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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 4
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Research Article

Pharmacokinetics of venlafaxine and O-desmethylvenlafaxine in laboratory animals

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Pages 315-327 | Received 02 Jul 1993, Published online: 22 Sep 2008

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Yilin Li, Yang Wang, Na Zhang, Shenzhi Zhou, Ying Peng & Jiang Zheng. (2021) Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine in vitro and in vivo. Xenobiotica 51:11, pages 1303-1317.
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Tjerk Bueters, Sanja Juric, Anna-Karin Sohlenius-Sternbeck, Yin Hu & Johan Bylund. (2013) Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human. Xenobiotica 43:7, pages 607-616.
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ALEJANDRO HERNÁANDEZ, LUIS CONSTANDIL, CLAUDIO LAURIDO, TERESA PELISSIER, FABIEN MARCHAND, DENIS ARDID, ABDELKRIM ALLOUI, ALAIN ESCHALIER & RUBÉN SOTO-MOYANO. (2004) VENLAFAXINE-INDUCED DEPRESSION OF WIND-UP ACTIVITY IN MONONEUROPATHIC RATS IS POTENTIATED BY INHIBITION OF BRAIN 5-HT1A RECEPTOR EXPRESSION IN VIVO. International Journal of Neuroscience 114:2, pages 229-242.
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Articles from other publishers (33)

Natalie N. Maffeo, Cary M. Springer & Julia D. Albright. (2023) A retrospective study on the clinical use and owner perception of venlafaxine efficacy as part of a multimodal treatment for canine fear, anxiety, and aggression. Journal of Veterinary Behavior 64-65, pages 54-59.
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Abdul Aala Fazli, Bala Krishna Panigrahy, Varinder Kumar, Syed Naiem Raza, Bilal Ahmad Zarger, Taha Umair Wani, Shavej Ahmad, Arshad Khuroo & Nisar Ahmad Khan. (2022) Multiple-reaction monitoring (MRM) LC–MS/MS quantitation of venlafaxine and its O-desmethyl metabolite for a preclinical pharmacokinetic study in rabbits. Scientific Reports 12:1.
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Delphine Metz, Tiphaine Medam & Sylvia Masson. (2021) Double-blind, placebo-controlled trial of venlafaxine to treat behavioural disorders in cats: a pilot study. Journal of Feline Medicine and Surgery 24:6, pages 539-549.
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Karen L. Overall. 2019. Pharmacotherapeutics for Veterinary Dispensing. Pharmacotherapeutics for Veterinary Dispensing 377 401 .
Karol A. Mathews, Melissa Sinclair, Andrea M. Steele & Tamara GrubbKarol Mathews. 2018. Analgesia and Anesthesia for the Ill or Injured Dog and Cat. Analgesia and Anesthesia for the Ill or Injured Dog and Cat 17 50 .
Karol A. Mathews, Melissa Sinclair, Andrea M. Steele & Tamara GrubbKarol Mathews & Tamara Grubb. 2018. Analgesia and Anesthesia for the Ill or Injured Dog and Cat. Analgesia and Anesthesia for the Ill or Injured Dog and Cat 144 164 .
Guodong Gu, Michelle Black, Colt Cookson, Anna Fiorella, Yinghe Li, Steven H. Gorman & Ray Bakhtiar. (2018) Validation of an LC-MS/MS method for simultaneous quantification of venlafaxine and its five metabolites in rat plasma and its application in a pharmacokinetic study. Journal of Chromatography B 1087-1088, pages 29-35.
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Mark E. Epstein. 2018. Canine Sports Medicine and Rehabilitation. Canine Sports Medicine and Rehabilitation 479 501 .
Rui Xue, Ying Li, Xin-Hua He, Zeng-Liang Jin, Shi-Yong Fan, Ting-Ting Zhang, Nuo-Min Li, Li Yuan, Ai-Ping Zheng, Bo-Hua Zhong, Yun-Feng Li & You-Zhi Zhang. (2016) Pharmacokinetic profiles contribute to the differences in behavioral pharmacology of 071031B enantiomers as novel serotonin and norepinephrine reuptake inhibitors. Journal of Psychopharmacology 31:3, pages 377-386.
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Diego Castanares-Zapatero, Nathalie Gillard, Arnaud Capron, Vincent Haufroid & Philippe Hantson. (2016) Reversible cardiac dysfunction after venlafaxine overdose and possible influence of genotype and metabolism. Forensic Science International 266, pages e48-e51.
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Qiong‐Yin Fan, Rui Xue, Ying Li, Ting‐Ting Zhang, Xin‐Hua He, Shi‐Yong Fan, Yun‐Feng Li, Bo‐Hua Zhong, You‐Zhi Zhang & Jin Li. (2016) Antidepressant‐like Effects of ZBH 2012001, a Novel Potent Serotonin and Norepinephrine Reuptake Inhibitor . CNS Neuroscience & Therapeutics 22:8, pages 700-706.
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José I. Serrano-Contreras, Isabel García-Pérez, María E. Meléndez-Camargo & Luis G. Zepeda-Vallejo. (2016) NMR-based metabonomic analysis of normal rat urine and faeces in response to (±)-venlafaxine treatment. Journal of Pharmaceutical and Biomedical Analysis 123, pages 82-92.
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Mark E. Epstein. (2014) Adjunctive, Pain-Modifying, Analgesic Drugs. Topics in Companion Animal Medicine 29:2, pages 30-34.
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Butch KuKanich. (2013) Outpatient Oral Analgesics in Dogs and Cats Beyond Nonsteroidal Antiinflammatory Drugs. Veterinary Clinics of North America: Small Animal Practice 43:5, pages 1109-1125.
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园园 朱. (2013) Synthesis of Venlafaxine Hydrochloride. Studies in Synthetic Chemistry 01:01, pages 1-3.
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Loren M. Berry, Chao Li & Zhiyang Zhao. (2011) Species Differences in Distribution and Prediction of Human V ss from Preclinical Data . Drug Metabolism and Disposition 39:11, pages 2103-2116.
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Kosalaram Goteti, C.Edwin Garner & Iftekhar Mahmood. (2010) Prediction of Human Drug Clearance from Two Species: A Comparison of Several Allometric Methods. Journal of Pharmaceutical Sciences 99:3, pages 1601-1613.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state. Journal of Pharmacy and Pharmacology 55:7, pages 939-949.
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Luis Delucchi, Pedro Martino, Alicia Baldovino, Paula Pessina & Álvaro Rodrigues. (2010) Use of venlafaxine in the treatment of a canine narcolepsy-cataplexy case. Journal of Small Animal Practice 51:2, pages 132-132.
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Iftekhar Mahmood. (2009) Role of Fixed Coefficients and Exponents in the Prediction of Human Drug Clearance: How Accurate are the Predictions from One or Two Species?. Journal of Pharmaceutical Sciences 98:7, pages 2472-2493.
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N.R. Mirza, E.Ø. Nielsen & K.B. Troelsen. (2007) Serotonin transporter density and anxiolytic-like effects of antidepressants in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 31:4, pages 858-866.
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K. B. Troelsen, E. Ø. Nielsen & N. R. Mirza. (2005) Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter. Psychopharmacology 181:4, pages 741-750.
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Fabien Marchand, Teresa Pelissier, Alain Eschalier, Denis Ardid, Abdelkrim Alloui, Rubén Soto-Moyano, Mauricio Mondaca, Claudio Laurido, Luis Constandil & Alejandro Hernández. (2004) Blockade of supraspinal 5-HT1A receptors potentiates the inhibitory effect of venlafaxine on wind-up activity in mononeuropathic rats. Brain Research 1008:2, pages 288-292.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Iftekhar Mahmood, Martin David Green & J. Edward Fisher. (2003) Selection of the First-Time Dose in Humans: Comparison of Different Approaches Based on Interspecies Scaling of Clearance. The Journal of Clinical Pharmacology 43:7, pages 692-697.
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Fabien Marchand, Abdelkrim Alloui, Eric Chapuy, Didier Jourdan, Teresa Pelissier, Denis Ardid, Alejandro Hernandez & Alain Eschalier. (2003) Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats. Pain 103:3, pages 229-235.
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Fabien Marchand, Abdelkrim Alloui, Eric Chapuy, Alejandro Hernandez, Teresa Pelissier, Denis Ardid & Alain Eschalier. (2003) The antihyperalgesic effect of venlafaxine in diabetic rats does not involve the opioid system. Neuroscience Letters 342:1-2, pages 105-108.
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Julie G Hensler. (2003) Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. Life Sciences 72:15, pages 1665-1682.
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Iftekhar Mahmood. (2002) Interspecies Scaling: Predicting Oral Clearance in Humans. American Journal of Therapeutics 9:1, pages 35-42.
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A Frazer & S Benmansour. (2002) Delayed pharmacological effects of antidepressants. Molecular Psychiatry 7:S1, pages S23-S28.
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I. Mahmood. (2001) Interspecies Scaling: Is a priori Knowledge of Cytochrome P450 Isozymes Involved in Drug Metabolism Helpful in Prediction of Clearance in Humans from Animal Data?. Drug Metabolism and Drug Interactions 18:2.
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Gustav Apelqvist, Cecilia Wikell, Björn Carlsson, Stephan Hjorth, Peter B.F. Bergqvist, Johan Ahlner & Finn Bengtsson. (2000) Dynamic and Kinetic Effects of Chronic Citalopram Treatment in Experimental Hepatic Encephalopathy. Clinical Neuropharmacology 23:6, pages 304-317.
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Jean‐Claude Béïque, Claude de Montigny, Pierre Blier & Guy Debonnel. (2009) Blockade of 5‐Hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine. British Journal of Pharmacology 125:3, pages 526-532.
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