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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 11
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Original Article

Comparative biodisposition and metabolism of 14C-(±)-fenfluramine in mouse, rat, dog and man

N. C. Marchant Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
M. A. Breen Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
D. Wallace Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
S. Bass Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
A. R. Taylor Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
R. M. J. Ings Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
D. B. Campbell Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
&
J. Williams Department of Haematology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, UK
 show all
Pages 1251-1266 | Received 08 Oct 1991, Accepted 20 Mar 1992, Published online: 23 Apr 2010

Citations (22)

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Murali Subramanian, Vishwanath Kurawattimath, Krishna Pocha, Chris Freeden, Indranil Rao, T. Thanga Mariappan, Punit H. Marathe, Reeba K. Vikramadithyan, Pamela Abraham, Chetan P. Kulkarni, Prasanna Katnapally, Ravikumar Nutakki, Sundeep Paruchury, Priyadeep Bhutani & Sandhya Mandlekar. (2014) Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats. Xenobiotica 44:12, pages 1108-1116.
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Richard B Rothman & Michael H Baumann. (2009) Serotonergic drugs and valvular heart disease. Expert Opinion on Drug Safety 8:3, pages 317-329.
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Charles S. Grob. (2000) Deconstructing Ecstasy: The Politics Of Mdma Research. Addiction Research 8:6, pages 549-588.
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S. Caccia, A. Bergami, C. Fracasso, S. Garattini & B. Campbell. (1995) Oral kinetics of dexfenfluramine and dexnorfenfluramine in non-human primates. Xenobiotica 25:10, pages 1143-1150.
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Articles from other publishers (18)

Jo Sourbron & Lieven Lagae. (2023) Fenfluramine: a plethora of mechanisms?. Frontiers in Pharmacology 14.
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Deepak Dalvie & Sekhar Surapaneni. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 239 247 .
Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye, Brian W. Ogilvie, Steven Smith & Brooks Boyd. (2022) In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions. Pharmacology Research & Perspectives 10:3.
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Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye, Seema Muranjan, Brian W. Ogilvie, Steven Smith & Brooks Boyd. (2022) In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. Pharmacology Research & Perspectives 10:3.
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Jing Li, Maxim Nelis, Jo Sourbron, Daniëlle Copmans, Lieven Lagae, Deirdre Cabooter & Peter A. M. de Witte. (2021) Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochemical Research 46:9, pages 2249-2261.
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Donald J. AbrahamDeepak K. Dalvie & Bernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 139 .
Donald G. Barceloux. 2012. Medical Toxicology of Drug Abuse. Medical Toxicology of Drug Abuse 255 274 .
Mario Thevis, Gerd Sigmund, Vassilios Gougoulidis, Simon Beuck, Nils Schlörer, Andreas Thomas, Dorota Kwiatkowska, Andrzej Pokrywka & Wilhelm Schänzer. (2010) Screening for benfluorex and its major urinary metabolites in routine doping controls. Analytical and Bioanalytical Chemistry 401:2, pages 543-551.
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Richard B Rothman & Michael H Baumann. (2009) Appetite Suppressants, Cardiac Valve Disease and Combination Pharmacotherapy. American Journal of Therapeutics 16:4, pages 354-364.
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Michelle D. Lee, Elizabeth M. Somerville, Guy A. Kennett, Colin T. Dourish & Peter G. Clifton. (2004) Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology 176:1, pages 39-49.
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Richard B. Rothman, Robert D. Clark, John S. Partilla & Michael H. Baumann. (2003) (+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepinephrine Transporters. Journal of Pharmacology and Experimental Therapeutics 305:3, pages 1191-1199.
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Simona Bělohlávková, Jan Šimák, Alena Kokešová, Olga Hniličková & Václav Hampl. (2001) Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels. Journal of Applied Physiology 91:2, pages 755-761.
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B. Campbell, B. Dard-Brunelle & S. Caccia. 1996. Obesity Management and Redux. Obesity Management and Redux 65 80 .
C. Fracasso, G. Guiso, S. Confalonieri, A. Bergami, S. Garattini & S. Caccia. (1995) Depletion and time-course of recovery of brain serotonin after repeated subcutaneous dexfenfluramine in the mouse. A comparison with the rat. Neuropharmacology 34:12, pages 1653-1659.
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D. Bruce Campbell. (1995) The use of toxicokinetics for the safety assessment of drugs acting in the brain. Molecular Neurobiology 11:1-3, pages 193-216.
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M. Anelli, C. Fracasso, A. Bergami, A. Ferrarese, S. Garattini & S. Caccia. (1995) Effect ofd-fenfluramine on the indole contents of the rat brain after treatment with different inducers of cytochrome P450 isoenzymes. Psychopharmacology 118:2, pages 188-194.
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D. Bruce Campbell. (1995) Are interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary. Neurochemistry International 26:2, pages 103-110.
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Neil E. Rowland. (1994) Long-term administration of dexfenfluramine to genetically obese (ob/ob) and lean mice: Body weight and brain serotonin changes. Pharmacology Biochemistry and Behavior 49:2, pages 287-294.
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