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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 7
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Research Article

Comparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes

K. Lavrijsen Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
J. Van Houdt Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
D. Van Dyck Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
J. Hendrickx Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
M. Bockx Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
R. Hurkmans Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
W. Meuldermans Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
L. Le Jeune Department of Analytical Research, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
,
W. Lauwers Department of Analytical Research, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
&
J. Heykants Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, B-2340, Beerse, Belgium
 show all
Pages 815-836 | Received 11 May 1991, Accepted 23 Oct 1991, Published online: 22 Sep 2008

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Qinghua Wu, Lingli Huang, Zhaoying Liu, Min Yao, Yulian Wang, Menghong Dai & Zonghui Yuan. (2011) A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp. Xenobiotica 41:10, pages 863-873.
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Carol A. Marchant, Katharine A. Briggs & Anthony Long. (2008) In Silico Tools for Sharing Data and Knowledge on Toxicity and Metabolism: Derek for Windows, Meteor, and Vitic. Toxicology Mechanisms and Methods 18:2-3, pages 177-187.
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M. C. Dumasia. (2002) Biotransformation of cyclizine in greyhounds. 2: N 1 -dealkylation and identification of some neutral and phenolic metabolites in canine urine by gas chromatography-mass spectrometry. Xenobiotica 32:9, pages 809-821.
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D. M. CROSS & M. K. BAYLISS. (2000) A COMMENTARY ON THE USE OF HEPATOCYTES IN DRUG METABOLISM STUDIES DURING DRUG DISCOVERY AND DEVELOPMENT*. Drug Metabolism Reviews 32:2, pages 219-240.
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Ming-Ren Fuh, Yee-Fu Chan, Wynn W. H. Pan & I.-Ping Huang. (1999) DETERMINATION OF FLUNARIZINE IN RAT'S BRAIN BY LIQUID CHROMATOGRAPHY WITH UV/VISIBLE DETECTION. Journal of Liquid Chromatography & Related Technologies 22:16, pages 2525-2533.
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NICOLA J. SWALES & DIETMAR UTESCH. (1998) Metabolic activity of fresh and cryopreserved dog hepatocyte suspensions. Xenobiotica 28:10, pages 937-948.
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F. Salmon & W. Kohl. (1996) Use of fresh and cryopreserved hepatocytes to study the metabolism of pesticides in food-producing animals and rats. Xenobiotica 26:8, pages 803-811.
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A. Bader, K. Zech, O. Crome, U. Christians, B. Ringe, R. Pichlmayr & K-Fr. Sewing. (1994) Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica 24:7, pages 623-633.
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K. Lee, Y. Vandenberghe, M. Herin, R. Cavalier, D. Beck, A. Li, N. Verbeke, M. Lesne & J. Roba. (1994) Comparative metabolism of SC-42867 and SC-51089, two PGE2 antagonists, in rat and human hepatocyte cultures. Xenobiotica 24:1, pages 25-36.
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B. Vallès, Ph. Coassolo, G. de Sousa, C. Aubert & R. Rahmani. (1993) In vitro hepatic biotransformation of moclobemide (Ro 11-1163) in man and rat. Xenobiotica 23:10, pages 1101-1111.
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Y. Nishibe & M. Hirata. (1993) Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes. Xenobiotica 23:6, pages 681-692.
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J. A. Bell & M. H. Tarbit. (1992) Twenty years on: a review of the current practice of drug metabolism and pharmacokinetic studies in the pharmaceutical industry. Xenobiotica 22:7, pages 735-742.
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Martin K. Bayliss & David M. Cross. 2000. The Hepatocyte Review. The Hepatocyte Review 365 389 .
Ming-Ren Fuh & Chi-Jen Hsieh. (1999) Determination of flunarizine in rat brain by liquid chromatography–electrospray mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 736:1-2, pages 167-173.
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Sean Ekins, Jukka Maenpää & Steven Wrighton. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 363 399 .
E. Damatte, M. J. Galmier, C. Lartigue-Mattei, J. F. Pognat, N. Busch & J. L. Chabard. (1996) Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity. European Journal of Drug Metabolism and Pharmacokinetics 21:4, pages 315-325.
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G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1994. Introduction to Drug Metabolism. Introduction to Drug Metabolism 180 216 .
G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1994. Introduction to Drug Metabolism. Introduction to Drug Metabolism 133 156 .
Satoru Kariya, Sadao Isozaki, Yasuhiro Masubuchi, Tokuji Suzuki & Shizuo Narimatsu. (1995) Possible pharmacokinetic and pharmacodynamic factors affecting parkinsonism inducement by cinnarizine and flunarizine. Biochemical Pharmacology 50:10, pages 1645-1650.
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Shuet-Hing Lee Chiu. (1993) The use of in vitro metabolism studies in the understanding of new drugs. Journal of Pharmacological and Toxicological Methods 29:2, pages 77-83.
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