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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 8
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Original Article

Disposition of gemcitabine in rat and dog after single and multiple dosings

Y. Esumi Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd, Tokai-mura, Naka-gun, Ibaraki, 319-11, Japan
,
K. Mitsugi Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd, Tokai-mura, Naka-gun, Ibaraki, 319-11, Japan
,
A. Takao Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd, Tokai-mura, Naka-gun, Ibaraki, 319-11, Japan
,
H. Seki Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd, Tokai-mura, Naka-gun, Ibaraki, 319-11, Japan
&
M. Kawai Division of Pharmaceutical Research and Development, Eli Lilly Japan, Chuo-ku, Kobe, 651, Japan
Pages 805-817 | Received 25 Nov 1993, Published online: 27 Aug 2009

Citations (10)

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Y. Esumi, K. Mitsugi, H. Seki, A. Takao & M. Kawai. (1994) Placental transfer, lacteal transfer and plasma protein binding of gemcitabine. Xenobiotica 24:10, pages 957-964.
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Articles from other publishers (9)

Chiara Bastiancich, Guillaume Bastiat & Frederic Lagarce. (2018) Gemcitabine and glioblastoma: challenges and current perspectives. Drug Discovery Today 23:2, pages 416-423.
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Joao Felipe de Brito Galvao, William C. Kisseberth, Sridhar Murahari, Saikaew Sutayatram, Dennis J. Chew & Nongnuch Inpanbutr. (2012) Effects of gemcitabine and gemcitabine in combination with carboplatin on five canine transitional cell carcinoma cell lines. American Journal of Veterinary Research 73:8, pages 1262-1272.
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J. Sigmond, R.J. Honeywell, T.J. Postma, C.M.F. Dirven, S.M. de Lange, K. van der Born, A.C. Laan, J.C.A. Baayen, C.J. Van Groeningen, A.M. Bergman, G. Giaccone & G.J. Peters. (2009) Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. Annals of Oncology 20:1, pages 182-187.
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Stephan A. Veltkamp, Dick Pluim, Olaf van Tellingen, Jos H. Beijnen & Jan H. M. Schellens. (2008) Extensive Metabolism and Hepatic Accumulation of Gemcitabine After Multiple Oral and Intravenous Administration in Mice. Drug Metabolism and Disposition 36:8, pages 1606-1615.
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Jan H. Beumer, Erin Joseph, Merrill J. Egorin, Robert S. Parker, David Z. D'argenio, Joseph M. Covey & Julie L. Eiseman. (2006) A Mass Balance and Disposition Study of the DNA Methyltransferase Inhibitor Zebularine (NSC 309132) and Three of Its Metabolites in Mice. Clinical Cancer Research 12:19, pages 5826-5833.
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K. J. FREISE & T. MARTIN-JIMENEZ. (2006) Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous infusion. Journal of Veterinary Pharmacology and Therapeutics 29:2, pages 147-152.
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K. J. FREISE & T. MARTIN-JIMENEZ. (2006) Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous bolus dosing and its in vitro pharmacodynamics. Journal of Veterinary Pharmacology and Therapeutics 29:2, pages 137-145.
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Antony S Moore & Barbara E Kitchell. (2003) New chemotherapy agents in veterinary medicine. Veterinary Clinics of North America: Small Animal Practice 33:3, pages 629-649.
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Johannes Rieger, Silke Durka, Johannes Streffer, Johannes Dichgans & Michael Weller. (1999) Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, BCL-2 and dexamethasone. European Journal of Pharmacology 365:2-3, pages 301-308.
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