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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 7
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Research Article

Value of early pharmacodynamic and pharmacokinetic investigations with anticancer drugs: data from phase I tolerance studies on a new vinca alkaloid derivative

R. M. J. Ings Servier Research and Development Ltd, Fulmer, Bucks, SL3 6HH, UK
,
E. Lelièvre Laboratoire Servier, rue Eugène, Vignat, 4500, Orléans, France
,
C. Ardiet Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, Cédex 08, France
,
M. Clavel Centre Léon Bérard, 28 rue Laënnec, 69373, Lyon, Cédex 08, France
,
S. Leyvraz CHUV de Lausanne, 10011, Lausanne, Switzerland
,
D. Minaidis CHUV de Lausanne, 10011, Lausanne, Switzerland
,
F. Lokiec Centre René Huguenin, 5 rue Gaston Latouche, 9211, St Cloud, Cédex, France
,
F. Turpin Centre René Huguenin, 5 rue Gaston Latouche, 9211, St Cloud, Cédex, France
,
P. Solere IRIS Services, 14 rue de Bezons, 92415, Courbevoie, Cédex, France
&
C. Lucas IRIS Services, 14 rue de Bezons, 92415, Courbevoie, Cédex, France
 show all
Pages 871-880 | Received 31 Jul 1991, Accepted 21 Feb 1992, Published online: 22 Sep 2008

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Caroline Chemin, Jean-Manuel Péan, Alain Le Pape, Jean-Marie Delbos, Michèle German-Fattal, Patrick Wüthrich & Patrick Couvreur. (2010) Biodistribution and anticancer activity of a new vinca alkaloid encapsulated into long-circulating liposomes. Journal of Liposome Research 20:1, pages 62-72.
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J. A. Bell & M. H. Tarbit. (1992) Twenty years on: a review of the current practice of drug metabolism and pharmacokinetic studies in the pharmaceutical industry. Xenobiotica 22:7, pages 735-742.
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Articles from other publishers (1)

Robert M. J. Ings. 1994. Use of Mechanistic Information in Risk Assessment. Use of Mechanistic Information in Risk Assessment 233 241 .

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