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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 6
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Research Article

Irreversible binding of tolmetin to macromolecules via its glucuronide: Binding to blood constituents, tissue homogenates and subcellular fractions in vitro

J. C. Ojingwa Department of Pharmacy, University of California, San Francisco, CA, 94143-0446, USA
,
H. Spahn-Langguth Department of Pharmacy, University of California, San Francisco, CA, 94143-0446, USA
&
L. Z. Benet Department of Pharmacy, University of California, San Francisco, CA, 94143-0446, USA
Pages 495-506 | Received 01 Mar 1993, Published online: 22 Sep 2008

Citations (12)

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Read on this site (1)

Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Articles from other publishers (11)

Atsushi Iwamura, Miki Nakajima, Shingo Oda & Tsuyoshi Yokoi. (2017) Toxicological potential of acyl glucuronides and its assessment. Drug Metabolism and Pharmacokinetics 32:1, pages 2-11.
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Howard Horng, Hilde Spahn-Langguth & Leslie Z. Benet. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 35 70 .
Myriam Saade, Jacques Magdalou, Naim Ouaini & Helene Greige‐Gerges. (2009) Stability of cucurbitacin E in human plasma: chemical hydrolysis and role of plasma esterases. Biopharmaceutics & Drug Disposition 30:7, pages 389-397.
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Benedetta C. Sallustio. 2008. 57 86 .
Hilde Spahn-Langguth, Chunze Li & Leslie Benet. 2007. Drug-Induced Liver Disease, Second Edition. Drug-Induced Liver Disease, Second Edition 125 157 .
Maria Shipkova, Victor William Armstrong, Michael Oellerich & Eberhard Wieland. (2003) Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications. Therapeutic Drug Monitoring 25:1, pages 1-16.
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Graeme R Cannell, Mark J Bailey & Ronald G Dickinson. (2002) Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro. Life Sciences 71:22, pages 2633-2643.
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Sebastien Bolze, Norbert Bromet, Croisine Gay-Feutry, Frederic Massiere, Roselyne Boulieu & Thierry Hulot. (2002) Development of an in Vitro Screening Model for the Biosynthesis of Acyl Glucuronide Metabolites and the Assessment of Their Reactivity toward Human Serum Albumin. Drug Metabolism and Disposition 30:4, pages 404-413.
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Nadège Terrier, Etienne Benoit, Claire Senay, Françoise Lapicque, Anna Radominska-Pandya, Jacques Magdalou & Sylvie Fournel-Gigleux. (1999) Human and Rat Liver UDP-Glucuronosyltransferases Are Targets of Ketoprofen Acylglucuronide. Molecular Pharmacology 56:1, pages 226-234.
Crossref
Brian Burchell. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 153 173 .
Hildegard Spahn-Langguth, Monika Dahms & Andreas Hermening. 1996. Biological Reactive Intermediates V. Biological Reactive Intermediates V 313 328 .

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