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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 1
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Research Article

Propofol metabolism in man during the anhepatic and reperfusion phases of liver transplantation

P. A. Gray Department of Anaesthesia, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK
,
G. R. Park Department of Anaesthesia, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK
,
I. D. Cockshott Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
E. J. Douglas Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
B. Shuker Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
&
P. J. Simons Safety of Medicines Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Pages 105-114 | Received 10 Aug 1990, Accepted 31 Jul 1991, Published online: 22 Sep 2008

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Kathleen M. Knights & John O. Miners. (2010) Renal UDP-glucuronosyltransferases and the glucuronidation of xenobiotics and endogenous mediators. Drug Metabolism Reviews 42:1, pages 63-73.
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G. R. Park. (1993) Pharmacokinetics and pharmacodynamics in the critically ill patient. Xenobiotica 23:11, pages 1195-1230.
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Articles from other publishers (27)

A. Savoca, K. van Heusden, D. Manca, J.M. Ansermino & G.A. Dumont. (2020) The effect of cardiac output on the pharmacokinetics and pharmacodynamics of propofol during closed-loop induction of anesthesia. Computer Methods and Programs in Biomedicine 192, pages 105406.
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J.-P. Haberer. (2019) Propofol: metabolismo y farmacocinética. EMC - Anestesia-Reanimación 45:3, pages 1-16.
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J.-P. Haberer. (2019) Propofol: metabolismo e farmacocinetica. EMC - Anestesia-Rianimazione 24:3, pages 1-15.
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Ricardo Jorge Dinis-Oliveira. (2018) Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects. BioMed Research International 2018, pages 1-16.
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Kathleen M. Knights, Andrew Rowland & John O. Miners. (2013) Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 ( CYP ) and UDP ‐glucuronosyltransferase ( UGT ) . British Journal of Clinical Pharmacology 76:4, pages 587-602.
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Bill Vestergaard, Henrik Agersø & Jens Lykkesfeldt. (2013) Nephrectomized and Hepatectomized Animal Models as Tools in Preclinical Pharmacokinetics. Basic & Clinical Pharmacology & Toxicology 113:2, pages 75-86.
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Mohamed Abo El Hamd. (2013) The Clinical Pharmacology of Propofol:A Brief Review. Open Journal of Anesthesiology 03:08, pages 367-373.
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Derek J. Roberts, Babar Haroon & Richard I. Hall. (2012) Sedation for Critically Ill or Injured Adults in the Intensive Care Unit. Drugs 72:14, pages 1881-1916.
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J. C. Song, Y. M. Sun, M. Z. Zhang, L. Q. Yang, T. Z. Tao & W. F. Yu. (2011) The Etomidate Requirement Is Decreased in Patients with Obstructive Jaundice. Anesthesia & Analgesia 113:5, pages 1028-1032.
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J.G. Reves, Peter S.A. Glass, David A. Lubarsky, Matthew D. McEvoy & Ricardo Martinez-Ruiz. 2010. Miller's Anesthesia. Miller's Anesthesia 719 768 .
Suraphong Lorsomradee, Stefanie Cromheecke, Sratwadee Lorsomradee & Stefan G. De Hert. (2006) Effects of Sevoflurane on Biomechanical Markers of Hepatic and Renal Dysfunction After Coronary Artery Surgery. Journal of Cardiothoracic and Vascular Anesthesia 20:5, pages 684-690.
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David G Levitt & Thomas W Schnider. (2005) Human physiologically based pharmacokinetic model for propofol. BMC Anesthesiology 5:1.
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T. Murayama, Y. Sato, T. Wainai, A. Enomoto, N. Seo, H. Yoshino & E. Kobayashi. (2005) Effect of Continuous Infusion of Propofol on Its Concentration in Blood With and Without the Liver in Pigs. Transplantation Proceedings 37:10, pages 4567-4570.
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D. Takizawa, E. Sato, H. Hiraoka, A. Tomioka, K. Yamamoto, R. Horiuchi & F. Goto. (2005) Changes in apparent systemic clearance of propofol during transplantation of living related donor liver. British Journal of Anaesthesia 95:5, pages 643-647.
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Haruhiko Hiraoka, Koujirou Yamamoto, Soutarou Miyoshi, Toshihiro Morita, Katsunori Nakamura, Yuuji Kadoi, Fumio Kunimoto & Ryuya Horiuchi. (2005) Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain. British Journal of Clinical Pharmacology 60:2, pages 176-182.
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J. Wu, S. M. Zhu, H. L. He, X. C. Weng, S. Q. Huang & Y. Z. Chen. (2005) Plasma propofol concentrations during orthotopic liver transplantation. Acta Anaesthesiologica Scandinavica 49:6, pages 804-810.
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Takashi Mizuma & Shoji Awazu. (2004) Dietary polyphenols (−)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption. Journal of Pharmaceutical Sciences 93:9, pages 2407-2410.
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A. A. Van Den Berg, P. Neuvonen & M. Ezz. (2008) Neuroexcitatory symptoms after propofol: a phenol related neurotoxic effect?. Acta Anaesthesiologica Scandinavica 45:8, pages 1051-1051.
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Yutaka Oda, Naoya Hamaoka, Toyoko Hiroi, Susumu Imaoka, Ichiro Hase, Kazuo Tanaka, Yoshihiko Funae, Takashi Ishizaki & Akira Asada. (2008) Involvement of human liver cytochrome P4502B6in the metabolism of propofol. British Journal of Clinical Pharmacology 51:3, pages 281-285.
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Christy McCowan & Paul Marik. (2000) Refractory delirium tremens treated with propofol: A case series. Critical Care Medicine 28:6, pages 1781-1784.
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N. Van Brandt, P. Hantson, Y. Horsmans, P. Mahieu & R. K. Verbeeck. (1998) Effect of enteral versus parenteral feeding on hepatic blood flow and steady state propofol pharmacokinetics in ICU patients. Intensive Care Medicine 24:8, pages 795-800.
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Gerard J. Mulder. (1998) 5 Glucuronidation and anaesthesia. Baillière's Clinical Anaesthesiology 12:2, pages 229-245.
Crossref
L. Godsiff & G.R. Park. 1997. Molecular and Cellular Pharmacology. Molecular and Cellular Pharmacology 233 251 .
Chantal Le Guellec, Bruno Lacarelle, Pierre-Henri Villard, Huguette Point, Jacques Catalin & Alain Durand. (1995) Glucuronidation of Propofol in Microsomal Fractions from Various Tissues and Species Including Humans. Anesthesia & Analgesia 81:4, pages 855-861.
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Chantal Le Guellec, Bruno Lacarelle, Pierre-Henri Villard, Huguette Point, Jacques Catalin & Alain Durand. (1995) Glucuronidation of Propofol in Microsomal Fractions from Various Tissues and Species Including Humans. Anesthesia & Analgesia 81:4, pages 855-861.
Crossref
Carol A. Moote. (1994) ANESTHESIA FOR RENAL TRANSPLANTATION. Anesthesiology Clinics of North America 12:4, pages 691-715.
Crossref
G. R. Park, B. I. Podkowik & F. Hoffmann‐La. (2007) Plasma concentrations of flumazenil during liver transplantation. Anaesthesia 47:10, pages 887-889.
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