Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 8
Submit an article Journal homepage
92
Views
46
CrossRef citations to date
0
Altmetric
Original Article

Glutathione-dependent bioactivation of xenobiotics

W. Dekant Institut für Toxikologie und Pharmakologie, Universität Würzburg, Versbacher Str. 9, 8700, Würzburg, Germany
&
S. Vamvakas Institut für Toxikologie und Pharmakologie, Universität Würzburg, Versbacher Str. 9, 8700, Würzburg, Germany
Pages 873-887 | Received 02 Mar 1993, Accepted 30 Apr 1993, Published online: 23 Apr 2010

Citations (46)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Serdar Karakurt, Asli Semiz, Gurbet Celik, Ayse Mine Gencler-Ozkan, Alaattin Sen & Orhan Adali. (2016) Contribution of ellagic acid on the antioxidant potential of medicinal plant Epilobium hirsutum. Nutrition and Cancer 68:1, pages 173-183.
Read now
Mesut Aydin, Abdulkadir Yildiz, Ibrahim Ibiloglu, Aysun Ekinci, Burak Veli Ulger, Murat Yuksel, Mehmet Zihni Bilik, Necdet Ozaydogdu, Cenap Ekinci & Umit Can Yazgan. (2015) The protective role of glutamine against acute induced toxicity in rats. Toxicology Mechanisms and Methods 25:4, pages 296-301.
Read now
D. Italibi Uraga-Tovar, M. Lilia Domínguez-López, Ruth L. Madera-Sandoval, Minerva Nájera-Martínez, Ethel García-Latorre & Armando Vega-López. (2014) Generation of oxyradicals ( and H2O2), mitochondrial activity and induction of apoptosis of PBMC of Cyprinus carpio carpio treated in vivo with halomethanes and with recombinant HSP60 kDa and with LPS of Klebsiella pneumoniae. Immunopharmacology and Immunotoxicology 36:5, pages 329-340.
Read now
Minerva Nájera-Martínez, Ethel A. García-Latorre, Elba Reyes-Maldonado, M. Lilia Domínguez-López & Armando Vega-López. (2012) Halomethane-induced cytotoxicity and cell proliferation in human lung MRC-5 fibroblasts and NL20-TA epithelial cells. Inhalation Toxicology 24:11, pages 762-773.
Read now
P. Kestell & S.C. Mitchell. (1996) The Toxicity of Sulfonium Compounds. Sulfur reports 17:2, pages 159-176.
Read now
Aleksandrs Odinecs, Stefano Maso, Giampaolo Nicoletto, Livia Secondin & Andrea Trevisan. (1995) Mechanism of Sex-Related Differences in Nephrotoxicity of 1,2-Dichloropropane in Rats. Renal Failure 17:5, pages 517-524.
Read now

Articles from other publishers (40)

Lucina E. Lizarraga, Glenn W. Suter, Jason C. Lambert, Grace Patlewicz, Jay Q. Zhao, Jeffry L. Dean & Phillip Kaiser. (2023) Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods. Regulatory Toxicology and Pharmacology 137, pages 105293.
Crossref
Rahul Raj Singh & Katie M. Reindl. (2021) Glutathione S-Transferases in Cancer. Antioxidants 10:5, pages 701.
Crossref
Hai He, Elad Noor, Perla A. Ramos-Parra, Liliana E. García-Valencia, Jenelle A. Patterson, Rocío I. Díaz de la Garza, Andrew D. Hanson & Arren Bar-Even. (2020) In Vivo Rate of Formaldehyde Condensation with Tetrahydrofolate. Metabolites 10:2, pages 65.
Crossref
Chang-Hwei ChenChang-Hwei Chen. 2020. Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense. Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense 95 108 .
Chang-Hwei ChenChang-Hwei Chen. 2020. Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense. Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense 71 81 .
Marcelo Farina & Michael Aschner. (2019) Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay. Biochimica et Biophysica Acta (BBA) - General Subjects 1863:12, pages 129285.
Crossref
Peixin Tang, Maria Trinidad Gomez, Ho Ting Leung & Gang Sun. (2019) Bio-inspired ultrasensitive colorimetric detection of methyl isothiocyanate on nylon-6 nanofibrous membrane: A comparison of biological thiol reactivities. Journal of Hazardous Materials 362, pages 375-382.
Crossref
Françoise Guéraud. (2017) 4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer. Free Radical Biology and Medicine 111, pages 196-208.
Crossref
Stephanie M. TortorellaSimon G. RoycePaul V. LicciardiTom C. Karagiannis. (2015) Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. Antioxidants & Redox Signaling 22:16, pages 1382-1424.
Crossref
Amaeze H. Nnamdi, Adebesin A. Olumide, Adepegba E. Adeladun, Kolapo Oyenike & Egonmwan I. Rosemary. (2015) The use of antioxidative stress enzymes, lipid peroxidation, and red blood cell abnormalities as biomarkers of stress in Periphthalmus papilio of the polluted coastal Lagos lagoon. Environmental Monitoring and Assessment 187:3.
Crossref
Cahfer Güloğlu. (2015) Glutamine Provides Effective Protection Against Deltamethrin-Induced Acute Hepatotoxicity in Rats But Not Against Nephrotoxicity. Medical Science Monitor 21, pages 1107-1114.
Crossref
Hugo F. Olivares-Rubio, M. Lysset Martínez-Torres, María Lilia Domínguez-López, Ethel García-Latorre & Armando Vega-López. (2013) Pro-oxidant and antioxidant responses in the liver and kidney of wild Goodea gracilis and their relation with halomethanes bioactivation. Fish Physiology and Biochemistry 39:6, pages 1603-1617.
Crossref
Ricardo Dzul-Caamal, Hugo F. Olivares-Rubio, Pamela López-Tapia & Armando Vega-López. (2013) Pro-oxidant and antioxidant response elicited by CH2Cl2, CHCl3 and BrCHCl2 in Goodea gracilis using non-invasive methods. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 165:4, pages 515-527.
Crossref
Junho Jeon, Denise Kurth, Roman Ashauer & Juliane Hollender. (2013) Comparative Toxicokinetics of Organic Micropollutants in Freshwater Crustaceans. Environmental Science & Technology, pages 130712083046004.
Crossref
Junho Jeon, Denise Kurth & Juliane Hollender. (2013) Biotransformation Pathways of Biocides and Pharmaceuticals in Freshwater Crustaceans Based on Structure Elucidation of Metabolites Using High Resolution Mass Spectrometry. Chemical Research in Toxicology 26:3, pages 313-324.
Crossref
A Mandegary, M Sezavar, A Saeedi, B Amirheidari & B Naghibi. (2012) Oxidative stress induced in the workers of natural gas refineries, no role for GSTM1 and GSTT1 polymorphisms. Human & Experimental Toxicology 31:12, pages 1271-1279.
Crossref
Larissa C. FaustinoNorma A. S. Almeida, Guilherme F. PereiraRafael G. RamosRaquel M. Soares, Marcelo M. MoralesCarmen C. Pazos-MouraTania M Ortiga-Carvalho. (2012) Thyroid hormone and estradiol have overlapping effects on kidney glutathione S -transferase-α gene expression . American Journal of Physiology-Endocrinology and Metabolism 303:6, pages E787-E797.
Crossref
Alexander V. LyubimovMark P. Grillo. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 56 .
Armando Vega-López, Carla I. Carrillo-Morales, Hugo F. Olivares-Rubio, M. Lilia Domínguez-López & Ethel A. García-Latorre. (2011) Evidence of Bioactivation of Halomethanes and its Relation to Oxidative Stress Response in Chirostoma riojai, an Endangered Fish from a Polluted Lake in Mexico. Archives of Environmental Contamination and Toxicology 62:3, pages 479-493.
Crossref
Chang-Hwei ChenChang-Hwei Chen. 2012. Activation and Detoxification Enzymes. Activation and Detoxification Enzymes 49 59 .
Chang-Hwei ChenChang-Hwei Chen. 2012. Activation and Detoxification Enzymes. Activation and Detoxification Enzymes 37 48 .
Premila AbrahamBina Isaac. (2010) The effects of oral glutamine on cyclophosphamide-induced nephrotoxicity in rats. Human & Experimental Toxicology 30:7, pages 616-623.
Crossref
Jeffrey K. Wickliffe, Sherif Z. Abdel-Rahman, Chul Lee, Csilla Kormos-Hallberg, Gagan Sood, Catherine M. Rondelli, James J. Grady, Robert J. Desnick & Karl E. Anderson. (2010) CYP1A2*1F and GSTM1 Alleles Are Associated with Susceptibility to Porphyria Cutanea Tarda. Molecular Medicine 17:3-4, pages 241-247.
Crossref
Yousra Souiden, Manel Mahdouani, Kamel Chaieb, Rafick Elkamel & Kacem Mahdouani. (2010) Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population. Cancer Epidemiology 34:5, pages 598-603.
Crossref
Curtis D. Klaassen & Scott A. Reisman. (2010) Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver. Toxicology and Applied Pharmacology 244:1, pages 57-65.
Crossref
John A. Timbrell & Timothy C. Marrs. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
Crossref
Duk-Hee LeeMyron D. GrossMichael W. SteffesDavid R. JacobsJrJr. (2008) Is Serum Gamma-Glutamyltransferase a Biomarker of Xenobiotics, Which Are Conjugated by Glutathione?. Arteriosclerosis, Thrombosis, and Vascular Biology 28:4.
Crossref
M. W. Anders. (2007) Chemical Toxicology of Reactive Intermediates Formed by the Glutathione-Dependent Bioactivation of Halogen-Containing Compounds. Chemical Research in Toxicology 21:1, pages 145-159.
Crossref
Zunyan Dai, Ying Huang, Wolfgang Sadee & Paul Blower. (2007) Chemoinformatics Analysis Identifies Cytotoxic Compounds Susceptible to Chemoresistance Mediated by Glutathione and Cystine/Glutamate Transport System x c - . Journal of Medicinal Chemistry 50:8, pages 1896-1906.
Crossref
Giovanni Brambilla & Antonietta Martelli. (2004) Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens. Toxicology 196:1-2, pages 1-19.
Crossref
. 2002. ATSDR's Toxicological Profiles. ATSDR's Toxicological Profiles.
Wolfgang Dekant. (2001) Chemical-induced nephrotoxicity mediated by glutathione S-conjugate formation. Toxicology Letters 124:1-3, pages 21-36.
Crossref
S.K Abraham & S.P Singh. (1999) Anti-genotoxicity and Glutathione S-transferase Activity in Mice Pretreated with Caffeinated and Decaffeinated Coffee. Food and Chemical Toxicology 37:7, pages 733-739.
Crossref
M. W. Anders & W. Dekant. (1998) GLUTATHIONE-DEPENDENT BIOACTIVATION OF HALOALKENES. Annual Review of Pharmacology and Toxicology 38:1, pages 501-537.
Crossref
J. G. Hengstler, M. Arand, M. E. Herrero & F. Oesch. 1998. Genes and Environment in Cancer. Genes and Environment in Cancer 47 85 .
Peter B. Farmer. (1997) Extended Summary Drug and Pesticide Metabolism II: New Approaches in Metabolism and Toxicology of Agro- and Industrial Chemicals. Pesticide Science 49:3, pages 300-302.
Crossref
J. Gerald Kenna & Ronald M. Jones. (1995) The Organ Toxicity of Inhaled Anesthetics. Anesthesia & Analgesia 81:Supplement, pages 51S-66S.
Crossref
Graeme I. Murray, Valerie E. Taylor, Judith A. McKay, Richard J. Weaver, Stanley W. B. Ewen, William T. Melvin & M. Danny Burke. (2005) The immunohistochemical localization of drug‐metabolizing enzymes in prostate cancer. The Journal of Pathology 177:2, pages 147-152.
Crossref
EDWARD J. FRINKJR.JR.. (1995) Toxicologic potential of desflurane and sevoflurane. Acta Anaesthesiologica Scandinavica 39, pages 120-122.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.