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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 2
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Research Article

Effect of treatment with pyrazine and some derivatives on cytochrome P450 and some enzyme activities in rat liver

A. C. Japenga Department of Toxicology, Wageningen Agricultural University, Tuinlaan, 5, 6703 HE, Wageningen, The Netherlands
,
S. Davies BIBRA Toxicology International, Woodmansterne Road, Carshalton, Surrey, SM5 4DS, UK
,
R. J. Price BIBRA Toxicology International, Woodmansterne Road, Carshalton, Surrey, SM5 4DS, UK
&
B. G. Lake BIBRA Toxicology International, Woodmansterne Road, Carshalton, Surrey, SM5 4DS, UK
Pages 169-179 | Received 16 Jul 1992, Accepted 30 Oct 1992, Published online: 22 Sep 2008

Citations (18)

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Read on this site (4)

C. Meredith, M. P. Scott, A. B. Renwick, R. J. Price & B. G. Lake. (2003) Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices. Xenobiotica 33:5, pages 511-527.
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A. B. Renwick, G. Lavignette, P. D. Worboys, B. Williams, D. Surry, D. F. V. Lewis, R. J. Price, B. G. Lake & D. C. Evans. (2001) Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica 31:12, pages 861-878.
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B. G. Lake, C. Charzat, J. M. Tredger, A. B. Renwick, J. A. Beamand & R. J. Price. (1996) Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices. Xenobiotica 26:3, pages 297-306.
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T. G. Altunas & J. W. Gorrod. (1996) Effect of various potential inhibitors, activators and inducers on the N-oxidation of isomeric aromatic diazines in vitro using rabbit liver microsomal preparations. Xenobiotica 26:1, pages 9-15.
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Articles from other publishers (14)

Brian G. Lake, Roger J. Price, Mary P. Scott, Lynsey R. Chatham, Audrey Vardy & Thomas G. Osimitz. (2020) Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance. Toxicology 439, pages 152465.
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Richard C Peffer, David E Cowie, Richard A Currie & Daniel J Minnema. (2018) Sedaxane—Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors. Toxicological Sciences 162:2, pages 582-598.
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Rob Stierum, Ana Conesa, Wilbert Heijne, Ben van Ommen, Karin Junker, Mary P. Scott, Roger J. Price, Clive Meredith, Brian G. Lake & John Groten. (2008) Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole. Food and Chemical Toxicology 46:8, pages 2616-2628.
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Takayuki Uchimoto, Sakae Itoga, Masahiko Nezu, Masahiko Sunaga, Takeshi Tomonaga & Fumio Nomura. (2007) Role of the Genetic Polymorphisms in the 5'-Flanking Region for Transcriptional Regulation of the Human CYP2E1 Gene. Alcoholism: Clinical and Experimental Research 31:s1, pages S36-S42.
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Roger J. Price, David G. Walters, John M. Finch, Karl L. Gabriel, Charles C. Capen, Thomas G. Osimitz & Brian G. Lake. (2007) A mode of action for induction of liver tumors by Pyrethrins in the rat. Toxicology and Applied Pharmacology 218:2, pages 186-195.
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Roger J. Price, Mary P. Scott, David G. Walters, Rob H. Stierum, John P. Groten, Clive Meredith & Brian G. Lake. (2004) Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes. Food and Chemical Toxicology 42:6, pages 899-908.
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T.B Adams, J Doull, V.J Feron, J.I Goodman, L.J Marnett, I.C Munro, P.M Newberne, P.S Portoghese, R.L Smith, W.J Waddell & B.M Wagner. (2002) The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Food and Chemical Toxicology 40:4, pages 429-451.
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A.B. Renwick, H. Mistry, P.T. Barton, F. Mallet, R.J. Price, J.A. Beamand & B.G. Lake. (1999) Effect of some Indole Derivatives on Xenobiotic Metabolism and Xenobiotic-induced Toxicity in Cultured Rat Liver Slices. Food and Chemical Toxicology 37:6, pages 609-618.
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Brian G. Lake, Anthony B. Renwick, Morag E. Cunninghame, Roger J. Price, Dominic Surry & David C. Evans. (1998) Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver. Toxicology 131:1, pages 9-20.
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Nobumitsu Hanioka, Kyoko Nakano, Hideto Jinno, Masao Hamamure, Atsuko Takahashi, Reiko Yoda, Tetsuji Nishimura & Masanori Ando. (1995) Induction of hepatic drug-metabolizing enzymes by chlornitrofen (CNP) and cnp- amino in rats and mice. Chemosphere 30:7, pages 1297-1309.
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Nobumitsu Hanioka, Hideto Jinno, Toshimasa Toyo'oka & Masanori Ando. (1994) The effect of 1,2,3,4-tetrachlorodibenzo-p-dioxin on drug-metabolizing enzymes in the rat liver. Chemosphere 29:12, pages 2477-2491.
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Nobumitsu Hanioka, Hideto Jinno, Toshimasa Toyo'oka & Masanori Ando. (1994) Effect of 1,2,4-trichlorodibenzo-p-dioxin on drug-metabolizing enzymes in the rat liver. Chemosphere 29:6, pages 1313-1324.
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J.A. Beamand, P.T. Wield, C.A. Morin, H. Mistry, S. Davies, R.J. Price & B.G. Lake. (1994) Induction of mixed function oxidase activities in Cynomolgus monkey hepatocyte cultures. Toxicology in Vitro 8:4, pages 549-550.
Crossref
B.G. Lake, J.A. Beamand, M.E. Cunninghame, S. Davies, H. Mistry & R.J. Price. (1994) Effect of peroxisome proliferators and inducers of xenobiotic metabolism on marker enzyme activities in cultured rat liver slices. Toxicology in Vitro 8:4, pages 521-523.
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