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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 8
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Original Article

Hexobarbital metabolism: a new metabolic pathway to produce 1,5-dimethylbarbituric acid and cyclohexenone-glutathione adduct via 3′-oxohexobarbital

R. Takenoshita Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-01, Japan
,
T. Nakamura Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-01, Japan
&
S. Toki Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-01, Japan
Pages 925-934 | Received 03 Oct 1992, Accepted 02 Apr 1993, Published online: 23 Apr 2010

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L. NADELMANN*J. TJORNELUND, S. H. HANSEN, C. CORNETT, U. G. SIDELMANN, U. BRAUMANN, E. CHRISTENSEN & S. B. CHRISTENSEN. (1997) Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A. Xenobiotica 27:7, pages 667-680.
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Articles from other publishers (3)

Satoshi Endo, Toshiyuki Matsunaga, Atsuko Matsumoto, Yuki Arai, Satoshi Ohno, Ossama El-Kabbani, Kazuo Tajima, Yasuo Bunai, Shigeru Yamano, Akira Hara & Yukio Kitade. (2013) Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds. Biochemical Pharmacology 86:9, pages 1366-1375.
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Emmanuelle Guillot, Emuri Abe, Émilie Gautier, Djillali Annane & Jean-Claude Alvarez. (2009) Étude de la toxicocinétique de l’hexobarbital après intoxication aiguë polymédicamenteuse. Therapies 64:5, pages 325-330.
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Reiko TAKENOSHITA & Satoshi TOKI. (2004) New Aspects of Hexobarbital Metabolism: Stereoselective Metabolism, New Metabolic Pathway via GSH Conjugation, and 3-Hydroxyhexobarbital Dehydrogenasesヘキソバルビタール代謝研究の新たな展開:立体選択的代謝，グルタチオン抱合反応関与の新代謝経路並びに3-ハイドロキシヘキソバルビタール脱水素酵素. YAKUGAKU ZASSHI 124:12, pages 857-871.
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