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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 6
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Research Article

Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents

L. Koymans Divisions of Design and Synthesis and Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands
,
G. M. Donné-Op Den Kelder Divisions of Design and Synthesis and Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands
,
J. M. Te Koppele Divisions of Design and Synthesis and Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands
&
N. P. E. Vermeulen Divisions of Design and Synthesis and Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands
Pages 633-648 | Received 02 Sep 1992, Accepted 20 Mar 1993, Published online: 22 Sep 2008

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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Jos G. M. Bessems & Nico P. E. Vermeulen. (2001) Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches. Critical Reviews in Toxicology 31:1, pages 55-138.
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L. Dihel, C. Kittleson, K. Mulvihill & W. W. Johnson. (2009) Oxidative Metabolism of the Trifluoromethoxy Moiety of OSI-930. Drug Metabolism and Drug Interactions 24:2-4.
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Andrew W. Munro, Hazel M. Girvan & Kirsty J. McLean. (2007) Variations on a (t)heme—novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily. Nat. Prod. Rep. 24:3, pages 585-609.
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Ulrik Jurva, Håkan V. Wikström, Lars Weidolf & Andries P. Bruins. (2003) Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions. Rapid Communications in Mass Spectrometry 17:8, pages 800-810.
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M.D Tingle, R Mahmud, J.L Maggs, S Hawley, M.D Coleman, S.A Ward & B.K Park. (1998) The effect of 2,2′-substitution on the metabolism and toxicity of dapsone in vitro and in vivo. Environmental Toxicology and Pharmacology 5:2, pages 145-153.
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R. Mahmud, M.D. Tingle, J.L. Maggs, M.T.D. Cronin, J.C. Dearden & B.K. Park. (1997) Structural basis for the haemotoxicity of dapsone: the importance of the sulphonyl group. Toxicology 117:1, pages 1-11.
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David C. Thompson, Kumar Perera & Robert London. (1996) Studies on the mechanism of hepatotoxicity of 4-methylphenol (p-cresol): effects of deuterium labeling and ring substitution. Chemico-Biological Interactions 101:1, pages 1-11.
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V Maurich, M De Amici, C De Micheli & P Rossato. (1995) Identification and full characterization of a new metabolite of metoclopramide. European Journal of Medicinal Chemistry 30:10, pages 757-762.
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Elisabetta Chieli, Michela Saviozzi, Silvia Menicagli, Teresa Branca & Pier Giovanni Gervasi. (1995) Hepatotoxicity and P-4502E1-dependent metabolic oxidation of N,N-dimethylformamide in rats and mice. Archives of Toxicology 69:3, pages 165-170.
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