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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 9-10
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Research Article

The role of the flavin-containing monooxygenase (EC 1.14.13.8) in the metabolism and mode of action of agricultural chemicals

E. Hodgson Department of Toxicology, North Carolina State University, Box 7633, Raleigh, NC, 27695, USA
&
P. E. Levi Department of Toxicology, North Carolina State University, Box 7633, Raleigh, NC, 27695, USA
Pages 1175-1183 | Received 26 Oct 1990, Accepted 24 Apr 1992, Published online: 22 Sep 2008

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John R. Cashman. (1998) Stereoselectivity in S- and N-Oxygenation by the Mammalian Flavin-Containing and Cytochrome P-450 Monooxygenases. Drug Metabolism Reviews 30:4, pages 675-707.
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N. J. CHERRINGTON, YAN CAO, J. W. CHERRINGTON, R. L. ROSE & E. HODGSON*. (1998) Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5. Xenobiotica 28:7, pages 673-682.
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Articles from other publishers (29)

Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Chang-Hwei ChenChang-Hwei Chen. 2020. Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense. Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense 59 70 .
X. Tian, S. Zhao, Z. Guo, B. Hu, Q. Wei, Y. Tang & J. Su. (2018) Molecular characterization, expression pattern and metabolic activity of flavin-dependent monooxygenases in Spodoptera exigua . Insect Molecular Biology 27:5, pages 533-544.
Crossref
Mohamed B. Abou-Donia. 2015. Mammalian Toxicology. Mammalian Toxicology 101 129 .
Ernest Hodgson. 2012. Pesticide Biotransformation and Disposition. Pesticide Biotransformation and Disposition 73 116 .
Chang-Hwei ChenChang-Hwei Chen. 2012. Activation and Detoxification Enzymes. Activation and Detoxification Enzymes 137 144 .
J. Marchand, E. Evrard, B. Guinand, J. Cachot, L. Quiniou & J. Laroche. (2010) Genetic polymorphism and its potential relation to environmental stress in five populations of the European flounder Platichthys flesus, along the French Atlantic coast. Marine Environmental Research 70:2, pages 201-209.
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Ernest Hodgson. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 893 921 .
E. Hodgson & S.A. Meyer. 2010. Comprehensive Toxicology. Comprehensive Toxicology 475 500 .
J. Marchand, A. Tanguy, G. Charrier, L. Quiniou, E. Plee-Gauthier & J. Laroche. (2006) Molecular Identification and Expression of Differentially Regulated Genes of the European Flounder, Platichthys flesus, Submitted to Pesticide Exposure. Marine Biotechnology 8:3, pages 275-294.
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John R. CashmanJun Zhang. (2006) HUMAN FLAVIN-CONTAINING MONOOXYGENASES. Annual Review of Pharmacology and Toxicology 46:1, pages 65-100.
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Sharon K. Krueger & David E. Williams. (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics 106:3, pages 357-387.
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Tabitha R. Chigwada, Edward Chikwana & Reuben H. Simoyi. (2005) S-Oxygenation of Thiocarbamides I:  Oxidation of Phenylthiourea by Chlorite in Acidic Media. The Journal of Physical Chemistry A 109:6, pages 1081-1093.
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S Kenyon, P.L Carmichael, S Khalaque, S Panchal, R Waring, R Harris, R.L Smith & S.C Mitchell. (2004) The passage of trimethylamine across rat and human skin. Food and Chemical Toxicology 42:10, pages 1619-1628.
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Marilyn C Henderson, Sharon K Krueger, Lisbeth K Siddens, Jan F Stevens & David E Williams. (2004) S-Oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2. Biochemical Pharmacology 68:5, pages 959-967.
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Dieter Lang & Amit Kalgutkar. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 483 539 .
Hack Sun Choi, Jin Kwon Kim, Eun Hee Cho, Yong Chul Kim, Jae Il Kim & Si Wouk Kim. (2003) A novel flavin-containing monooxygenase from Methylophaga sp. strain SK1 and its indigo synthesis in Escherichia coli. Biochemical and Biophysical Research Communications 306:4, pages 930-936.
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Herbert N. Nigg & James B. Knaak. 2000. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology 29 111 .
Allan Rettie & Michael Fisher. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 131 151 .
John Cashman. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 477 505 .
Gurpreet S Ratra, Winston A Morgan, Jenny Mullervy, Christopher J Powell & Matthew C Wright. (1998) Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil. Toxicology 130:2-3, pages 79-93.
Crossref
J.Greg Falls, Doug-Young Ryu, Yan Cao, Patricia E. Levi & Ernest Hodgson. (1997) Regulation of Mouse Liver Flavin-Containing Monooxygenases 1 and 3 by Sex Steroids. Archives of Biochemistry and Biophysics 342:2, pages 212-223.
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E Hodgson & P E Levi. (1996) Pesticides: an important but underused model for the environmental health sciences.. Environmental Health Perspectives 104:suppl 1, pages 97-106.
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G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1996. Introduction to Drug Metabolism. Introduction to Drug Metabolism 157 179 .
G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1996. Introduction to Drug Metabolism. Introduction to Drug Metabolism 35 76 .
E. Hodgson, R.L. Rose, D.-Y. Ryu, G. Falls, B.L. Blake & P.E. Levi. (1995) Pesticide-metabolizing enzymes. Toxicology Letters 82-83, pages 73-81.
Crossref
Ernest Hodgson, Randy L. Rose, Nancy H. Adams, Nora J. Deamer, Mary Beth Genter, Krishnappa Venkatesh & Patricia E. Levi. 1995. Molecular Aspects of Oxidative Drug Metabolizing Enzymes. Molecular Aspects of Oxidative Drug Metabolizing Enzymes 461 478 .
Ernest Hodgson, Bonnie L. Blake, Patricia E. Levi, Richard B. Mailman, Michael P. Lawton, Richard M. Philpot & Mary Beth Genter. 1995. Molecular Aspects of Oxidative Drug Metabolizing Enzymes. Molecular Aspects of Oxidative Drug Metabolizing Enzymes 225 235 .
Kashiyama Eiji, Yokoi Tsuyoshi, Itoh Kunio, Itoh Susumu, Odomi Masaaki & Kamataki Tetsuya. (1994) Stereoselective S-oxidation of flosequinan sulfide by rat hepatic flavin-containing monooxygenase 1A1 expressed in yeast. Biochemical Pharmacology 47:8, pages 1357-1363.
Crossref

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