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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 12
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Research Article

Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in rat and cultured rat hepatocytes

R. W. Nims Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD, 21702, USA
,
P. R. Sinclair Veterans Administration Medical Center, White River Junction, VT, 05009, USA
,
J. F. Sinclair Veterans Administration Medical Center, White River Junction, VT, 05009, USA
,
K. H. Dragnev Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD, 21702, USA
,
C. R. Jones Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD, 21702, USA
,
D. W. Mellini Chemical Synthesis and Analysis Laboratory, PRI/DynCorp., NCI-FCRDC, Frederick, MD, 21702, USA
,
P. E. Thomas Department of Chemical Biology, College of Pharmacy, Rutgers University, Piscataway, NJ, 08855, USA
&
R. A. Lubet Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD, 21702, USA
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Pages 1411-1426 | Received 24 Jun 1993, Published online: 22 Sep 2008

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Yue-Ming Wang, Su Sien Ong, Sergio C Chai & Taosheng Chen. (2012) Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opinion on Drug Metabolism & Toxicology 8:7, pages 803-817.
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Larry G. Higgins & John D. Hayes. (2011) Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. Drug Metabolism Reviews 43:2, pages 92-137.
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Articles from other publishers (14)

Sarah Da Won Bae, Romario Nguyen, Liang Qiao & Jacob George. (2021) Role of the constitutive androstane receptor (CAR) in human liver cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:2, pages 188516.
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Brian G. Lake. (2018) Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. Toxicology Research 7:4, pages 697-717.
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L. Zhu, L. Lu, S. Wang, J. Wu, J. Shi, T. Yan, C. Xie, Q. Li, M. Hu & Z. Liu. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 297 329 .
Raphaëlle Luisier, Harri Lempiäinen, Nina Scherbichler, Albert Braeuning, Miriam Geissler, Valerie Dubost, Arne Müller, Nico Scheer, Salah-Dine Chibout, Hisanori Hara, Frank Picard, Diethilde Theil, Philippe Couttet, Antonio Vitobello, Olivier Grenet, Bettina Grasl-Kraupp, Heidrun Ellinger-Ziegelbauer, John P. Thomson, Richard R. Meehan, Clifford R. Elcombe, Colin J. Henderson, C. Roland Wolf, Michael Schwarz, Pierre Moulin, Rémi Terranova & Jonathan G. Moggs. (2014) Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors. Toxicological Sciences 139:2, pages 501-511.
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Akira Kubota, Afonso C.D. Bainy, Bruce R. Woodin, Jared V. Goldstone & John J. Stegeman. (2013) The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): Expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and Applied Pharmacology 272:1, pages 172-179.
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Sandra Halwachs, Carsten Kneuer & Walther Honscha. (2007) Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:6, pages 1671-1679.
Crossref
R. W. Nims, L. E. Beebe, W. E. UtermahlenJr.Jr., P. E. Thomas & R. A. Lubet. (2016) Induction of Hepatic Cytochromes P450 by Dietary 1,4-Bis[2–(3,5–dichloropyridyloxy)] benzene (TCPOBOP) in the B6C3F1 Mouse: Dose-Dependence and Pharmacodynamics. International Journal of Toxicology 18:2, pages 123-130.
Crossref
Tomonori Tateishi, Masako Asoh, Hironori Nakura, Minoru Watanabe, Masami Tanaka, Toshio Kumai & Shinichi Kobayashi. (1999) Carbamazepine induces multiple cytochrome P450 subfamilies in rats. Chemico-Biological Interactions 117:3, pages 257-268.
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Collins R Jones, Ronald A Lubet, John R Henneman & Raymond W Nims. (1998) Dose-response relationships for cytochrome P450 induction by phenobarbital in the cotton rat (Sigmodon hispidus). Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 121:1-3, pages 197-203.
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Edward T. Hellriegel, George A. Matwyshyn, Peiwen Fei, Konstantin H. Dragnev, Raymond W. Nims, Ronald A. Lubet & Ah-Ng Tony Kong. (1996) Regulation of gene expression of various Phase I and Phase II drug-metabolizing enzymes by tamoxifen in rat liver. Biochemical Pharmacology 52:10, pages 1561-1568.
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Matthew H. Slawson, Michael R. Franklin & David E. Moody. (1996) Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver. Toxicology Letters 85:1, pages 29-34.
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Konstantin H. Dragnev, Raymond W. Nims & Ronald A. Lubet. (1995) The chemopreventive agent diallyl sulfide. Biochemical Pharmacology 50:12, pages 2099-2104.
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Raymond W. Nims, Jaspreet S. Sidhu, Paul E. Thomas, Donna W. Mellini, Victor C. Nelson, Curtis J. Omiecinski & Ronald A. Lubet. (2006) Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5‐ethyl‐5‐phenylhydantoin in the male rat liver or in cultured rat hepatocytes. Journal of Biochemical Toxicology 9:6, pages 279-288.
Crossref
Raymond W. Nims, Ronald A. Lubet, Bhalchandra A. Diwan, Donna W. Mellini, William E. UtermahlenJr.Jr. & Paul E. Thomas. (2006) Hepatic cytochrome P450 2B induction by ethyl/ phenyl‐substituted congeners of phenobarbital in the B6C3F1 mouse. Journal of Biochemical Toxicology 9:5, pages 269-278.
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