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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 3
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Original Article

7-Ethoxycoumarin O-deethylase kinetics in isolated rat, dog and human hepatocyte suspensions

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Pages 231-241 | Received 05 Oct 1993, Published online: 27 Aug 2009

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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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JAN G. HENGSTLER, D. UTESCH, P. STEINBERG, K. L. PLATT, B. DIENER, M. RINGEL, N. SWALES, T. FISCHER, K. BIEFANG, M. GERL, T. BÖTTGER & F. OESCH. (2000) CRYOPRESERVED PRIMARY HEPATOCYTES AS A CONSTANTLY AVAILABLE IN VITRO MODEL FOR THE EVALUATION OF HUMAN AND ANIMAL DRUG METABOLISM AND ENZYME INDUCTION*. Drug Metabolism Reviews 32:1, pages 81-118.
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D. M. Cross, J. A. Bell & K. Wilson. (1995) Kinetics of ranitidine metabolism in dog and rat isolated hepatocytes. Xenobiotica 25:4, pages 367-375.
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Articles from other publishers (17)

Ziru Dai, Yue Wu, Yuan Xiong, Jingjing Wu, Min Wang, Xiao Sun, Xinxin Ding, Ling Yang, Xiaobo Sun & Guangbo Ge. (2023) CYP1A inhibitors: Recent progress, current challenges, and future perspectives. Medicinal Research Reviews 44:1, pages 169-234.
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Kyoungju ChoiWilliam P. PfundMelvin E. AndersenRussell S. ThomasHarvey J. ClewellEdward L. LeCluyse. (2014) Development of 3D Dynamic Flow Model of Human Liver and Its Application to Prediction of Metabolic Clearance of 7-Ethoxycoumarin. Tissue Engineering Part C: Methods 20:8, pages 641-651.
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Mostafa Kabiri. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 1329 1351 .
Leandro Augusto Calixto, Anderson Rodrigo Moraes de Oliveira, Valqu?ria Aparecida Polisel Jabor & Pierina Sueli Bonato. (2011) In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction. European Journal of Drug Metabolism and Pharmacokinetics 36:3, pages 159-166.
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Paul M. van Midwoud, Elisabeth Verpoorte & Geny M. M. Groothuis. (2011) Microfluidic devices for in vitro studies on liver drug metabolism and toxicity. Integrative Biology 3:5, pages 509.
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D. Behera, A. Damre, A. Varghese & V. Addepalli. (2008) In Vitro Evaluation of Hepatic and Extra-hepatic Metabolism of Coumarins Using Rat Subcellular Fractions: Correlation of In Vitro Clearance with In Vivo Data. Drug Metabolism and Drug Interactions 23:3-4.
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Samuele Pedraglio, Marco Giulio Rozio, Paola Misiano, Veronica Reali, Giulio Dondio & Chiara Bigogno. (2007) New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis 44:3, pages 665-673.
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Inge A. M. de Graaf, Ruben de Kanter, Marina H. de Jager, Raquel Camacho, Elise Langenkamp, Esther G. van de Kerkhof & Geny M. M. Groothuis. (2006) EMPIRICAL VALIDATION OF A RAT IN VITRO ORGAN SLICE MODEL AS A TOOL FOR IN VIVO CLEARANCE PREDICTION. Drug Metabolism and Disposition 34:4, pages 591-599.
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Anja Kristina Froehlich, Ulrich Girreser & Bernd Clement. (2005) METABOLISM OF N -HYDROXYGUANIDINES ( N -HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES . Drug Metabolism and Disposition 33:10, pages 1532-1537.
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Daniel R. Mudra & Andrew Parkinson. (2001) Preparation of Hepatocytes. Current Protocols in Toxicology 8:1.
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E Tanaka, A Ishikawa & T Horie. (2016) In vivo and in vitro trimethadione oxidation activity of the liver from various animal species including mouse, hamster, rat, rabbit, dog, monkey and human. Human & Experimental Toxicology 18:1, pages 12-16.
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Bjarte Mortensen & Odd G. Nilsen. (2009) Allometric Species Comparison of Toluene and n –Hexane Metabolism: Prediction of Hepatic Clearance in Man from Experiments with Rodent Liver S9 in a Head Space Vial Equilibration System . Pharmacology & Toxicology 82:4, pages 183-188.
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M. Teresa Donato, José V. Castell & Maria José Gómez-Lechón. (2020) The Coumarin 7-Hydroxylation Microassay in Living Hepatic Cells in Culture. Alternatives to Laboratory Animals 26:2, pages 213-223.
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Peter Olinga, Marjolijn Merema, Maarten J.H. Slooff, Dirk K.F. Meijer & Geny M.M. Groothuis. (1997) Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes. Journal of Hepatology 27:4, pages 738-743.
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A Kern, A Bader, R Pichlmayr & K.-F Sewing. (1997) Drug metabolism in hepatocyte sandwich cultures of rats and humans. Biochemical Pharmacology 54:7, pages 761-772.
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Bjarte Mortensen, Torbjørn Løkken, Kolbjørn Zahlsen & Odd G. Nilsen. (2009) Comparison and in vivo Relevance of Two Different in vitro Head Space Metabolic Systems: Liver S9 and Liver Slices . Pharmacology & Toxicology 81:1, pages 35-41.
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Hiroshi Yamazaki, Kiyoshi Inoue, Mayumi Mimura, Yoshimitsu Oda, F.Peter Guengerich & Tsutomu Shimada. (1996) 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes. Biochemical Pharmacology 51:3, pages 313-319.
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