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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 11
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Original Article

Metabolic disposition of tacrine in primary suspensions of rat hepatocyte and in single-pass perfused liver: in vitro/in vivo comparisons

M. Kukan Drug Metabolism Section, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI, 48105, USA
,
Š. Bezek Drug Metabolism Section, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI, 48105, USA
,
W. F. Pool Drug Metabolism Section, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI, 48105, USA
&
T. F. Woolf Drug Metabolism Section, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI, 48105, USA
Pages 1107-1117 | Received 29 Apr 1994, Published online: 27 Aug 2009

Citations (7)

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Read on this site (2)

J. Brian Houston & David J. Carlile. (1997) Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices. Drug Metabolism Reviews 29:4, pages 891-922.
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SK. Bezek, M. Kukan, W. F. Pool & T. F. Woolf. (1996) The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations. Xenobiotica 26:9, pages 935-946.
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Articles from other publishers (5)

Yin Cheong Wong, Shuai Qian & Zhong Zuo. (2014) Pharmacokinetic Comparison Between the Long-Term Anesthetized, Short-Term Anesthetized and Conscious Rat Models in Nasal Drug Delivery. Pharmaceutical Research 31:8, pages 2107-2123.
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Ren??ta Smrekov??Katar??na Vajdov??Mari??n Kukan, Olga Ulicn??Martina Lutterov??Ladislava Ws??lov??Jarom??r Horeck??. (2000) A RAPID, SIMPLE, AND COST-EFFECTIVE METHOD FOR SCREENING LIVER PRESERVATION SOLUTIONS IN THE RAT1. Transplantation 70:3, pages 430-436.
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Marián Kukan. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 425 442 .
Gregory L. Kedderis. (1997) Extrapolation of in vitro enzyme induction data to humans in vivo. Chemico-Biological Interactions 107:1-2, pages 109-121.
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O.Helen Chan, Michael W. Sinz & Barbra H. Stewart. (1997) Multiple-model evaluation of absorption of a tachykinin receptor antagonist. Advanced Drug Delivery Reviews 23:1-3, pages 121-131.
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