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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 5
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Research Article

In vitro metabolism of theophylline by rat and human liver tissue

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Pages 389-399 | Received 19 Jan 1994, Published online: 22 Sep 2008

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Vidya Perera, Annette S Gross, Thomas M Polasek, Yan Qin, Gauri Rao, Alan Forrest, Junzhe Xu & Andrew J McLachlan. (2013) Considering CYP1A2 phenotype and genotype for optimizing the dose of olanzapine in the management of schizophrenia. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1115-1137.
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A. Santi, P. Anfossi, N. G. Coldham, F. Capolongo, M. J. Sauer & C. Montesissa. (2002) Biotransformation of benzydamine by microsomes and precision-cut slices prepared from cattle liver. Xenobiotica 32:1, pages 73-86.
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Articles from other publishers (14)

Meixia Chen. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 5 .
Yune-Fang UengTung-Hu TsaiMing-Jaw DonRuei-Ming ChenTa-Liang Chen. (2005) Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa , in rats . Journal of Pharmacy and Pharmacology 57:2, pages 227-232.
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Yune-Fang Ueng, Ching-Chin Tsai, Wei-Sheng Lo & Chul-Ho Yun. (2010) Induction of Hepatic Cytochrome P450s by the Herbal Medicine Sophora flavescens Extract in Rats: Impact on the Elimination of Theophylline. Drug Metabolism and Pharmacokinetics 25:6, pages 560-567.
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Sandrine Derkenne, Christine P. Curran, Howard G. Shertzer, Timothy P. Dalton, Nadine Dragin & Daniel W. Nebert. (2005) Theophylline pharmacokinetics: comparison of Cyp1a1(−/−) and Cyp1a2(−/−) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. Pharmacogenetics and Genomics 15:7, pages 503-511.
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Makiko Kizawa, Etsuko Miyamoto, Shuka Aono, Junichi Kawakami & Isao Adachi. (2005) Inhibition of Theophylline Metabolism by Suplatast and Its Metabolites in Rats. Biological and Pharmaceutical Bulletin 28:6, pages 1061-1065.
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O. Kretz, C. Guenat, P. Beilstein & G. Gross. (2002) Coincubation of tissue slices, a new way to study metabolic cooperation between organs: Hepatorenal cooperation in the biotransformation of CGP 47 969 A. Journal of Pharmacological and Toxicological Methods 48:2, pages 119-126.
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K Walton, J.L Dorne & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates. Food and Chemical Toxicology 39:7, pages 667-680.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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Sean Ekins, Jukka Maenpää & Steven Wrighton. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 363 399 .
J.P Cravedi, E Perdu-Durand & A Paris. (1998) Cytochrome P450-dependent metabolic pathways and glucuronidation in trout liver slices. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 121:1-3, pages 267-275.
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James L. Ferrero & Klaus Brendel. 1997. 131 169 .
P. Olinga, D.K.F. Meijer, M.J.H. Slooff & G.M.M. Groothuis. (1997) Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue. Toxicology in Vitro 12:1, pages 77-100.
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D. Müller, R. Glöckner & M. Rost. (1996) Monooxygenation, cytochrome P4501A1 and P4501A1-mRNA in rat liver slices exposed to beta-naphthoflavone and dexamethasone in vitro. Experimental and Toxicologic Pathology 48:5, pages 433-438.
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R. Glöckner & D. Müller. (1995) Ethoxycoumarin O-deethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro. Experimental and Toxicologic Pathology 47:4, pages 319-324.
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