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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 11
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Research Article

Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man

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Pages 1255-1261 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Judit Bene, Botond Csiky, Istvan Wittmann, Endre Sulyok & Bela Melegh. (2012) Dramatic Decrease of Carnitine Esters after Interruption of Exogenous Carnitine Supply in Hemodialysis Patients. Renal Failure 34:5, pages 555-558.
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Judit Bene, Botond Csiky, Katalin Komlosi, Endre Sulyok & Bela Melegh. (2011) Dynamic adaptive changes of the serum carnitine esters during and after L-carnitine supplementation in patients with maintenance haemodialysis. Scandinavian Journal of Clinical and Laboratory Investigation 71:4, pages 280-286.
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Articles from other publishers (17)

Adel R. Moawad, Ali Salama, Magdy R. Badr & Mohamed Fathi. (2021) Beneficial Effects of L-Carnitine Supplementation during IVM of Canine Oocytes on Their Nuclear Maturation and Development In Vitro. Animals 11:2, pages 581.
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Yuanyuan Liang, Ton Yoisungnern, Yanni Huang & Rangsun Parnpai. (2020) Effects of L-carnitine on embryo development of vitrified swamp buffalo oocytes following in vitro fertilization. Livestock Science 232, pages 103933.
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Hatice Mutlu-Albayrak, Judit Bene, Mehmet Burhan Oflaz, Tijen Tanyalçın, Hüseyin Çaksen & Bela Melegh. (2015) Identification of SLC22A5 Gene Mutation in a Family with Carnitine Uptake Defect . Case Reports in Genetics 2015, pages 1-5.
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A. R. Moawad, B. Xu, S. L. Tan & T. Taketo. (2014) L-carnitine supplementation during vitrification of mouse germinal vesicle stage-oocytes and their subsequent in vitro maturation improves meiotic spindle configuration and mitochondrial distribution in metaphase II oocytes. Human Reproduction 29:10, pages 2256-2268.
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Botond Csiky, Judit Bene, Istvan Wittmann, Endre Sulyok & Bela Melegh. (2012) Effect of hemodialysis session on the dynamics of carnitine ester profile changes in l-carnitine pretreated end-stage renal disease patients. International Urology and Nephrology 45:3, pages 847-855.
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Ákos Várnagy, Judit Bene, Endre Sulyok, Gábor L Kovács, József Bódis & Béla Melegh. (2013) Acylcarnitine esters profiling of serum and follicular fluid in patients undergoing in vitro fertilization. Reproductive Biology and Endocrinology 11:1, pages 67.
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K. Komlósi, L. Magyari, G. C. Talián, É. Nemes, R. Káposzta, G. Mogyorósy, K. Méhes & B. Melegh. (2009) Plasma carnitine ester profile in homozygous and heterozygous OCTN2 deficiency. Journal of Inherited Metabolic Disease 32:S1, pages 15-19.
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Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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Béla Melegh, Judit Bene, Gábor Mogyorósy, Viktória Havasi, Katalin Komlósi, László Pajor, Éva Oláh, Gyula Kispál, Balázs Sumegi & Károly Méhes. (2004) Phenotypic manifestations of the OCTN2 V295X mutation: Sudden infant death and carnitine‐responsive cardiomyopathy in Roma families. American Journal of Medical Genetics Part A 131A:2, pages 121-126.
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Heather K. Nelson, Renee P. Lauber & Nancy F. Sheard. (2001) Effect of various levels of supplementation with sodium pivalate on tissue carnitine concentrations and urinary excretion of carnitine in the rat. The Journal of Nutritional Biochemistry 12:4, pages 242-250.
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Maria Pap, Gábor Kopcsányi, Loran L Bieber, Douglas A Gage & Béla Melegh. (1999) Cefetamet pivoxil treatment causes loss of carnitine reserves that can be prevented by exogenous carnitine administration. The Journal of Nutritional Biochemistry 10:11, pages 670-673.
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B. Melegh, L. Seress, T. Bedekovics, G. Kispál, B. Sümegi, K. Trombitás & K. Méhes. (1999) Muscle carnitine acetyltransferase and carnitine deficiency in a case of mitochondrial encephalomyopathy. Journal of Inherited Metabolic Disease 22:7, pages 827-838.
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Béla Melegh, Maria Pap, Gabriella Szekely, Douglas A. Gage, A.Dean Sherry & Loran L. Bieber. (1997) No replenishment of carnitine from trimethyllysine during pivalate-induced carnitine loss in humans. The Journal of Nutritional Biochemistry 8:3, pages 147-151.
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U. Zanelli, P. Puccini, D. Acerbi, P. Ventura & P. G. Gervasi. (1996) Induction of peroxisomal β-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney. Archives of Toxicology 70:3-4, pages 145-149.
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K MizojiriS FutaguchiR NorikuraY KatsuyamaT NagasakiT YoshimoriM Nakanishi. (1995) Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs. Antimicrobial Agents and Chemotherapy 39:7, pages 1445-1453.
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Tom L. Broderick, Denise DiDomenico, Dennis J. Paulson & Austin L. Shug. (1995) L -Propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency . Canadian Journal of Physiology and Pharmacology 73:4, pages 509-514.
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Bela Melegh, Maria Pap, Eva Morava, Denes Molnar, Maria Dani & Judit Kurucz. (1994) Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid. The Journal of Pediatrics 125:2, pages 317-321.
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