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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 12
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Research Article

Rat liver microsomal metabolism of 2-halogenated 4-methylanilines

S. Boeren Department of Biochemistry, Agricultural University, Dreijenlaan 3, 6703, HA, Wageningen, The Netherlands
,
B. Tyrakowska Department of Biochemistry, Agricultural University, Dreijenlaan 3, 6703, HA, Wageningen, The Netherlands
,
J. Vervoort Department of Biochemistry, Agricultural University, Dreijenlaan 3, 6703, HA, Wageningen, The Netherlands
,
E. de Hoffman Université Catholique de Louvain, Department of Mass Spectrometry, Place Louis Pasteur 1, B-1348, Louvain-la-Neuve, Belgium
,
K. Teunis Department of Organic Chemistry, Agricultural University, Dreijenplein 8, 6703, BC, Wageningen, The Netherlands
,
A. Van Veldhuizen Department of Organic Chemistry, Agricultural University, Dreijenplein 8, 6703, BC, Wageningen, The Netherlands
&
I. M. C. M. Rietjens Department of Biochemistry, Agricultural University, Dreijenlaan 3, 6703, HA, Wageningen, The Netherlands
 show all
Pages 1403-1423 | Received 02 Jan 1992, Accepted 01 Jul 1992, Published online: 22 Sep 2008

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Yasushi Yamazoe, Kazumi Ito & Kouichi Yoshinari. (2011) Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order. Drug Metabolism Reviews 43:4, pages 409-439.
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Articles from other publishers (5)

Zvi RappoportDerek V. Banthorpe. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Olga Zakharieva, Michael Grodzicki, Alfred X Trautwein, Cees Veeger & Ivonne M.C.M Rietjens. (1998) Molecular orbital study of porphyrin–substrate interactions in cytochrome P450 catalysed aromatic hydroxylation of substituted anilines. Biophysical Chemistry 73:3, pages 189-203.
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Janneke Koerts, Sjef Boeren, Jacques Vervoort, Raymond Weiss, Cees Veeger & Ivonne M.C.M. Rietjens. (1996) Interaction between the substrate and the high-valent-iron-oxo porphyrin cofactor as a possible factor influencing the regioselectivity of cytochrome P450 catalysed aromatic ring hydroxylation of 3-fluoro(methyl)anilines. Chemico-Biological Interactions 99:1-3, pages 129-146.
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Janneke Koerts, Ivonne M.C.M. Rietjens, Marelle G. Boersma & Jacques Vervoort. (1995) 1 H NMR T 1 relaxation rate study on substrate orientation of fluoromethylanilines in the active sites of microsomal and purified cytochromes P 450 1A1 and 2B1 . FEBS Letters 368:2, pages 279-284.
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Bohdan Markus & Chul‐Hoon Kwon. (1994) In Vitro Metabolism of Aromatic Nitriles. Journal of Pharmaceutical Sciences 83:12, pages 1729-1734.
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