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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 2
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Research Article

Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system

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Pages 141-153 | Received 20 May 1992, Accepted 03 Oct 1992, Published online: 22 Sep 2008

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Christoffel Petrus Stephanus Badenhorst, Elardus Erasmus, Rencia van der Sluis, Carla Nortje & Alberdina Aike van Dijk. (2014) A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids. Drug Metabolism Reviews 46:3, pages 343-361.
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Christoffel Petrus Stephanus Badenhorst, Rencia van der Sluis, Elardus Erasmus & Alberdina Aike van Dijk. (2013) Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1139-1153.
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Kathleen M Knights, Matthew J Sykes & John O Miners. (2007) Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acids. Expert Opinion on Drug Metabolism & Toxicology 3:2, pages 159-168.
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Articles from other publishers (26)

Stefan Kühn, Monray E. Williams, Marli Dercksen, Jörn Oliver Sass & Rencia van der Sluis. (2023) The glycine N-acyltransferases, GLYAT and GLYATL1, contribute to the detoxification of isovaleryl-CoA - an in-silico and in vitro validation. Computational and Structural Biotechnology Journal 21, pages 1236-1248.
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Rencia van der Sluis & Kathleen M. Knights. 2023. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Johann M. Rohwer, Chantelle Schutte & Rencia van der Sluis. (2021) Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl–CoA. International Journal of Molecular Sciences 22:6, pages 3129.
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Robert L. Smith, Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, Stephen S. Hecht, F. Peter Guengerich, Ivonne M. C. M. Rietjens, Maria Bastaki, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2018) The safety evaluation of food flavouring substances: the role of metabolic studies. Toxicology Research 7:4, pages 618-646.
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K.M. Knights. 2018. Comprehensive Toxicology. Comprehensive Toxicology 517 540 .
Rencia van der Sluis, Vida Ungerer, Carla Nortje, Alberdina A. van Dijk & Elardus Erasmus. (2017) New insights into the catalytic mechanism of human glycine N‐acyltransferase. Journal of Biochemical and Molecular Toxicology 31:11.
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Carla Nortje, Rencia van der Sluis, Alberdina Aike van Dijk & Elardus Erasmus. (2016) The Use of p -Aminobenzoic Acid as a Probe Substance for the Targeted Profiling of Glycine Conjugation . Journal of Biochemical and Molecular Toxicology 30:3, pages 136-147.
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Hannah J. Lees, Jonathan R. Swann, Ian D. Wilson, Jeremy K. Nicholson & Elaine Holmes. (2013) Hippurate: The Natural History of a Mammalian–Microbial Cometabolite. Journal of Proteome Research 12:4, pages 1527-1546.
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Michael Lyon. 2013. Textbook of Natural Medicine. Textbook of Natural Medicine 475 487 .
Diren Beyoğlu & Jeffrey R. Idle. (2012) The glycine deportation system and its pharmacological consequences. Pharmacology & Therapeutics 135:2, pages 151-167.
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Alexander V. LyubimovKathleen M. Knights & John O. Miners. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 16 .
. (2011) Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14. EFSA Journal 9:8, pages 2313.
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Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant & Angela Mally. (2010) Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats. Drug Metabolism and Disposition 38:10, pages 1698-1706.
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. (2010) Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side‐chain substituents and heteroatoms from chemical group 14. EFSA Journal 8:4.
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K.M. Knights & D.A. Vessey. 2010. Comprehensive Toxicology. Comprehensive Toxicology 459 483 .
. (2009) Flavouring Group Evaluation 14, Revision 1 (FGE.14Rev1): Phenethyl alcohol, aldehyde, acetals, carboxylic acid and related esters from chemical group 15 and 22 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials. EFSA Journal 7:1, pages 930.
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Karen J. Marsh, Ian R. Wallis, Rose L. Andrew & William J. Foley. (2006) The Detoxification Limitation Hypothesis: Where Did it Come From and Where is it Going?. Journal of Chemical Ecology 32:6, pages 1247-1266.
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Karen J. Marsh, Ian R. Wallis & William J. Foley. (2005) DETOXIFICATION RATES CONSTRAIN FEEDING IN COMMON BRUSHTAIL POSSUMS (TRICHOSURUS VULPECULA). Ecology 86:11, pages 2946-2954.
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J. L. K. Van Hove, K. Vande Kerckhove, J. B. Hennermann, V. Mahieu, P. Declercq, S. Mertens, M. De Becker, P. S. Kishnani & J. Jaeken. (2005) Benzoate treatment and the glycine index in nonketotic hyperglycinaemia. Journal of Inherited Metabolic Disease 28:5, pages 651-663.
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T.B. Adams, S.M. Cohen, J. Doull, V.J. Feron, J.I. Goodman, L.J. Marnett, I.C. Munro, P.S. Portoghese, R.L. Smith, W.J. Waddell & B.M. Wagner. (2005) The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients. Food and Chemical Toxicology 43:8, pages 1179-1206.
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. (2005) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to: Flavouring Group Evaluation 14 (FGE.14): Phenethyl alcohol, aldehyde, esters, and related phenylacetic acid esters from ch. EFSA Journal 3:7, pages 216.
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. (2005) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 13 (FGE.13); Furfuryl and furan derivatives with and without additional side-chain substituents. EFSA Journal 3:7, pages 215.
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Cecilia Zuppi, Irene Messana, Franca Forni, Franco Ferrari, Cristina Rossi & Bruno Giardina. (1998) Influence of feeding on metabolite excretion evidenced by urine 1 H NMR spectral profiles: a comparison between subjects living in Rome and subjects living at arctic latitudes (Svaldbard). Clinica Chimica Acta 278:1, pages 75-79.
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T.B. Adams, J. Doull, J.I. Goodman, I.C. Munro, P. Newberne, P.S. Portoghese, R.L. Smith, B.M. Wagner, C.S. Weil, L.A. Woods & R.A. Ford. (1997) The FEMA GRAS assessment of furfural used as a flavour ingredient. Food and Chemical Toxicology 35:8, pages 739-751.
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M.K. Parkash & J. Caldwell. (1994) Metabolism and excretion of [14C]furfural in the rat and mouse. Food and Chemical Toxicology 32:10, pages 887-895.
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Manju Tandon, Piyush Kumar & Leonard I. Wiebe. (1994) α-trifluoromethyl-β-alanyl glycine (F3MBAG): A novel mammalian metabolite of trifluridine (F3TdR). Biochemical Pharmacology 48:5, pages 1033-1041.
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