Life Sciences 57:26, pages PL407-PL412.
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Ronald Wyss. (1995) Chromatographic and electrophoretic analysis of biomedically important retinoids. Journal of Chromatography B: Biomedical Sciences and Applications 671:1-2, pages 381-425.
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Alan J Cooper. (1995) Dermatology. Medical Journal of Australia 163:1, pages 43-45.
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