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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 3
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Original Article

Bromobenzene detoxification in the human liver-derived HepG2 cell line

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Pages 265-279 | Received 08 Jun 1993, Published online: 27 Aug 2009

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Fu-Chuo Peng, Chaing Hsin-Hui, Tang Sheng-Hui, Chen Pei-Chun & Lu Shao-Chun. (2004) Nadph-Cytochrome P-450 Reductase is Involved in Flunitrazepam Reductive Metabolism in Hep G2 and Hep 3b Cells. Journal of Toxicology and Environmental Health, Part A 67:2, pages 109-124.
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J. Wu, K. Karlsson & Å. Danielsson. (1996) Protective Effects of Trolox C, Vitamin C, and Catalase on Bromobenzene-Induced Damage to Rat Hepatocytes. Scandinavian Journal of Gastroenterology 31:8, pages 797-803.
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S. J. Duthie, W. T. Melvin & M. D. Burke. (1995) Drug toxicity mechanisms in human hepatoma HepG2 cells: cyclosporin A and tamoxifen. Xenobiotica 25:10, pages 1151-1164.
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Hamdoon A. Mohammed, Hussein M. Eldeeb, Riaz A. Khan, Mohsen S. Al-Omar, Salman A. A. Mohammed, Mohammed S. M. Sajid, Mohamed S. A. Aly, Adel M. Ahmad, Ahmed A. H. Abdellatif, Safaa Yehia Eid & Mahmoud Zaki El-Readi. (2021) Sage, Salvia officinalis L., Constituents, Hepatoprotective Activity, and Cytotoxicity Evaluations of the Essential Oils Obtained from Fresh and Differently Timed Dried Herbs: A Comparative Analysis. Molecules 26:19, pages 5757.
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Atiruj Theppawong, Tim Van de Walle, Charlotte Grootaert, Kristof Van Hecke, Nathalie Catry, Tom Desmet, John Van Camp & Matthias D'hooghe. (2019) Synthesis of Non‐Symmetrical Nitrogen‐Containing Curcuminoids in the Pursuit of New Anticancer Candidates. ChemistryOpen 8:2, pages 236-247.
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Dahryn TrivediDrDr & Snehasis JanaDrDr. (2018) Assessment of Biofield Energy Treatment on Liver Health Using Hepatocellular Carcinoma Cell Line (HepG2). Journal of Gastrointestinal Disorders and Liver function 4:1, pages 17-23.
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Atiruj Theppawong, Tim Van de Walle, Charlotte Grootaert, Margot Bultinck, Tom Desmet, John Van Camp & Matthias D'hooghe. (2018) Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines. ChemistryOpen 7:5, pages 381-392.
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Liliana Torres González, Noemí Waksman Minsky, Linda Elsa Muñoz Espinosa, Ricardo Salazar Aranda, Jonathan Pérez Meseguer & Paula Cordero Pérez. (2017) In vitro assessment of hepatoprotective agents against damage induced by acetaminophen and CCl4. BMC Complementary and Alternative Medicine 17:1.
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Heba A. S. El-Nashar, Omayma A. Eldahshan, Omama E. Elshawi & Abdel Nasser B. Singab. (2017) Phytochemical Investigation, Antitumor Activity, and Hepatoprotective Effects of Acrocarpus fraxinifolius Leaf Extract . Drug Development Research 78:5, pages 210-226.
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S. Mathan Kumar & Aparajita Dey. (2014) Regulation of Glutathione in Health and Disease with Special Emphasis on Chronic Alcoholism and Hyperglycaemia Mediated Liver Injury: A Brief Perspective. Springer Science Reviews 2:1-2, pages 1-13.
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R Krithika, RJ Verma & PS Shrivastav. (2012) Antioxidative and cytoprotective effects of andrographolide against CCl 4 -induced hepatotoxicity in HepG2 cells . Human & Experimental Toxicology 32:5, pages 530-543.
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M Ira Thabrew, Robin D Hughes & Ian G McFarlane. (1997) Screening of Hepatoprotective Plant Components using a HepG2 Cell Cytotoxicity Assay. Journal of Pharmacy and Pharmacology 49:11, pages 1132-1135.
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Rajesh Krithika, Ramasamy Mohankumar, Ramtej J. Verma, Pranav S. Shrivastav, Illiyas L. Mohamad, Palani Gunasekaran & Srinivasan Narasimhan. (2009) Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. Chemico-Biological Interactions 181:3, pages 351-358.
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Jorge L. Zurita, Ángeles Jos, Ana del Peso, Manuel Salguero, Miguel López-Artíguez & Guillermo Repetto. (2007) Ecotoxicological assessment of bromobenzene using a test battery with five model systems. Food and Chemical Toxicology 45:4, pages 575-584.
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P.F. Dehn, S. Allen-Mocherie, J. Karek & A. Thenappan. (2005) Organochlorine insecticides: impacts on human HepG2 cytochrome P4501A, 2B activities and glutathione levels. Toxicology in Vitro 19:2, pages 261-273.
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P. F. DEHN, C. M. WHITE, D. E. CONNERS, G. SHIPKEY & T. A. CUMBO. (2004) CHARACTERIZATION OF THE HUMAN HEPATOCELLULAR CARCINOMA (HEPG2) CELL LINE AS AN IN VITRO MODEL FOR CADMIUM TOXICITY STUDIES. In Vitro Cellular & Developmental Biology - Animal 40:5, pages 172.
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Joseph W. DePierre. 2003. Organic Bromine and Iodine Compounds. Organic Bromine and Iodine Compounds 205 251 .
Simon G.W Wong, Jeffrey W Card & William J Racz. (2000) The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity. Toxicology Letters 116:3, pages 171-181.
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Marina Camatini, Patrizia Bonfanti, Anita Colombo, Chiara Urani & Silvia Crippa. (1999) Cellular and Molecular Targets of Benzo[a]pyrene and Metal Toxicity in Xenopus laevis Embryos and in Hep G2 Cells . Alternatives to Laboratory Animals 27:3, pages 325-337.
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Yuan-Soon Ho, Pei-Wen Tsai, Cheng-Fei Yu, Hsu-Ling Liu, Rong-Jane Chen & Jen-Kun Lin. (1998) Ketoconazole-Induced Apoptosis through P53-Dependent Pathway in Human Colorectal and Hepatocellular Carcinoma Cell Lines. Toxicology and Applied Pharmacology 153:1, pages 39-47.
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E Hernández, M.C Gutiérrez-Ruiz & G Garcı́a Vargas. (1998) Effect of acute lead treatment on coproporphyrinogen oxidase activity in HepG2 cells. Toxicology 126:3, pages 163-171.
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Jian WU, Kurt Karlsson & Åke Danielsson. (1997) Effects of vitamins E, C and catalase on bromobenzene- and hydrogen peroxide-induced intracellular oxidation and DNA single-strand breakage in Hep G2 cells. Journal of Hepatology 26:3, pages 669-677.
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Laurence Nicod, Catherine Viollon, Any Regnier, Alain Jacqueson & Lysiane Richert. (2017) Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells. Human & Experimental Toxicology 16:1, pages 28-34.
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Susan J Duthie & Andrew R Collins. (1997) The Influence of Cell Growth, Detoxifying Enzymes and DNA Repair on Hydrogen Peroxide-Mediated DNA Damage (Measured Using the Comet Assay) in Human Cells. Free Radical Biology and Medicine 22:4, pages 717-724.
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K K Grewal, E Rafeiro & W J Racz. (1996) Bromobenzene and furosemide hepatotoxicity: alterations in glutathione, protein thiols, and calcium. Canadian Journal of Physiology and Pharmacology 74:3, pages 257-264.
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Johanna Fink‐Gremmels, Andrea Jahn & Maarten J. Blom. (2006) Toxicity and metabolism of ochratoxin A. Natural Toxins 3:4, pages 214-220.
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