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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 1
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Research Article

Interaction of some peroxisome proliferators with the mouse liver peroxisome proliferator-activated receptor (PPAR): a molecular modelling and quantitative structure-activity relationship (QSAR) study

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Pages 79-96 | Received 17 Jun 1992, Accepted 31 Aug 1992, Published online: 22 Sep 2008

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D. F. V. Lewis, C. Ioannides & D. V. Parke. (1998) An Improved and Updated Version of the Compact Procedure for the Evaluation of P450-Mediated Chemical Activation. Drug Metabolism Reviews 30:4, pages 709-737.
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O. Sabzevari, M. Hatcher, M. O'sullivan, P. Kentish & G. Gibson. (1995) Comparative induction of cytochrome P4504A in rat hepatocyte culture by the peroxisome proliferators, bifonazole and clofibrate. Xenobiotica 25:4, pages 395-403.
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Articles from other publishers (22)

Piotr Zabielski, Marcin Baranowski, Małgorzata Żendzian-Piotrowska, Agnieszka Błachnio-Zabielska & Jan Górski. (2008) Bezafibrate decreases growth stimulatory action of the sphingomyelin signaling pathway in regenerating rat liver. Prostaglandins & Other Lipid Mediators 85:1-2, pages 17-25.
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Christopher J. Sinal, Michung Yoon & Frank J. Gonzalez. (2001) Antagonism of the Actions of Peroxisome Proliferator-activated Receptor-α by Bile Acids. Journal of Biological Chemistry 276:50, pages 47154-47162.
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David F?V Lewis. (2001) COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics. Journal of Chemical Technology & Biotechnology 76:3, pages 237-244.
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Sloboda Dzhekova-Stojkova, Jasna Bogdanska & Zana Stojkova. (2001) Peroxisome Proliferators: Their Biological and Toxicological Effects. Clinical Chemistry and Laboratory Medicine 39:6.
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D.F.V Lewis & B.G Lake. (1998) Molecular modelling of the rat peroxisome proliferator-activated receptor -α (rPPARα) by homology with the human retinoic acid X receptor α (hRXRα) and investigation of ligand binding interactions I: QSARs. Toxicology in Vitro 12:6, pages 619-632.
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D.F.V Lewis, C Ioannides & D.V Parke. (1998) Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicals. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 412:1, pages 41-54.
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John C. Dearden, Martin D. Barratt, Romualdo Benigni, Douglas W. Bristol, Robert D. Combes, Mark T.D. Cronin, Philip N. Judson, Martin P. Payne, Ann M. Richard, Milon Tichy, Andrew P. Worth & Jeffrey J. Yourick. (2020) The Development and Validation of Expert Systems for Predicting Toxicity. Alternatives to Laboratory Animals 25:3, pages 223-251.
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D.F.V. Lewis & B.G. Lake. (1997) Quantitative structure-activity relationship (QSAR) analysis for a series of rodent peroxisome proliferators: Interaction with the mouse liver peroxisome proliferator-activated receptor α (mPPARα). Toxicology in Vitro 11:1-2, pages 99-105.
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Paul Dowell, Valerie J. Peterson, T. Mark Zabriskie & Mark Leid. (1997) Ligand-induced Peroxisome Proliferator-activated Receptor α Conformational Change. Journal of Biological Chemistry 272:3, pages 2013-2020.
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D. F. V. Lewis. 1997. Food Chemical Risk Analysis. Food Chemical Risk Analysis 163 194 .
G. GORDON GIBSON. (1996) Peroxisome Proliferators and Cytochrome P4504A Induction. Annals of the New York Academy of Sciences 804:1 Peroxisomes, pages 328-340.
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D F Lewis, C Ioannides & D V Parke. (1996) COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP.. Environmental Health Perspectives 104:suppl 5, pages 1011-1016.
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D.F.V. Lewis & G.R. Langley. (1996) A validation study of the COMPACT and HazardExpert techniques with 40 chemicals. Mutation Research/Genetic Toxicology 369:3-4, pages 157-174.
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D. J. Fretland, C. P. Anglin, D. Widomski, D. A. Baron, T. Maziasz & P. F. Smith. (1995) Pharmacological activity of the second generation leukotriene B4 receptor antagonist, SC-53228:. Inflammation 19:5, pages 503-515.
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D F LewisC IoannidesD V Parke. (1995) A retrospective evaluation of COMPACT predictions of the outcome of NTP rodent carcinogenicity testing.. Environmental Health Perspectives 103:2, pages 178-184.
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Takashi Makita. 1995. 303 352 .
David F.V. Lewis, Malcolm G. Parker & Roger J.B. King. (1995) Molecular modelling of the human estrogen receptor and ligand interactions based on site-directed mutagenesis and amino acid sequence homology. The Journal of Steroid Biochemistry and Molecular Biology 52:1, pages 55-65.
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Edwin Chinje, Peter Kentish, Bruce Jarnot, Marilyn George & Gordon Gibson. (1994) Induction of the CYP4A subfamily by perfluorodecanoic acid: the rat and the guinea pig as susceptible and non-susceptible species. Toxicology Letters 71:1, pages 69-75.
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J. Ashby, A. Brady, C.R. Elcombe, B.M. Elliott, J. Ishmael, J. Odum, J.D. Tugwood, S. Kettle & I.F.H. Purchase. (2017) Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis. Human & Experimental Toxicology 13:2_suppl, pages S1-S117.
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Eleni Rekka, Edward O. Ayalogu, David F. V. Lewis, Gordon G. Gibson & Costas Ioannides. (1994) Induction of hepatic microsomal CYP4A activity and of peroxisomal β-oxidation by two non-steroidal anti-inflammatory drugs. Archives of Toxicology 68:2, pages 73-78.
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B.G. Lake, D.F.V. Lewis, T.J.B. Gray & J.A. Beamand. (1993) Structure-activity relationships for induction of peroxisomal enzyme activities in primary rat hepatocyte cultures. Toxicology in Vitro 7:5, pages 605-614.
Crossref
Maria J. Diaz, Edwin Chinje, Peter Kentish, Bruce Jarnot, Marilyn George & G. Gordon Gibson. (1993) Chlorotrifluoroethylene trimer and tetramer are inducers of the CYP4A subfamily. Biochemical Pharmacology 46:6, pages 1076-1080.
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