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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 1
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Research Article

Reductive metabolism of the anticonvulsant agent zonisamide, a 1,2-benzisoxazole derivative

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Pages 1-11 | Received 05 Apr 1991, Published online: 22 Sep 2008

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J Lloyd Holder$suffix/text()$suffix/text() & Angus A Wilfong. (2011) Zonisamide in the treatment of epilepsy. Expert Opinion on Pharmacotherapy 12:16, pages 2573-2581.
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Hideto Miwa. (2007) Zonisamide for the treatment of Parkinson’s disease. Expert Review of Neurotherapeutics 7:9, pages 1077-1083.
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Angus A Wilfong & L James Willmore. (2006) Zonisamide – a review of experience and use in partial seizures. Neuropsychiatric Disease and Treatment 2:3, pages 269-280.
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A. E. Mutlib, S. Diamond, J. Shockcor, R. Way, G. Nemeth, L. Gan & D. D. Christ. (2000) Mass spectrometric and NMR characterization of metabolites of roxifiban, a potent and selective antagonist of the platelet glycoprotein IIb/IIIa receptor. Xenobiotica 30:11, pages 1091-1110.
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H. Nakasa, S. Ohmori & M. Kitada. (1996) Formation of 2-sulphamoylacetylphenol from zonisamide under aerobic conditions in rat liver microsomes. Xenobiotica 26:5, pages 495-501.
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Deepak Dalvie & Li Di. (2019) Aldehyde oxidase and its role as a drug metabolizing enzyme. Pharmacology & Therapeutics 201, pages 137-180.
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K. P. Rakesh, C. S. Shantharam, M. B. Sridhara, H. M. Manukumar & Hua-Li Qin. (2017) Benzisoxazole: a privileged scaffold for medicinal chemistry. MedChemComm 8:11, pages 2023-2039.
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Ian D. Wilson & Jeremy K. Nicholson. (2017) Gut microbiome interactions with drug metabolism, efficacy, and toxicity. Translational Research 179, pages 204-222.
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Ian D. Wilson & Jeremy K. Nicholson. 2015. Metabonomics and Gut Microbiota in Nutrition and Disease. Metabonomics and Gut Microbiota in Nutrition and Disease 323 341 .
Katarzyna M Bloch, Graeme J Sills, Munir Pirmohamed & Ana Alfirevic. (2014) Pharmacogenetics of antiepileptic drug-induced hypersensitivity. Pharmacogenomics 15:6, pages 857-868.
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M.L. Miller, S.A. Center, J.F. Randolph, M.L. Lepherd, M.A. Cautela & C.W. Dewey. (2011) Apparent Acute Idiosyncratic Hepatic Necrosis Associated with Zonisamide Administration in a Dog. Journal of Veterinary Internal Medicine 25:5, pages 1156-1160.
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Shigeyuki Kitamura, Kazumi Sugihara, Mie Kuwasako & Kiyoshi Tatsumi. (1997) The Role of Mammalian Intestinal Bacteria in the Reductive Metabolism of Zonisamide. Journal of Pharmacy and Pharmacology 49:3, pages 253-256.
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S. B. Benaka Prasad, K. Vinaya, C. S. Ananda Kumar, Sanjay Swarup & K. S. Rangappa. (2008) Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: A structure–activity relationship study. Investigational New Drugs 27:6, pages 534-542.
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Sabine Heberling, Ulrich Girreser, Stephanie Wolf & Bernd Clement. (2006) Oxygen-insensitive enzymatic reduction of oximes to imines. Biochemical Pharmacology 71:3, pages 354-365.
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Ilo E. Leppik. (2004) Zonisamide: chemistry, mechanism of action, and pharmacokinetics. Seizure 13, pages S5-S9.
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Monish Jain & Chul-Hoon Kwon. (2003) 1,2-Benzisoxazole Phosphorodiamidates as Novel Anticancer Prodrugs Requiring Bioreductive Activation. Journal of Medicinal Chemistry 46:25, pages 5428-5436.
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Richard A. Tschirret-Guth & Harold B. Wood. (2003) SUBSTITUENT EFFECT ON THE REDUCTIVE N- DEARYLATION OF 3-(INDOL-1-YL)-1,2-BENZISOXAZOLES BY RAT LIVER MICROSOMES . Drug Metabolism and Disposition 31:8, pages 999-1004.
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Deepak K. Dalvie, Amit S. Kalgutkar, S. Cyrus Khojasteh-Bakht, R. Scott Obach & John P. O'Donnell. (2002) Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings. Chemical Research in Toxicology 15:3, pages 269-299.
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F. Peter Guengerich. (2001) Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity. Chemical Research in Toxicology 14:6, pages 611-650.
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Shigeyuki KITAMURA, Keiko NAKATANI, Koji OHASHI, Kazumi SUGIHARA, Ryuji HOSOKAWA, Yasumasa AKAGAWA & Shigeru OHTA. (2001) Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver.. Biological and Pharmaceutical Bulletin 24:7, pages 856-859.
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David R Hawkins. (1999) Use and value of metabolism databases. Drug Discovery Today 4:10, pages 466-471.
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Ilo E. Leppik. (1999) Zonisamide. Epilepsia 40:s5, pages s23-s29.
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E. Tanaka. (1999) Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Journal of Clinical Pharmacy and Therapeutics 24:2, pages 87-92.
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I. E. Leppik. 1999. Antiepileptic Drugs. Antiepileptic Drugs 485 498 .
Gregory M. Kochak, John G. Page, Robert A. Buchanan, Richard Peters & Claire S. Padgett. (1998) Steady-State Pharmacokinetics of Zonisamide, an Antiepileptic Agent for Treatment of Refractory Complex Partial Seizures. The Journal of Clinical Pharmacology 38:2, pages 166-171.
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V.A. Eagling, J.L. Howe, M.J. Barry & D.J. Back. (1994) The metabolism of zidovudine by human liver microsomes in vitro: Formation of 3′-amino-3′-deoxythymidine. Biochemical Pharmacology 48:2, pages 267-276.
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