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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 5
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Research Article

Studies on the metabolism of a monoterpene ketone, R-(+)-pulegone-a hepatotoxin in rat: isolation and characterization of new metabolites

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Pages 509-518 | Received 28 Aug 1992, Accepted 21 Jan 1993, Published online: 22 Sep 2008

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Read on this site (7)

K.B. Rameshkumar, D.B. Alan Sheeja, Mangalam S. Nair & V. George. (2015) Curcuma ecalcarata – new natural source of pinocembrin and piperitenone. Natural Product Research 29:13, pages 1276-1279.
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Ling-Jen Chen Ferguson, EdwardH. Lebetkin, FredB. Lih, KennethB. Tomer, HoraceD. Parkinson, SusanJ. Borghoff & LeoT. Burka. (2007) 14C-labeled Pulegone and Metabolites Binding to α2u-globulin in Kidneys of Male F-344 Rats∗ . Journal of Toxicology and Environmental Health, Part A 70:17, pages 1416-1423.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Peter J. O'Brien, Arno G. Siraki & Nandita Shangari. (2005) Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health. Critical Reviews in Toxicology 35:7, pages 609-662.
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K. M. MADYASTHA NILESH & W. GAIKWAD. (1998) Metabolic fate of S-(-)-pulegone in rat. Xenobiotica 28:8, pages 723-734.
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Articles from other publishers (25)

Nico D. Fessner, Hansjörg Weber & Anton Glieder. (2022) Regiospecific 7-hydroxylation of ten-carbon monoterpenes by detoxifying CYP5035S7 monooxygenase of the white-rot fungus Polyporus arcularius. Biochemical and Biophysical Research Communications 595, pages 35-40.
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Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Maria Bastaki, Jeanne M. Davidsen, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2020) FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients. Food and Chemical Toxicology 135, pages 110870.
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Tomáš Zárybnický, Iva Boušová, Martin Ambrož & Lenka Skálová. (2017) Hepatotoxicity of monoterpenes and sesquiterpenes. Archives of Toxicology 92:1, pages 1-13.
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Mijat Božović & Rino Ragno. (2017) Calamintha nepeta (L.) Savi and its Main Essential Oil Constituent Pulegone: Biological Activities and Chemistry. Molecules 22:2, pages 290.
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Ayoub Kasrati, Chaima Alaoui Jamali, Robert Spooner-Hart, Laurent Legendre, David Leach & Abdelaziz Abbad. (2017) Chemical Characterization and Biological Activities of Essential Oil Obtained from Mint Timija Cultivated under Mineral and Biological Fertilizers. Journal of Analytical Methods in Chemistry 2017, pages 1-7.
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. 2014. Essential Oil Safety. Essential Oil Safety 677 755 .
Robert Tisserand & Rodney Young. 2014. Essential Oil Safety. Essential Oil Safety 483 647 .
Jiří Patočka & Kamil Kuča. (2013) BIOLOGICALLY ACTIVE ALCOHOLS: CYCLIC ALCOHOLS. Military Medical Science Letters 82:4, pages 162-171.
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Yanina Estefanía Rossi, Lilián Canavoso & Sara María Palacios. (2012) Molecular response of Musca domestica L. to Mintostachys verticillata essential oil, (4R)(+)-pulegone and menthone. Fitoterapia 83:2, pages 336-342.
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Jian-ju Ren, Lan-qing Ma, Yu-bo Liu, Guang-lu Shi & You-nian Wang. 2012. Information Technology and Agricultural Engineering. Information Technology and Agricultural Engineering 565 576 .
S. Cyrus Khojasteh, Shimako Oishi & Sidney D. Nelson. (2010) Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats. Chemical Research in Toxicology 23:11, pages 1824-1832.
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Bharti Sapra, Subheet Jain & A. K. Tiwary. (2008) Percutaneous Permeation Enhancement by Terpenes: Mechanistic View. The AAPS Journal 10:1.
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Raymond A. Kemper, Diane L. Nabb, Shawn A. Gannon, Timothy A. Snow & Anne Marie Api. (2006) COMPARATIVE METABOLISM OF GERANYL NITRILE AND CITRONELLYL NITRILE IN MOUSE, RAT, AND HUMAN HEPATOCYTES. Drug Metabolism and Disposition 34:6, pages 1019-1029.
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. (2016) Final Report on the Safety Assessment of Sodium p -Chloro- m -Cresol, p -Chloro- m -Cresol, Chlorothymol, Mixed Cresols, m -Cresol, o -Cresol, p -Cresol, Isopropyl Cresols, Thymol, o -Cymen-5-ol, and Carvacrol1. International Journal of Toxicology 25:1_suppl, pages 29-127.
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Robert L. Smith, Samuel M. Cohen, John Doull, Victor J. Feron, Jay I. Goodman, Lawrence J. Marnett, Ian C. Munro, Philip S. Portoghese, William J. Waddell, Bernard M. Wagner & Timothy B. Adams. (2005) Criteria for the safety evaluation of flavoring substances. Food and Chemical Toxicology 43:8, pages 1141-1177.
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Shufeng Zhou, Hwee-Ling Koh, Yihuai Gao, Zhi-yuan Gong & Edmund Jon Deoon Lee. (2004) Herbal bioactivation: The good, the bad and the ugly. Life Sciences 74:8, pages 935-968.
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L.-J. Chen, E. H. Lebetkin & L. T. Burka. (2003) METABOLISM OF ( R )-(+)-MENTHOFURAN IN FISCHER-344 RATS: IDENTIFICATION OF SULFONIC ACID METABOLITES . Drug Metabolism and Disposition 31:10, pages 1208-1213.
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Wolfgang Engel. (2003) In Vivo Studies on the Metabolism of the Monoterpene Pulegone in Humans Using the Metabolism of Ingestion-Correlated Amounts (MICA) Approach:  Explanation for the Toxicity Differences between ( S )-(−)- and ( R )-(+)-Pulegone . Journal of Agricultural and Food Chemistry 51:22, pages 6589-6597.
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K.M Madyastha & C Paul Raj. (2002) Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity. Biochemical and Biophysical Research Communications 297:2, pages 202-205.
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Nilesh W. Gaikwad & K.M. Madyastha. (2002) Biosynthesis of β-Substituted Furan Skeleton in the Lower Furanoterpenoids: A Model Study. Biochemical and Biophysical Research Communications 290:1, pages 589-594.
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K. M. Madyastha & H. V. Thulasiram. (1999) Transformation of a Monoterpene Ketone, ( R )-(+)-Pulegone, a Potent Hepatotoxin, in Mucor piriformis . Journal of Agricultural and Food Chemistry 47:3, pages 1203-1207.
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Bhat.B. Vadiraja, Nilesh.W. Gaikwad & K.M. Madyastha. (1998) Hepatoprotective Effect of C-Phycocyanin: Protection for Carbon Tetrachloride andR-(+)-Pulegone-Mediated Hepatotoxicty in Rats. Biochemical and Biophysical Research Communications 249:2, pages 428-431.
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T.B. Adams, D.B. Greer, J. Doull, I.C. Munro, P. Newberne, P.S. Portoghese, R.L. Smith, B.M. Wagner, C.S. Weil, L.A. Woods & R.A. Ford. (1998) The FEMA GRAS Assessment of Lactones Used as Flavour Ingredients. Food and Chemical Toxicology 36:4, pages 249-278.
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T.B. Adams, J.B. Hallagan, J.M. Putnam, T.L. Gierke, J. Doull, I.C. Munro, P. Newberne, P.S. Portoghese, R.L. Smith, B.M. Wagner, C.S. Weil, L.A. Woods & R.A. Ford. (1996) The FEMA GRAS assessment of alicyclic substances used as flavour ingredients. Food and Chemical Toxicology 34:9, pages 763-828.
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K. Madhava Madyastha & C.Paul Raj. (1994) Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes, in vivo. Toxicology 89:2, pages 119-125.
Crossref

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