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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 11
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Research Article

Meloxicam: metabolic profile and biotransformation products in the rat

J. Schmid Dr Karl Thomae GmbH, Department of Pharmacokinetics and Drug Metabolism, and Department of Medical Chemistry, D-88397, Biberach/Riss, Germany
,
U. Busch Dr Karl Thomae GmbH, Department of Pharmacokinetics and Drug Metabolism, and Department of Medical Chemistry, D-88397, Biberach/Riss, Germany
,
G. Trummlitz Dr Karl Thomae GmbH, Department of Pharmacokinetics and Drug Metabolism, and Department of Medical Chemistry, D-88397, Biberach/Riss, Germany
,
A. Prox Dr Karl Thomae GmbH, Department of Pharmacokinetics and Drug Metabolism, and Department of Medical Chemistry, D-88397, Biberach/Riss, Germany
,
S. Kaschke Dr Karl Thomae GmbH, Department of Pharmacokinetics and Drug Metabolism, and Department of Medical Chemistry, D-88397, Biberach/Riss, Germany
&
H. Wachsmuth Dr Karl Thomae GmbH, Department of Pharmacokinetics and Drug Metabolism, and Department of Medical Chemistry, D-88397, Biberach/Riss, Germany
Pages 1219-1236 | Received 20 Apr 1995, Published online: 22 Sep 2008

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Graham Lappin & Lloyd Stevens. (2008) Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 4:8, pages 1021-1033.
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Manfred Schattenkirchner. (1997) Meloxicam:a selective COX-2 inhibitor non-steroidal anti-inflammatory drug. Expert Opinion on Investigational Drugs 6:3, pages 321-334.
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Xue Bai, Dan Qin & Lijun Yang. (2021) Importance of substituents in ring opening: a DFT study on a model reaction of thiazole to thioamide. Journal of Molecular Modeling 27:3.
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Emmanuel Oluwasegun Adawaren, Lillian Mukandiwa, John Chipangura, Kerri Wolter & Vinny Naidoo. (2019) Percentage of faecal excretion of meloxicam in the Cape vultures (Gyps corprotheres). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 215, pages 41-46.
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Kimihiro Komeyama, Yuta Yamahata & Itaru Osaka. (2018) Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p -Toluenesulfonate . Organic Letters 20:14, pages 4375-4378.
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Jeffrey Y. W. Mak, Weijun Xu & David P. Fairlie. 2017. Peptidomimetics I. Peptidomimetics I 235 266 .
B. Kimble, K.M. Li, P. Valtchev, D.P. Higgins, M.B. Krockenberger & M. Govendir. (2014) In vitro hepatic microsomal metabolism of meloxicam in koalas (Phascolarctos cinereus), brushtail possums (Trichosurus vulpecula), ringtail possums (Pseudocheirus peregrinus), rats (Rattus norvegicus) and dogs (Canis lupus familiaris). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 161, pages 7-14.
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Xin Zhou. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 5 .
I. A. WASFI, W. A. AL ALI, B. A. AGHA, A. M. KAMEL, N. A AL BIRIKI & K. M. AL NEAIMI. (2011) The pharmacokinetics and metabolism of meloxicam in camels after intravenous administration. Journal of Veterinary Pharmacology and Therapeutics 35:2, pages 155-162.
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John S. WalshGerald T. Miwa. (2011) Bioactivation of Drugs: Risk and Drug Design. Annual Review of Pharmacology and Toxicology 51:1, pages 145-167.
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Yohannes Teffera, Deborah Choquette, Jingzhou Liu, Adria E. Colletti, L. Steven Hollis, Min-Hwa Jasmine Lin & Zhiyang Zhao. (2010) Bioactivation of Isothiazoles: Minimizing the Risk of Potential Toxicity in Drug Discovery. Chemical Research in Toxicology 23:11, pages 1743-1752.
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Donald J. AbrahamJulian Blagg. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 301 334 .
Graham Lappin & Mark Seymour. (2010) Addressing metabolite safety during first-in-man studies using 14 C-labeled drug and accelerator mass spectrometry . Bioanalysis 2:7, pages 1315-1324.
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P. GRUDE, J. GUITTARD, C. GARCIA, I. DAOULAS, F. THOULON & T. EBNER. (2010) Excretion mass balance evaluation, metabolite profile analysis and metabolite identification in plasma and excreta after oral administration of [14C]-meloxicam to the male cat: preliminary study. Journal of Veterinary Pharmacology and Therapeutics, pages no-no.
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Stephanos Ioannidis, Michelle L. Lamb, Lynsie Almeida, Huiping Guan, Bo Peng, Geraldine Bebernitz, Kirsten Bell, Marat Alimzhanov & Michael Zinda. (2010) Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors. Bioorganic & Medicinal Chemistry Letters 20:5, pages 1669-1673.
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Annica Tevell Åberg, Charlotte Olsson, Ulf Bondesson & Mikael Hedeland. (2009) A mass spectrometric study on meloxicam metabolism in horses and the fungus Cunninghamella elegans, and the relevance of this microbial system as a model of drug metabolism in the horse . Journal of Mass Spectrometry 44:7, pages 1026-1037.
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Hye Won LeeHye Young JiHoi Yun Kim, Kang Choon Lee & Hye Suk Lee. (2009) Liquid chromatography–tandem mass spectrometry method for the determination of meloxicam and its metabolite 5-carboxymeloxicam in human plasma. Bioanalysis 1:1, pages 63-70.
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R. Scott Obach, Amit S. Kalgutkar, Tim F. Ryder & Gregory S. Walker. (2008) In Vitro Metabolism and Covalent Binding of Enol-Carboxamide Derivatives and Anti-Inflammatory Agents Sudoxicam and Meloxicam: Insights into the Hepatotoxicity of Sudoxicam . Chemical Research in Toxicology 21:9, pages 1890-1899.
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J.M. Herbert. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 977 1092 .
Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:9, pages 2031-2122.
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Frédéric Balssa & Yves Bonnaire. (2007) Synthesis of deuterium‐labelled meloxicam and piroxicam. Journal of Labelled Compounds and Radiopharmaceuticals 50:3, pages 207-210.
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Graham Lappin. 2006. Radiotracers in Drug Development. Radiotracers in Drug Development 41 118 .
K. D. Rainsford. 2004. COX-2 Inhibitors. COX-2 Inhibitors 67 131 .
M. C. Dumasia. (2003) In vivo biotransformation of 17α‐methyltestosterone in the horse revisited: identification of 17‐hydroxymethyl metabolites in equine urine by capillary gas chromatography/mass spectrometry . Rapid Communications in Mass Spectrometry 17:4, pages 320-329.
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D. E. Furst. 1998. Selective COX-2 Inhibitors. Selective COX-2 Inhibitors 135 144 .
Daniel E. Furst. (1997) Meloxicam: Selective COX-2 inhibition in clinical practice. Seminars in Arthritis and Rheumatism 26, pages 21-27.
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H. A. Lehmann, M. Baumeister, L. Lützen & J. Wiegleb. (1996) Meloxicam: A toxicology overview. Inflammopharmacology 4:2, pages 105-123.
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