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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 6
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Research Article

Dextromethorphan metabolism in rat: Interstrain differences and the fate of individually administered oxidative metabolites

F. Bochner Department of Clinical and Experimental Pharmacology and Clinical Pharmacology, University of Adelaide, Adelaide, 5005, Australia
,
A. A. Somogyi Department of Clinical and Experimental Pharmacology and Clinical Pharmacology, University of Adelaide, Adelaide, 5005, Australia
&
Z. R. Chen Department of Clinical and Experimental Pharmacology and Clinical Pharmacology, University of Adelaide, Adelaide, 5005, Australia
Pages 543-552 | Received 19 Nov 1993, Published online: 22 Sep 2008

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Poonam Giri, Prashant Delvadia, Laxmikant Gupta, Nirmal Patel, Priyal Trivedi, Krishna Lad, Hiren M. Patel & Nuggehally R. Srinivas. (2018) Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA. Xenobiotica 48:1, pages 1-10.
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Ruri Kikura-Hanajiri, Maiko Kawamura, Atsuko Miyajima, Momoko Sunouchi & Yukihiro Goda. (2011) Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS. Analytical and Bioanalytical Chemistry 400:1, pages 165-174.
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Adam R. Frymoyer, Michael C. Rowbotham & Karin Lottrup Petersen. (2007) Placebo-Controlled Comparison of a Morphine/Dextromethorphan Combination With Morphine on Experimental Pain and Hyperalgesia in Healthy Volunteers. The Journal of Pain 8:1, pages 19-25.
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Eric Scholar. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 5 .
Jean-Francois Marier, Jean-Luc Deschênes, Amal Hage, Eleftheria Seliniotakis, Ari Gritsas, Themis Flarakos, Francis Beaudry & Pascal Vachon. (2005) Enhancing the uptake of dextromethorphan in the CNS of rats by concomitant administration of the P-gp inhibitor verapamil. Life Sciences 77:23, pages 2911-2926.
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J. F. Marier, L. E. Pope, G. J. Yakatan, J. E. Berg, M. Stiles & P. Vachon. (2004) Influence of concomitant quinidine administration on dextromethorphan disposition in rats. Journal of Veterinary Pharmacology and Therapeutics 27:2, pages 111-114.
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Marika Pasternyk Di Marco, David J Edwards, Irving W Wainer & Murray P Ducharme. (2002) The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein. Life Sciences 71:10, pages 1149-1160.
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Ryotaro Azuma, Masahito Komuro, Sherry R Black & James M Mathews. (1999) The effect of repeat administration of GTS-21 on mixed-function oxidase activities in rat. Toxicology Letters 110:3, pages 137-144.
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Thomas H. Eichhold, Mike Quijano, William L. Seibel, Charles A. Cruze, Roy L.M. Dobson & Kenneth R. Wehmeyer. (1997) Highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method for the analysis of dextromethorphan in human plasma. Journal of Chromatography B: Biomedical Sciences and Applications 698:1-2, pages 147-154.
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Deborah A. Capon, Felix Bochner, Nicole Kerry, Gerd Mikus, Catherine Danz & Andrew A. Somogyi. (1996) The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans*. Clinical Pharmacology & Therapeutics 60:3, pages 295-307.
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Simranjit Kaur & Michael S. Starr. (1995) Antiparkinsonian action of dextromethorphan in the reserpine-treated mouse. European Journal of Pharmacology 280:2, pages 159-166.
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