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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 6
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Research Article

Characterization of the inhibition of P4501A2 by furafylline

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Pages 517-526 | Received 19 Nov 1993, Published online: 22 Sep 2008

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Shu-Feng Zhou, Bo Wang, Li-Ping Yang & Jun-Ping Liu. (2010) Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metabolism Reviews 42:2, pages 268-354.
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William W. Johnson. (2008) Cytochrome P450 Inactivation by Pharmaceuticals and Phytochemicals: Therapeutic Relevance. Drug Metabolism Reviews 40:1, pages 101-147.
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A. Nakashima, H. Kawashita, N. Masuda, C. Saxer, M. Niina, Y. Nagae & K. Iwasaki. (2005) Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes. Xenobiotica 35:6, pages 589-602.
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D. F. V. Lewis, B. G. Lake, M. Dickins, Y.-F. Ueng & P. S. Goldfarb. (2003) Homology modelling of human CYP1A2 based on the CYP2C5 crystallographic template structure. Xenobiotica 33:3, pages 239-254.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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V. Subrahmanyam, A. B. Renwick, D. G. Walters, R. J. Price, A. P. Tonelli & B. G. Lake. (2002) Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms. Xenobiotica 32:6, pages 521-534.
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M. S. Ching, C. L. Blake, N. A. Malek, P. W. Angus & H. Ghabrial. (2001) Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine. Xenobiotica 31:11, pages 757-767.
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A. B. Renwick, D. Surry, R. J. Price, B. G. Lake & D. C. Evans. (2000) Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms. Xenobiotica 30:10, pages 955-969.
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N. Ishiguro, C. Senda, W. Kishimoto, K. Sakai, Y. Funae, T. Igarashi. (2000) Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes. Xenobiotica 30:1, pages 71-80.
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R. AZUMA, M. KOMURO, B. H. KORSCH, J. C. ANDRE, O. ONNAGAWA, S. R. BLACK & J. M. MATHEWS. (1999) Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease. Xenobiotica 29:7, pages 747-762.
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A. B. RENWICK, H. MISTRY, S. E. BALL, D. G. WALTERS, J. KAO & B. G. LAKE. (1998) Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms. Xenobiotica 28:4, pages 337-348.
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O. PELKONEN, J. MÄEENPÄEÄ, P. TAAVITSAINEN, A. RAUTIO & H. RAUNIO. (1998) Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28:12, pages 1203-1253.
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S. E. CLARKE. (1998) In vitro assessment of human cytochrome P450. Xenobiotica 28:12, pages 1167-1202.
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D. A. SMITH, S. M. ABEL, R. HYLAND & B. C. JONES. (1998) Human cytochrome P450s: selectivity and measurement in vivo. Xenobiotica 28:12, pages 1095-1128.
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S. J. Baldwin, J. C. Bloomer, G. J. Smith, A. D. Ayrton, S. E. Clarke & R. J. Chenery. (1995) Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica 25:3, pages 261-270.
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J. C. Bloomer, S. E. Clarke & R. J. Chenery. (1995) Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine. Xenobiotica 25:9, pages 917-927.
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P.R Tiller, A.P Land, I Jardine, D.M Murphy, R Sozio, A Ayrton & W.H Schaefer. (1998) Application of liquid chromatography–mass spectrometryn analyses to the characterization of novel glyburide metabolites formed in vitro. Journal of Chromatography A 794:1-2, pages 15-25.
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Michael Murray. (2007) DRUG‐MEDIATED INACTIVATION OF CYTOCHROME P450. Clinical and Experimental Pharmacology and Physiology 24:7, pages 465-470.
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Aleksandra Pastrakuljic, Bing K. Tang, Eve A. Roberts & Wemer Kalow. (1997) Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole. Biochemical Pharmacology 53:4, pages 531-538.
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H.Kim Crewe, S.Wynne Ellis, Martin S. Lennard & Geoffrey T. Tucker. (1997) Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes. Biochemical Pharmacology 53:2, pages 171-178.
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Thomas G. Schulz, Diether Neubert, Donald S. Davies & Robert J. Edwards. (1996) Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus). Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1298:1, pages 131-140.
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Alan R. Boobis, Nigel J. Gooderham, Robert J. Edwards, Stephen Murray, Anthony M. Lynch, Masoud Yadollahi-Farsani & Donald S. Davies. 1996. Toxicology - From Cells to Man. Toxicology - From Cells to Man 286 302 .
Y. Amet, F. Berthou, S. Baird, Y. Dreano, J.P. Bail & J.F. Menez. (1995) Validation of the (ω-l)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. Biochemical Pharmacology 50:11, pages 1775-1782.
Crossref
Charles L. Crespi. 1995. Advances in Drug Research Volume 26. Advances in Drug Research Volume 26 179 235 .
Paul R. Ortiz de Montellano & Maria Almira Correia. 1995. Cytochrome P450. Cytochrome P450 305 364 .
JC Bloomer, SJ Baldwin, GJ Smith, AD Ayrton, SE Clarke & RJ Chenery. (2012) Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.. British Journal of Clinical Pharmacology 38:6, pages 557-566.
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