Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 1
52
Views
19
CrossRef citations to date
0
Altmetric
Original Article

Electron transfer in P450 mechanisms. Microsomal metabolism of cyclopropylbenzene and p-cyclopropylanisole

&
Pages 1-16 | Received 16 Sep 1993, Published online: 27 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Alexandre Gagnon, Martin Duplessis & Lee Fader. (2010) Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry. Organic Preparations and Procedures International 42:1, pages 1-69.
Read now
T. Lightfoot, S. W. Ellis, J. Mahling, M. J. Ackland, F. E. Blaney, G. J. Bijloo, M. J. De Groot, N. P. E. Vermeulen, G. M. Blackburn, M. S. Lennard & G. T. Tucker. (2000) Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling. Xenobiotica 30:3, pages 219-233.
Read now
P. N. Rizk & R. P. Hanzlik. (1995) Oxidative and non-oxidative metabolism of 4-iodoanisole by rat liver microsomes. Xenobiotica 25:2, pages 143-150.
Read now

Articles from other publishers (16)

R. S. Foti & D. K. Dalvie. (2016) Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics. Drug Metabolism and Disposition 44:8, pages 1229-1245.
Crossref
Alexander V. LyubimovRobert S. Foti, Dan A. Rock, Larry C. Wienkers & Jan L. Wahlstrom. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 68 .
Alexandre Gagnon, Martin Duplessis, Pamela Alsabeh & Francis Barabé. (2008) Palladium-Catalyzed Cross-Coupling Reaction of Tricyclopropylbismuth with Aryl Halides and Triflates. The Journal of Organic Chemistry 73:9, pages 3604-3607.
Crossref
Min-Jung Kang, Woon Ju Song, Ah-Rim Han, Young S. Choi, Ho G. Jang & Wonwoo Nam. (2007) Mechanistic Insight into the Aromatic Hydroxylation by High-Valent Iron(IV)-oxo Porphyrin π-Cation Radical Complexes. The Journal of Organic Chemistry 72:16, pages 6301-6304.
Crossref
Paul R. Ortiz de Montellano & James J. De Voss. 2005. Cytochrome P450. Cytochrome P450 183 245 .
Joseph E. Remias, Thomas A. Pavlosky & Ayusman Sen. (2003) Catalytic hydroxylation of benzene and cyclohexane using in situ generated hydrogen peroxide: new mechanistic insights and comparison with hydrogen peroxide added directly. Journal of Molecular Catalysis A: Chemical 203:1-2, pages 179-192.
Crossref
Sam P. de Visser & Sason Shaik. (2003) A Proton-Shuttle Mechanism Mediated by the Porphyrin in Benzene Hydroxylation by Cytochrome P450 Enzymes. Journal of the American Chemical Society 125:24, pages 7413-7424.
Crossref
Rheem A. Totah & Robert P. Hanzlik. (2001) Detection of Aminium Ion Intermediates:  N -Cyclopropyl versus N -Carboxymethyl Groups as Reporters . Journal of the American Chemical Society 123:41, pages 10107-10108.
Crossref
Christopher L. Shaffer, Martha D. Morton & Robert P. Hanzlik. (2000) Enzymatic N -Dealkylation of an N -Cyclopropylamine:  An Unusual Fate for the Cyclopropyl Group . Journal of the American Chemical Society 123:2, pages 349-350.
Crossref
Christian Audergon, Krishna R. Iyer, Jeffrey P. Jones, John F. Darbyshire & William F. Trager. (1998) Experimental and Theoretical Study of the Effect of Active-Site Constrained Substrate Motion on the Magnitude of the Observed Intramolecular Isotope Effect for the P450 101 Catalyzed Benzylic Hydroxylation of Isomeric Xylenes and 4,4‘-Dimethylbiphenyl. Journal of the American Chemical Society 121:1, pages 41-47.
Crossref
J.A.G. AgúndezF. J. Jiménez-JiménezA. LuengoJ. A. MolinaM. Ortí-ParejaA. VázquezF. RamosJ. DuarteF. CoriaJ. M. LaderoJ. C. Alvarez-CermeñoJ. Benítez. (1998) Slow allotypic variants of the NAT2 gene and susceptibility to early-onset Parkinson's disease . Neurology 51:6, pages 1587-1592.
Crossref
Zhiyang Zhao, Stéphane Mabic, Simon Kuttab, Christelle Franot, Kay Castagnoli & Neal CastagnoliJr.Jr.. (1998) Rat liver microsomal enzyme catalyzed oxidation of 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine. Bioorganic & Medicinal Chemistry 6:12, pages 2531-2539.
Crossref
Hao Chen, Marcel J. de Groot, Nico P. E. Vermeulen & Robert P. Hanzlik. (1997) Oxidative N-Dealkylation of p -Cyclopropyl- N,N -dimethylaniline. A Substituent Effect on a Radical-Clock Reaction Rationalized by Ab Initio Calculations on Radical Cation Intermediates . The Journal of Organic Chemistry 62:23, pages 8227-8230.
Crossref
Michail A. Alterman, Chandra S. Chaurasia, Ping Lu, James P. Hardwick & Robert P. Hanzlik. (1995) Fatty acid discrimination and ω-hydroxylation by cytochrome P450 4A1 and a cytochrome P4504A1/NADPH-P450 reductase fusion protein. Archives of Biochemistry and Biophysics 320:2, pages 289-296.
Crossref
B.Kevin Park, Munir Pirmohamed & Neil R. Kitteringham. (1995) The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacology & Therapeutics 68:3, pages 385-424.
Crossref
Paul R. Ortiz de Montellano. 1995. Cytochrome P450. Cytochrome P450 245 303 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.