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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 1
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Research Article

Effects of 5-fluorouracil treatment on rat liver microsomal enzymes

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Pages 1-8 | Received 19 May 1994, Published online: 22 Sep 2008

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Shuhei Fukuno, Katsuhito Nagai, Mai Fujiike, Yuya Sasaki & Hiroki Konishi. (2019) Conflicting alterations in hepatic expression of CYP3A and enzyme kinetics in rats exposed to 5-fluorouracil: relevance to pharmacokinetics of midazolam. Xenobiotica 49:12, pages 1470-1477.
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Shuhei Fukuno, Katsuhito Nagai, Keita Kasahara, Yuki Mizobata, Sachiko Omotani, Yasutoshi Hatsuda, Michiaki Myotoku & Hiroki Konishi. (2018) Altered tolbutamide pharmacokinetics by a decrease in hepatic expression of CYP2C6/11 in rats pretreated with 5-fluorouracil. Xenobiotica 48:1, pages 53-59.
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Mohammad Reza Eskandari, Faezeh Moghaddam, Jafar Shahraki & Jalal Pourahmad. (2015) A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine. Xenobiotica 45:1, pages 79-87.
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E. J. Jones & D. S. Riddick. (1996) Regulation of constitutive rat hepatic cytochromes P450 by 3-methylcholanthrene. Xenobiotica 26:10, pages 995-1012.
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R. L. H. Cheung, C. Lee, E. J. Jones & D. S. Riddick. (1996) Lack of effect of methotrexate on the expression of constitutive hepatic cytochromes P450 in the male rat. Xenobiotica 26:5, pages 503-514.
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Tsuyoshi Hata, Toshihiro Kudo, Daisuke Sakai, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori & Taroh Satoh. (2016) Impact of capecitabine and S-1 on anticoagulant activity of warfarin in patients with gastrointestinal cancer. Cancer Chemotherapy and Pharmacology 78:2, pages 389-396.
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Keiko Yamamura, Koji Yano, Yoshiki Hirooka, Akihiro Hirashiki, Toyoaki Murohara & Kiyofumi Yamada. (2015) A Successful Case of a Patient Undergoing Warfarin and S-1 Therapy Using Internet-based Control of Home-measured PT-INRA Successful Case of a Patient Undergoing Warfarin and S-1 Therapy Using Internet-based Control of Home-measured PT-INR. YAKUGAKU ZASSHI 135:7, pages 925-927.
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Yutaka Negoro, Takashi Higashi, Hiroaki Matsuoka, Kyohei Watanabe, Toshiaki Igarashi, Yuichiro Kayano, Ryoichi Yano, Toshiaki Nakamura & Mikio Masada. (2014) Variations in the Blood Phenytoin Levels during Long-Term Combined Treatment with S-1 and Phenytoin. Case Reports in Oncology 7:3, pages 656-661.
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Hiroki Konishi, Takashi Yoshimoto, Kunihiko Morita, Tokuzo Minouchi, Takashi Sato & Akira Yamaji. (2003) Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats. Journal of Pharmacy and Pharmacology 55:1, pages 143-149.
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Aiko Tsuda, Junshin Fujiyama, Akiko Miki, Satoko Hori, Hisakazu Ohtani & Yasufumi Sawada. (2007) The first case of phenytoin intoxication associated with the concomitant use of phenytoin and TS-1, a combination preparation of tegafur, gimeracil, and oteracil potassium. Cancer Chemotherapy and Pharmacology 62:3, pages 427-432.
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Arzu Gunes, Ugur Coskun, Cem Boruban, Nazan Gunel, Melih O. Babaoglu, Orhan Sencan, Atila Bozkurt, Anders Rane, Moustapha Hassan, Hakan Zengil & Umit Yasar. (2006) Inhibitory Effect of 5-Fluorouracil on Cytochrome P450 2C9 Activity in Cancer Patients. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 98:2, pages 197-200.
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Qingyu Zhou & Eli Chan. (2002) Effect of 5-fluorouracil on the anticoagulant activity and the pharmacokinetics of warfarin enantiomers in rats. European Journal of Pharmaceutical Sciences 17:1-2, pages 73-80.
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Hiroki Konishi, Kunihiko Morita, Tokuzo Minouchi, Masayuki Nakajima, Masayuki Matsuda & Akira Yamaji. (2016) Probable Metabolic Interaction of Doxifluridine with Phenytoin. Annals of Pharmacotherapy 36:5, pages 831-834.
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Setsuko TAKIZAWA & Ikuo HORII. (2002) ENDOCRINOLOGICAL ASSESSMENT OF TOXIC EFFECTS ON THE MALE REPRODUCTIVE SYSTEM IN RATS TREATED WITH 5-FLUOROURACIL FOR 2 OR 4 WEEKS. The Journal of Toxicological Sciences 27:1, pages 49-56.
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I Stupans, M Murray, A Kirlich, K.L Tuck & P.J Hayball. (2001) Inactivation of cytochrome P450 by the food-derived complex phenol oleuropein. Food and Chemical Toxicology 39:11, pages 1119-1124.
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Georgia J Pass, Stuart McLean & Ieva Stupans. (1999) Induction of xenobiotic metabolising enzymes in the common brushtail possum, Trichosurus vulpecula, by Eucalyptus terpenes. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 124:3, pages 239-246.
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H.L. McLeod, J. Sludden, S.C. Hardy, R.E. Lock, G.M. Hawksworth & J. Cassidy. (1998) Autoregulation of 5-fluorouracil metabolism. European Journal of Cancer 34:10, pages 1623-1627.
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A. Vermes, H.-J. Guchelaar & R.P. Koopmans. (1997) Individualization of cancer therapy based on cytochrome P450 polymorphism: a pharmacogenetic approach. Cancer Treatment Reviews 23:5-6, pages 321-339.
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Michael C. Brown. (2012) Multisite Mucous Membrane Bleeding Due to a Possible Interaction Between Warfarin and 5‐Fluorouracil. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17:3, pages 631-633.
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Armaghan Afsar, Chunja Lee & David S Riddick. (1996) Modulation of the expression of constitutive rat hepatic cytochrome P450 isozymes by 5-fluorouracil. Canadian Journal of Physiology and Pharmacology 74:2, pages 150-156.
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