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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 9
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Research Article

Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine

J. C. Bloomer Department of Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, AL6 9AR, UK
,
S. E. Clarke Department of Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, AL6 9AR, UK
&
R. J. Chenery Department of Drug Metabolism and Pharmacokinetics, SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, AL6 9AR, UK
Pages 917-927 | Received 18 Feb 1995, Published online: 22 Sep 2008

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Dennis Rokitta, Kay Pfeiffer, Christina Streich, Henrik Gerwin & Uwe Fuhr. (2013) The effect of organic solvents on enzyme kinetic parameters of human CYP3A4 and CYP1A2 in vitro. Toxicology Mechanisms and Methods 23:8, pages 576-583.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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H. Yin, J. Racha, S.-Y. Li, N. Olejnik, H. Satoh & D. Moore. (2000) Automated high throughput human CYP isoform activity assay using SPE-LC/MS method: application in CYP inhibition evaluation. Xenobiotica 30:2, pages 141-154.
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G. C. MOODY. (1999) Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential. Xenobiotica 29:1, pages 53-75.
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S. E. CLARKE. (1998) In vitro assessment of human cytochrome P450. Xenobiotica 28:12, pages 1167-1202.
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Articles from other publishers (16)

Zeyad Alehaideb, Mohamed Sheriffdeen & Francis C. P. Law. (2021) Inhibition of Caffeine Metabolism by Apiaceous and Rutaceae Families of Plant Products in Humans: In Vivo and In Vitro Studies. Frontiers in Pharmacology 12.
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Javor Mitkov, Magdalena Kondeva-Burdina & Alexander Zlatkov. (2019) Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives. Pharmacia 66:3, pages 99-106.
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Mohamed M. Sheriffdeen, Zeyad I. Alehaideb & Francis C.P. Law. (2019) Caffeine/Angelica dahurica and caffeine/Salvia miltiorrhiza metabolic inhibition in humans: In vitro and in vivo studies. Complementary Therapies in Medicine 46, pages 87-94.
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Zeyad Alehaideb, Kimberly C. Chin, Mei Cun Yao & Francis C.P. Law. (2019) Predicting the content of anthraquinone bioactive in Rhei rhizome (Rheum officinale Baill.) with the concentration addition model. Saudi Pharmaceutical Journal 27:1, pages 25-32.
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Mohamed B. Abou-Donia. 2015. Mammalian Toxicology. Mammalian Toxicology 101 129 .
Angela Dudda & Gert Ulrich Kuerzel. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 989 1004 .
Dan Rock, Jan Wahlstrom & Larry Wienkers. 2008. Antitargets. Antitargets 195 246 .
Angela Dudda & Gert Ulrich Kürzel. 2006. Drug Discovery and Evaluation. Drug Discovery and Evaluation 551 557 .
Kiyomi Ito & J. Brian Houston. (2005) Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches. Pharmaceutical Research 22:1, pages 103-112.
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Jagdish K. Racha, Z. Sylvia Zhao, Nicholas Olejnik, Nadine Warner, Rebecca Chan, David Moore & Hiroko Satoh. (2003) Substrate Dependent Inhibition Profiles of Fourteen Drugs on CYP3A4 Activity Measured by A High Throughput LCMS/MS Method with Four Probe Drugs, Midazolam, Testosterone, Nifedipine and Terfenadine. Drug Metabolism and Pharmacokinetics 18:2, pages 128-138.
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Florence Grand, Izzet Kilinc, Albert Sarkis & Jérôme Guitton. (2002) Application of Isotopic Ratio Mass Spectrometry for the in Vitro Determination of Demethylation Activity in Human Liver Microsomes Using N-methyl-13C-Labeled Substrates. Analytical Biochemistry 306:2, pages 181-187.
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Enock Delaporte & A. David Rodrigues. (2002) Cytochrome P450 Assays. Current Protocols in Pharmacology 15:1.
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Mohamed Abou-Donia, Eman Elmasry & Aqel Abu-Qare. 2001. Handbook of Toxicology, Second Edition. Handbook of Toxicology, Second Edition.
Baldwin, Clarke & Chenery. (1999) Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone . British Journal of Clinical Pharmacology 48:3, pages 424-432.
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Robert J. Riley & D. Howbrook. (1997) In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-methyl-14C]-erythromycin. Journal of Pharmacological and Toxicological Methods 38:4, pages 189-193.
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A. David Rodrigues & Shekman L. Wong. 1997. 65 101 .

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