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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 10
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Research Article

In vitro hepatic biotransformation of moclobemide (Ro 11-1163) in man and rat

B. Vallès F. Hoffmann-La Roche AG, Pharma Division, Preclinical Research, CH-4002, Basle, Switzerland
,
Ph. Coassolo F. Hoffmann-La Roche AG, Pharma Division, Preclinical Research, CH-4002, Basle, Switzerland
,
G. de Sousa INSERM, U278, Marseilles, France
,
C. Aubert INSERM, U278, Marseilles, France
&
R. Rahmani INSERM, U278, Marseilles, France
Pages 1101-1111 | Received 02 May 1993, Published online: 22 Sep 2008

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U. G. Sidelmann, C. Cornett, J. Tjørnelund & S. H. Hansen. (1996) A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rat using metronidazole as a model substance. Xenobiotica 26:7, pages 709-722.
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Articles from other publishers (6)

Daniel J. Watson, Lizahn Laing, Liezl Gibhard, Ho Ning Wong, Richard K. Haynes & Lubbe Wiesner. (2021) Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether. Antimicrobial Agents and Chemotherapy 65:8.
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Alina Plenis, Aleksandra Chmielewska, Lucyna Konieczna & Henryk Lamparczyk. (2007) A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies. Biomedical Chromatography 21:9, pages 958-966.
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R. Gasser, C. Funk, P. Matzinger, W. Klemisch & A. Viger-Chougnet. (1999) Use of Transgenic Cell Lines in Mechanistic Studies of Drug Metabolism. Toxicology in Vitro 13:4-5, pages 625-632.
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C. Delescluse, N. Ledirac, G. de Sousa, M. Pralavorio, D. Botta-Fridlund, Y. Letreut & R. Rahmani. (1997) Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types. Toxicology in Vitro 11:5, pages 443-450.
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P. Olinga, D.K.F. Meijer, M.J.H. Slooff & G.M.M. Groothuis. (1997) Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue. Toxicology in Vitro 12:1, pages 77-100.
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G. de Sousa, N. Florence, B. Vallès, P. Coassolo & R. Rahmani. (1995) Relationships betweenin vitro andin vivo biotransformation of drugs in humans and animals: pharmaco-toxicological consequences. Cell Biology and Toxicology 11:3-4, pages 147-153.
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