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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 5
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Research Article

Hydrolysis, absorption and metabolism of di(2-ethylhexyl) terephthalate in the rat

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Pages 441-450 | Received 23 Sep 1993, Published online: 22 Sep 2008

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Frederik Lessmann, Daniel Bury, Tobias Weiss, Heiko Hayen, Thomas Brüning & Holger M. Koch. (2018) De-novo identification of specific exposure biomarkers of the alternative plasticizer di(2-ethylhexyl) terephthalate (DEHTP) after low oral dosage to male volunteers by HPLC-Q-Orbitrap-MS. Biomarkers 23:2, pages 196-206.
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Gwendolyn L. Ball, Clifton J. McLellan & Virunya S. Bhat. (2012) Toxicological review and oral risk assessment of terephthalic acid (TPA) and its esters: A category approach. Critical Reviews in Toxicology 42:1, pages 28-67.
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Sergiu Adrian Chicu. (2023) New insights into binary mixture toxicology: 2. Effects of reactive oxygen species generated by some carboxylic diesters on marine and freshwater organisms (VIII). Computational Toxicology 27, pages 100283.
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Helmut Greim. 2003. Patty's Toxicology. Patty's Toxicology 1 74 .
Nicolas Kambia, Isabelle Séverin, Amaury Farce, Laurence Dahbi, Thierry Dine, Emmanuel Moreau, Valérie Sautou & Marie-Christine Chagnon. (2021) Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies. Metabolites 11:2, pages 94.
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Sergiu Adrian Chicu. (2019) Structure–activity relationship (SAR) study of some aliphatic and aromatics carboxyl– and α–amino–C–phosphonates congeneric esters and Schiff derivatives using a developed Köln–model (Hydractinia echinata Toxicity Screening Test System. VI.). Computational Toxicology 12, pages 100099.
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Nicolas K. Kambia, Isabelle Séverin, Amaury Farce, Emmanuel Moreau, Laurence Dahbi, Claire Duval, Thierry Dine, Valérie Sautou & Marie‐Christine Chagnon. (2019) In vitro and in silico hormonal activity studies of di‐(2‐ethylhexyl)terephthalate, a di‐(2‐ethylhexyl)phthalate substitute used in medical devices, and its metabolites. Journal of Applied Toxicology 39:7, pages 1043-1056.
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Christina Christia, Giulia Poma, Stuart Harrad, Cynthia A. de Wit, Ylva Sjostrom, Pim Leonards, Marja Lamoree & Adrian Covaci. (2019) Occurrence of legacy and alternative plasticizers in indoor dust from various EU countries and implications for human exposure via dust ingestion and dermal absorption. Environmental Research 171, pages 204-212.
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Brian J. Hughes, Kevin Cox & Virunya Bhat. (2018) Derivation of an oral reference dose (RfD) for di 2-ethylhexyl cyclohexan-1,4-dicarboxylate (DEHCH), an alternative to phthalate plasticizers. Regulatory Toxicology and Pharmacology 92, pages 128-137.
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Stefanie Baldofski, Carsten Jörg Canitz, Leif-Alexander Garbe & Rudolf J. Schneider. (2018) Studies on the development of antibodies for the highly hydrophobic plasticizers DINCH and DEHT. Analytical Biochemistry 543, pages 90-96.
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Cristiano Grings Herbert, Luiz Rogério De Andrade Lima & Cristiane Gonçalves. Alternative to Phthalate Plasticizer for PVC/NBR Formulation Used in Automotive Fuel System with Biodiesel. Alternative to Phthalate Plasticizer for PVC/NBR Formulation Used in Automotive Fuel System with Biodiesel.
Frederik Lessmann, André Schütze, Tobias Weiss, Angelika Langsch, Rainer Otter, Thomas Brüning & Holger M. Koch. (2016) Metabolism and urinary excretion kinetics of di(2-ethylhexyl) terephthalate (DEHTP) in three male volunteers after oral dosage. Archives of Toxicology 90:7, pages 1659-1667.
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Frederik Lessmann, André Schütze, Tobias Weiss, Thomas Brüning & Holger M. Koch. (2016) Determination of metabolites of di(2-ethylhexyl) terephthalate (DEHTP) in human urine by HPLC-MS/MS with on-line clean-up. Journal of Chromatography B 1011, pages 196-203.
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Thuy T. Bui, Georgios Giovanoulis, Anna Palm Cousins, Jörgen Magnér, Ian T. Cousins & Cynthia A. de Wit. (2016) Human exposure, hazard and risk of alternative plasticizers to phthalate esters. Science of The Total Environment 541, pages 451-467.
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H. Al Salloum, J. Saunier, C. Aymes-Chodur, H. Barakat & N. Yagoubi. (2015) Impact of the nature and concentration of plasticizers on the ability of PVC to sorb drug. International Journal of Pharmaceutics 496:2, pages 664-675.
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Manori J. Silva, Ella Samandar, Antonia M. Calafat & Xiaoyun Ye. (2015) Identification of di-2-ethylhexyl terephthalate (DEHTP) metabolites using human liver microsomes for biomonitoring applications. Toxicology in Vitro 29:4, pages 716-721.
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Thomas G. Osimitz, William J. Welsh, Ni Ai & Colleen Toole. (2015) Polyester monomers lack ability to bind and activate both androgenic and estrogenic receptors as determined by In Vitro and In Silico methods. Food and Chemical Toxicology 75, pages 128-138.
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L. Bernard, B. Décaudin, M. Lecoeur, D. Richard, D. Bourdeaux, R. Cueff & V. Sautou. (2014) Analytical methods for the determination of DEHP plasticizer alternatives present in medical devices: A review. Talanta 129, pages 39-54.
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Federica Chiellini, Marcella Ferri, Andrea Morelli, Lucia Dipaola & Giuseppe Latini. (2013) Perspectives on alternatives to phthalate plasticized poly(vinyl chloride) in medical devices applications. Progress in Polymer Science 38:7, pages 1067-1088.
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Cecilia Springer, Edward Dere, Susan J. Hall, Elizabeth V. McDonnell, Simon C. Roberts, Craig M. Butt, Heather M. Stapleton, Deborah J. Watkins, Michael D. McClean, Thomas F. Webster, Jennifer J. Schlezinger & Kim Boekelheide. (2012) Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a Novel Brominated Flame Retardant Present in Indoor Dust. Environmental Health Perspectives 120:12, pages 1711-1719.
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Raymond M. David, Ammie N. Bachman, John H. Butala, John T. Piper & Catherine J. Shelp. 2003. Patty's Toxicology. Patty's Toxicology 147 352 .
U. Wirnitzer, U. Rickenbacher, A. Katerkamp & A. Schachtrupp. (2011) Systemic toxicity of di-2-ethylhexyl terephthalate (DEHT) in rodents following four weeks of intravenous exposure. Toxicology Letters 205:1, pages 8-14.
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James A. Deyo. (2008) Carcinogenicity and chronic toxicity of di-2-ethylhexyl terephthalate (DEHT) following a 2-year dietary exposure in Fischer 344 rats. Food and Chemical Toxicology 46:3, pages 990-1005.
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S. Barnabé, I. Beauchesne, D.G. Cooper & J.A. Nicell. (2008) Plasticizers and their degradation products in the process streams of a large urban physicochemical sewage treatment plant. Water Research 42:1-2, pages 153-162.
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A. Dalman, H. Eimani, S.K. Ashtiani, M.R. Valojerdi, P. Eftekhari‐Yazdi, A. Shahverdi & H. Sepehri. (2009) Effect of mono‐(2‐ethylhexyl) phthalate (MEHP) on resumption of meiosis, in vitro maturation and embryo development of immature mouse oocytes . BioFactors 33:2, pages 149-155.
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Willem D. Faber, James A. Deyo, Donald G. Stump & Karen Ruble. (2007) Two-generation reproduction study of di-2-ethylhexyl terephthalate in Crl:CD rats. Birth Defects Research Part B: Developmental and Reproductive Toxicology 80:2, pages 69-81.
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James Gartshore, David G. Cooper & Jim A. Nicell. (2009) Biodegradation of plasticizers by Rhodotorula rubra . Environmental Toxicology and Chemistry 22:6, pages 1244-1251.
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Raymond M. David, Richard H. McKee, John H. Butala, Robert A. Barter & Martin Kayser. 2003. Patty's Toxicology. Patty's Toxicology.
E.D. Barber & D.C. Topping. (1995) Subchronic 90-day oral toxicology of Di(2-ethylhexyl) terephthalate in the rat. Food and Chemical Toxicology 33:11, pages 971-978.
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