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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 1
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Research Article

Absorption, distribution and excretion of zenarestat, a new aldose reductase inhibitor, in rats and dogs

Y. Tanaka Product Development Laboratories, Fujisawa Pharmaceutical Co. Ltd, 2–1, Kashima, Yodogawaku, Osaka 532, Japan
,
M. Sekiguchi Product Development Laboratories, Fujisawa Pharmaceutical Co. Ltd, 2–1, Kashima, Yodogawaku, Osaka 532, Japan
,
T. Sawamoto Product Development Laboratories, Fujisawa Pharmaceutical Co. Ltd, 2–1, Kashima, Yodogawaku, Osaka 532, Japan
,
Y. Katami Tokai Research Laboratories, Daiichi Pure Chemicals Co. Ltd, Muramatsu, Tokai-mura, Naka-gun, Ibaraki-ken, 319-11, Japan
,
T. Ueda Tokai Research Laboratories, Daiichi Pure Chemicals Co. Ltd, Muramatsu, Tokai-mura, Naka-gun, Ibaraki-ken, 319-11, Japan
,
Y. Esumi Tokai Research Laboratories, Daiichi Pure Chemicals Co. Ltd, Muramatsu, Tokai-mura, Naka-gun, Ibaraki-ken, 319-11, Japan
&
K. Noda Product Development Laboratories, Fujisawa Pharmaceutical Co. Ltd, 2–1, Kashima, Yodogawaku, Osaka 532, Japan
 show all
Pages 57-64 | Received 05 Apr 1991, Published online: 22 Sep 2008

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M. Tsuda-Tsukimoto, Y. Ogasawara & T. Kume. (2005) Pharmacokinetics and metabolism of TR-14035, a novel antagonist of α4β1/α4β7 integrin mediated cell adhesion, in rat and dog. Xenobiotica 35:4, pages 373-389.
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Y. Tanaka, H. Shimojyo, T. Hata, M. Hashimoto & H. Noguchi. (1994) Toxicokinetics of zenarestat, an aldose reductase inhibitor in animals and man. Xenobiotica 24:5, pages 461-471.
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Articles from other publishers (4)

Mahavir Singh, Aniruddh Kapoor & Aruni Bhatnagar. (2021) Physiological and Pathological Roles of Aldose Reductase. Metabolites 11:10, pages 655.
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Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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Shoji Takakura, Hideaki Minoura, Yukinori Shimoshige, Kyoko Minoura, Ikuo Kawamura, Tomoichi Fujiwara, Takashi Saitoh, Fumio Shimojo, Jiro Seki & Toshio Goto. (2001) Enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, and its relevance in the use of zenarestat as a therapeutic agent against diabetic neuropathy. Drug Development Research 54:1, pages 27-34.
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Satoshi Horie, Hitoshi Nagai, Takashi Yuuki, Yuji Narita, Yoshio Tsuda, Tsunetaka Nakajima & Norifumi Nakamura. (1998) Effect of SG-210, a Novel Aldose Reductase Inhibitor, on Impaired Polyol Pathway in Rats Received Diabetic Manipulations. Journal of Diabetes and its Complications 12:3, pages 163-169.
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