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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 11
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Research Article

Pharmacokinetics of barnidipine hydrochloride, a new dihydropyridine calcium channel blocker, in the rat, dog and human

T. Teramura Drug Metabolism Department, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd, 1–8, Azusawa 1-chome, Itabashi-ku, Tokyo, 174, Japan
,
T. Watanabe Drug Metabolism Department, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd, 1–8, Azusawa 1-chome, Itabashi-ku, Tokyo, 174, Japan
,
S. Higuchi Drug Metabolism Department, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd, 1–8, Azusawa 1-chome, Itabashi-ku, Tokyo, 174, Japan
&
K. Hashimoto Department of Pharmacology, Yamanashi Medical College, Tamaho, Nakakoma-gun, Yamanashi, 409–38, Japan
Pages 1237-1246 | Received 23 Jan 1995, Published online: 22 Sep 2008

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Dosha F Cummins. (1999) Newer calcium channel antagonists and the treatment of hypertension. Expert Opinion on Investigational Drugs 8:7, pages 1031-1042.
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T. TERAMURA*T. WATANABE, S. HIGUCHI & K. HASHIMOTO. (1997) Metabolism and pharmacokinetics of barnidipine hydrochloride, a calcium channel blocker, in man following oral administration of its sustained release formulation. Xenobiotica 27:2, pages 203-216.
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T. TERAMURA*Y. FUKUNAGA, E. J. VAN HOOGDALEM, T. WATANABE & S. HIGUCHI. (1997) Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker. Xenobiotica 27:9, pages 885-900.
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Articles from other publishers (9)

Atul A. Shirkhedkar & Suraj R. Chaudhari. (2021) Exploring an experimental combination of analytical quality by design and green analytical chemistry approaches for development of HPTLC densitometric protocol for the analysis of barnidipine hydrochloride. Biomedical Chromatography 36:1.
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Toshiro Niwa, Shinji Honda, Kiyoharu Shirakawa, Yasushi Imamura, Sadayuki Osaki & Akira Takagi. (2006) Drug interaction of fluvoxamine, a selective serotonin reuptake inhibitor. Folia Pharmacologica Japonica 128:2, pages 93-103.
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Shahab Bohlooli, Fariborz Keyhanfar & Massoud Mahmoudian. (2004) Pharmacokinetics of mebudipine, a new calcium antagonist, following single intravenous and oral administrations in rats. Biopharmaceutics & Drug Disposition 25:4, pages 187-191.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Nobuo Inotsume & Masahiro Nakano. (2002) Stereoselective determination and pharmacokinetics of dihydropyridines: an updated review. Journal of Biochemical and Biophysical Methods 54:1-3, pages 255-274.
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Kenjiro Kimura, Naoe Suzuki, Naobumi Mise, Shigeyoshi Oba, Kazuhisa Miyashita, Akihiro Tojo, Yasunobu Hirata, Atsuo Goto & Masao Omata. (1998) Effects of barnidipine hydrochloride, a calcium channel blocker, on renal microcirculation in rats: a pilot study. Current Therapeutic Research 59:12, pages 826-834.
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M. Pawula, D. Watson, T. Teramura, T. Watanabe, S. Higuchi & K.N. Cheng. (1998) Sensitive and specific liquid chromatographic–tandem mass spectrometric assay for barnidipine in human plasma. Journal of Chromatography B: Biomedical Sciences and Applications 719:1-2, pages 113-123.
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Toshiharu Sakai, Toshio Teramura, Hideaki Okamiya & Osamu Inagaki. (2007) A Review on Barnidipine: A Novel Calcium Antagonist. Cardiovascular Drug Reviews 15:4, pages 273-290.
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J G SarverD WhiteP ErhardtK Bachmann. (1997) Estimating xenobiotic half-lives in humans from rat data: influence of log P.. Environmental Health Perspectives 105:11, pages 1204-1209.
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