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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 9
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Research Article

Metabolism of methoxyphenamine and 2-methoxyamphetamine in P4502D6-transfected cells and cell preparations

S. Geertsen Bureau of Drug Research, Sir Frederick G. Banting Research Centre, Health Protection Branch, Health Canada, Ottawa, Ontario, K1A OL2, Canada
,
B. C. Foster Bureau of Drug Research, Sir Frederick G. Banting Research Centre, Health Protection Branch, Health Canada, Ottawa, Ontario, K1A OL2, Canada
,
D. L. Wilson Bureau of Drug Research, Sir Frederick G. Banting Research Centre, Health Protection Branch, Health Canada, Ottawa, Ontario, K1A OL2, Canada
,
T. D. Cyr Bureau of Drug Research, Sir Frederick G. Banting Research Centre, Health Protection Branch, Health Canada, Ottawa, Ontario, K1A OL2, Canada
&
W. Casley Bureau of Drug Research, Sir Frederick G. Banting Research Centre, Health Protection Branch, Health Canada, Ottawa, Ontario, K1A OL2, Canada
Pages 895-906 | Received 23 Jan 1995, Published online: 22 Sep 2008

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Read on this site (3)

Kevin A. Ford, Gregory Ryslik, Jasleen Sodhi, Jason Halladay, Dolo Diaz, Donna Dambach & Melisa Masuda. (2015) Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications. Drug Metabolism Reviews 47:3, pages 291-319.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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MIMI V. BACH, R. T. COUTTS & G. B. BAKER. (1999) Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica 29:7, pages 719-732.
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Articles from other publishers (10)

Jianing Li, Severin T. Schneebeli, Joseph Bylund, Ramy Farid & Richard A. Friesner. (2011) IDSite: An Accurate Approach to Predict P450-Mediated Drug Metabolism. Journal of Chemical Theory and Computation 7:11, pages 3829-3845.
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Rayomand J. Unwalla, Jason B. Cross, Sumeet Salaniwal, Adam D. Shilling, Louis Leung, John Kao & Christine Humblet. (2010) Using a homology model of cytochrome P450 2D6 to predict substrate site of metabolism. Journal of Computer-Aided Molecular Design 24:3, pages 237-256.
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Mario Thevis, Gerd Sigmund, Anja Koch, Sven Guddat, Hans H. Maurer & Wilhelm Schänzer. (2008) Doping Control Analysis of Methoxyphenamine Using Liquid Chromatography-Tandem Mass Spectrometry. European Journal of Mass Spectrometry 14:3, pages 145-152.
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Nuggehally R. Srinivas. (2006) Drug disposition of chiral and achiral drug substrates metabolized by cytochrome P450 2D6 isozyme: case studies, analytical perspectives and developmental implications. Biomedical Chromatography 20:6-7, pages 466-491.
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Rafael de la Torre, Mag?? Farr??M??nica Navarro, Roberta Pacifici, Piergiorgio Zuccaro & Simona Pichini. (2004) Clinical Pharmacokinetics of Amfetamine and Related Substances. Clinical Pharmacokinetics 43:3, pages 157-185.
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Tony Antoniou & Alice Lin-In Tseng. (2016) Interactions between Recreational Drugs and Antiretroviral Agents. Annals of Pharmacotherapy 36:10, pages 1598-1613.
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Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne, Alexander A. Alex & Barry C. Jones. (1999) A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6. Journal of Medicinal Chemistry 42:20, pages 4062-4070.
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Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne, Alexander A. Alex & Barry C. Jones. (1999) Novel Approach To Predicting P450-Mediated Drug Metabolism:  Development of a Combined Protein and Pharmacophore Model for CYP2D6. Journal of Medicinal Chemistry 42:9, pages 1515-1524.
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Lynette C. Kirkwood, Roger L. Nation & Andrew A. Somogyi. (1997) Determination of the dihydrocodeine metabolites, dihydromorphine and nordihydrocodeine, in hepatic microsomal incubations by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 701:1, pages 129-134.
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B. C. Foster, D. L. Wilson, T. Marwood, J. C. Ethier & J. Zamecnik. (1996) Microbial transformation of 3,4-methylenedioxy- N -methylamphetamine and 3,4-methylenedioxyamphetamine . Canadian Journal of Microbiology 42:8, pages 851-854.
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