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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 9-10
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Research Article

Metabolic activation of 1-nitropyrene to a mammalian cell mutagen and a carcinogen

F. A. Beland National Center for Toxicological Research, Jefferson, AR, 72079, USA; University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA
,
B. A. Smith National Center for Toxicological Research, Jefferson, AR, 72079, USA
,
J. R. Thornton-Manning National Center for Toxicological Research, Jefferson, AR, 72079, USA
&
R. H. Heflich National Center for Toxicological Research, Jefferson, AR, 72079, USA
Pages 1121-1133 | Received 20 Dec 1990, Accepted 17 Apr 1992, Published online: 22 Sep 2008

Citations (9)

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PeterP. Fu & Diogenes Herreno‐Saenz. (1999) Nitro‐polycyclic aromatic hydrocarbons: A class of genotoxic environmental pollutants. Journal of Environmental Science and Health, Part C 17:1, pages 1-43.
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Articles from other publishers (8)

Guosheng Chen, John Gingerich, Lynda Soper, George R. Douglas & Paul A. White. (2008) Tissue‐specific metabolic activation and mutagenicity of 3‐nitrobenzanthrone in Muta™Mouse. Environmental and Molecular Mutagenesis 49:8, pages 602-613.
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Byung-Wook Kim, Byung-Chun Kim, Jin-Soon Cha, Gerd P. Pfeifer & Chong-Soon Lee. (2008) Mutation spectra induced by 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide in the supF gene of human XP-A fibroblasts. BMB Reports 41:8, pages 604-608.
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Naoya Hatanaka, Hiroshi Yamazaki, Yoshimitsu Oda, F.Peter Guengerich, Miki Nakajima & Tsuyoshi Yokoi. (2001) Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 497:1-2, pages 223-233.
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Carys L Mitchelmore, Claudia Birmelin, J Kevin Chipman & David R Livingstone. (1998) Evidence for cytochrome P-450 catalysis and free radical involvement in the production of DNA strand breaks by benzo[a]pyrene and nitroaromatics in mussel (Mytilus edulis L.) digestive gland cells. Aquatic Toxicology 41:3, pages 193-212.
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C.L Mitchelmore & J.K Chipman. (1998) Detection of DNA strand breaks in brown trout (Salmo trutta) hepatocytes and blood cells using the single cell gel electrophoresis (comet) assay. Aquatic Toxicology 41:1-2, pages 161-182.
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Carys L. Mitchelmore, J.Kevin Chipman, Paz Garcia-Martinez, Philippe Lemaire, Laurence D. Peters & David R. Livingstone. (1996) Normal status of hepatic 7-ethoxyresorufin O-deethylase (EROD) activity, antioxidant enzymes and DNA oxidation in turbot (Scophthalmus maximus) and other flatfish species following exposure to nitroaromatic compounds. Marine Environmental Research 42:1-4, pages 329-333.
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K Savela, M J Kohan, D Walsh, F P Perera, K Hemminki & J Lewtas. (1996) In vitro characterization of DNA adducts formed by foundry air particulate matter.. Environmental Health Perspectives 104:suppl 3, pages 687-690.
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Carrie R. Valentine & Robert H. Heflich. (2006) Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of chinese hamster ovary cells . Environmental and Molecular Mutagenesis 25:2, pages 85-96.
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