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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 9
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Original Article

Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, Cynomolgus monkey and human precision-cut liver slices

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Pages 893-907 | Received 10 Mar 1994, Published online: 27 Aug 2009

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Yao Xiao, Yi-Kun Wang, Xue-Rong Xiao, Qi Zhao, Jian-Feng Huang, Wei-Feng Zhu & Fei Li. (2020) Metabolic profiling of coumarins by the combination of UPLC-MS-based metabolomics and multiple mass defect filter. Xenobiotica 50:9, pages 1076-1089.
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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki & Yasuhiro Uno. (2010) A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin. Xenobiotica 40:9, pages 621-629.
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Caitlin M. Brown, Brad Reisfeld & Arthur N. Mayeno. (2008) Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates. Drug Metabolism Reviews 40:1, pages 1-100.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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M. Umachandran, J. Howarth & C. Ioannides. (2004) Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica 34:8, pages 771-780.
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Lai‐Hao Wang & Chia‐Ling Lien. (2004) Determination of Urinary Metabolites of Coumarin in Human Urine by HPLC. Journal of Liquid Chromatography & Related Technologies 27:19, pages 3077-3088.
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B. G. Lake, S. E. Ball, J. Kao, A. B. Renwick, R. J. Price & J. A. Scatina. (2002) Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica 32:10, pages 835-847.
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A. B. Renwick, S. E. Ball, J. M. Tredger, R. J. Price, D. G. Walters, J. Kao, J. A. Scatina & B. G. Lake. (2002) Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices. Xenobiotica 32:10, pages 849-862.
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Akira Murakami, Keiji Wada, Naomi Ueda, Keiko Sasaki, Masanobu Haga, Wataru Kuki, Yasuo Takahashi, Hiroshi Yonei, Koichi Koshimizu & Hajime Ohigashi. (2000) In Vitro Absorption and Metabolism of a Citrus Chemopreventive Agent, Auraptene, and Its Modifying Effects on Xenobiotic Enzyme Activities in Mouse Livers. Nutrition and Cancer 36:2, pages 191-199.
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R. de KANTER, P. OLINGA, I. HOF, M. de JAGER, W. A. VERWILLEGEN, M. J. H. SLOOFF, H. J. KOSTER, D. K. F. MEIJER & G. M. M. GROOTHUIS. (1998) A rapid and simple method for cryopreservation of human liver slices. Xenobiotica 28:3, pages 225-234.
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R. J. PRICE, S. E. BALL, A. B. RENWICK, P. T. BARTON, J. A. BEAMAND & B. G. LAKE. (1998) Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers. Xenobiotica 28:4, pages 361-371.
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P. OLINGA, M. T. MEREMA, I. H. HOF, M. H. DE JAGER, K. P. DE JONG, M. J. H. SLOOFF, D. K. F. MEIJER & G. M. M. GROOTHUIS. (1998) Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver. Xenobiotica 28:4, pages 349-360.
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D. P. Bogan, B. Deasy, R. O'kennedy & M. R. Smyth. (1996) Interspecies differences in coumarin metabolism in liver microsomes examined by capillary electrophoresis. Xenobiotica 26:4, pages 437-445.
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B. G. Lake, M. J. Sauer, F. Esclangon, J. A. Beamand, R. J. Price & D. G. Walters. (1995) Metabolism of coumarin by precision-cut calf liver slices and calf liver microsomes. Xenobiotica 25:2, pages 133-141.
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M. V. Miroshnikov, K. T. Sultanova, M. N. Makarova & V. G. Makarov. (2022) A comparative review of the activity of enzymes of the cytochrome P450 system in humans and laboratory animals. Prognostic value of preclinical models in vivo. Translational Medicine 9:5, pages 44-77.
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Michele Pitaro, Nicoletta Croce, Valentina Gallo, Alyexandra Arienzo, Giulia Salvatore & Giovanni Antonini. (2022) Coumarin-Induced Hepatotoxicity: A Narrative Review. Molecules 27:24, pages 9063.
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Xiao‐fang Ma, Qi Zhao, Yan Cheng, Dong‐Mei Yan, Wei‐Feng Zhu & Fei Li. (2021) Metabolomics reveals the role of isopentenyl group in coumarins metabolism. Biomedical Chromatography 36:1.
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ChingYi Jennifer Hsieh, Meng Sun, Gwendolyn Osborne, Karin Ricker, Feng C. Tsai, Kate Li, Rajpal Tomar, Jimmy Phuong, Rose Schmitz & Martha S. Sandy. (2019) Cancer Hazard Identification Integrating Human Variability: The Case of Coumarin. International Journal of Toxicology 38:6, pages 501-552.
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Constanze Stiefel, Tina Schubert & Gertrud E. Morlock. (2017) Bioprofiling of Cosmetics with Focus on Streamlined Coumarin Analysis. ACS Omega 2:8, pages 5242-5250.
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Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2015) Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6. Drug Metabolism and Disposition 43:7, pages 969-976.
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Feixiong Cheng. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
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Carine Jacques, Elisabeth Perdu, Céline Dorio, Daniel Bacqueville, Alain Mavon & Daniel Zalko. (2010) Percutaneous absorption and metabolism of [14C]-ethoxycoumarin in a pig ear skin model. Toxicology in Vitro 24:5, pages 1426-1434.
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Robert A. Howd & Anna M. Fan. 2010. Cancer Risk Assessment. Cancer Risk Assessment 66 95 .
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Robert A. Howd. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Ivonne M.C.M. Rietjens, Marelle G. Boersma, Maria Zaleska & Ans Punt. (2008) Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling. Toxicology in Vitro 22:8, pages 1890-1901.
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Daphnee S. Pushparajah, Meera Umachandran, Tariq Nazir, Kathryn E. Plant, Nick Plant, David F.V. Lewis & Costas Ioannides. (2008) Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Toxicology in Vitro 22:1, pages 128-145.
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Marcella Martignoni, Ruben de Kanter, Anna Moscone, Pietro Grossi & Mario Monshouwer. (2004) Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice. Cancer Chemotherapy and Pharmacology 55:2, pages 129-135.
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. (2004) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Coumarin. EFSA Journal 2:12, pages 104.
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Jeffrey D. Vassallo, Sarah M. Hicks, George P. Daston & Lois D. Lehman-McKeeman. (2004) Metabolic Detoxification Determines Species Differences in Coumarin-Induced Hepatotoxicity. Toxicological Sciences 80:2, pages 249-257.
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S. Sivapathasundaram, L. C. Howells, M. J. Sauer & C. Ioannides. (2004) Functional integrity of precision-cut liver slices from deer and cattle. Journal of Veterinary Pharmacology and Therapeutics 27:2, pages 79-84.
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E. J. Perkins, J. W. Cramer, N. A. Farid, M. G. Gadberry, D. A. Jackson, E. L. Mattiuz, D. D. O'Bannon, H. J. Weiss, W. J. Wheeler, P. G. Wood & K. C. Cassidy. (2003) PRECLINICAL CHARACTERIZATION OF 2-[3-[3-[(5-ETHYL-4′-FLUORO-2-HYDROXY[1,1′-BIPHENYL]-4-YL)OXY]PROPOXY]-2-PROPYLPHENOXY]BENZOIC ACID METABOLISM: IN VITRO SPECIES COMPARISON AND IN VIVO DISPOSITION IN RATS. Drug Metabolism and Disposition 31:11, pages 1382-1390.
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E Hashemi, C Till & C Ioannides. (1999) Stability of Phase II Conjugation Systems in Cultured Precision-cut Rat Hepatic Slices. Toxicology in Vitro 13:3, pages 459-466.
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B.G Lake. (1999) Coumarin Metabolism, Toxicity and Carcinogenicity: Relevance for Human Risk Assessment. Food and Chemical Toxicology 37:4, pages 423-453.
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D.F.V Lewis, M Dickins, B.G Lake, P.J Eddershaw, M.H Tarbit & P.S Goldfarb. (1999) Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity. Toxicology 133:1, pages 1-33.
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J.A. Beamand, P.T. Barton, R.J. Price & B.G. Lake. (1998) Lack of Effect of Coumarin on Unscheduled DNA Synthesis in Precision-cut Human Liver Slices. Food and Chemical Toxicology 36:8, pages 647-653.
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Roger J. Price, Anthony B. Renwick, Paula T. Barton, J. Brian Houston & Brian G. Lake. (2020) Influence of Slice Thickness and Culture Conditions on the Metabolism of 7-Ethoxycoumarin in Precision-cut Rat Liver Slices. Alternatives to Laboratory Animals 26:4, pages 541-548.
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Evan D. Kharasch, Douglas C. Hankins, Pamela J. Baxter & Kenneth E. Thummel. (1998) Single-dose disulfiram does not inhibit CYP2A6 activity*. Clinical Pharmacology & Therapeutics 64:1, pages 39-45.
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Yan Li, Ning-Yuan Li & Edward M. Sellers. (1997) Comparison of CYP2A6 catalytic activity on coumarin 7-hydroxylation in human and monkey liver microsomes. European Journal of Drug Metabolism and Pharmacokinetics 22:4, pages 295-304.
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Peter Olinga, Marjolijn Merema, Maarten J.H. Slooff, Dirk K.F. Meijer & Geny M.M. Groothuis. (1997) Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes. Journal of Hepatology 27:4, pages 738-743.
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Cherukury Madhu, Peter Rix, David Small, Yang-Dar Yuan & Diane D.-S. Tang-Liu. (1997) The use of precision-cut rat lung slices for studying PGF2α metabolism. Environmental Toxicology and Pharmacology 3:4, pages 251-256.
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