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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 1
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Research Article

Species variation in the bioactivation of tacrine by hepatic microsomes

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Pages 103-116 | Received 24 Aug 1994, Published online: 22 Sep 2008

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Amit S Kalgutkar & John R Soglia. (2005) Minimising the potential for metabolic activation in drug discovery. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 91-142.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Jennie L. Walgren, Michael D. Mitchell & David C. Thompson. (2005) Role of Metabolism in Drug-Induced Idiosyncratic Hepatotoxicity. Critical Reviews in Toxicology 35:4, pages 325-361.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Slobodan Rendic & Frederick J. Di Carlo. (1997) Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors. Drug Metabolism Reviews 29:1-2, pages 413-580.
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D. K. Monteith, M. R. Emmerling, J. Garvin & J. C. Theiss. (1996) Cytotoxicity Study of Tacrine, Structurally and Pharmacologically Related Compounds Using Rat Hepatocytes. Drug and Chemical Toxicology 19:1-2, pages 71-84.
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M. Novak, B. Svobodova, J. Konecny, A. Kuratkova, L. Nevosadova, L. Prchal, J. Korabecny, V.M. Lauschke, O. Soukup & R. Kučera. (2023) UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes. Journal of Pharmaceutical and Biomedical Analysis 224, pages 115154.
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Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 79 137 .
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Mansour K. Gatasheh, S. Kannan, K. Hemalatha & N. Imrana. (2017) Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science 3:4, pages 272-278.
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Katharina Zenger, Xinyu Chen, Michael Decker & Birgit Kraus. (2013) In-vitro stability and metabolism of a tacrine–silibinin codrug. Journal of Pharmacy and Pharmacology 65:12, pages 1765-1772.
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Alexander V. LyubimovHayley M. Webb, Sophie Regan, Daniel J. Antoine, Nicola Lane, Rachel J. Walsh, Abhishek Srivastava, Philip Starkey‐Lewis, Craig Benson, Dominic P. Williams, Hugh Laverty, Christopher Goldring & B. Kevin Park. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 44 .
Shuai Qian, Siu Kwan Wo & Zhong Zuo. (2012) Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats. Journal of Pharmaceutical and Biomedical Analysis 61, pages 57-63.
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Daniel Silva, Mourad Chioua, Abdelouahid Samadi, M. Carmo Carreiras, María-Luisa Jimeno, Eduarda Mendes, Cristóbal de los Ríos, Alejandro Romero, Mercedes Villarroya, Manuela G. López & José Marco-Contelles. (2011) Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives. European Journal of Medicinal Chemistry 46:9, pages 4676-4681.
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John S. WalshGerald T. Miwa. (2011) Bioactivation of Drugs: Risk and Drug Design. Annual Review of Pharmacology and Toxicology 51:1, pages 145-167.
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Thomas A. Baillie & Allan E. Rettie. (2011) Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism. Drug Metabolism and Pharmacokinetics 26:1, pages 15-29.
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Michael A. Mohutsky, Annette Romeike, Vince Meador, William M. Lee, John Fowler & Sabine Francke-Carroll. (2010) Hepatic Drug-Metabolizing Enzyme Induction and Implications for Preclinical and Clinical Risk Assessment. Toxicologic Pathology 38:5, pages 799-809.
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Jong-Hyuk Sung, Soon-Sun Hong, Sung-Hoon Ahn, Hong Li, Seung-Yong Seo, Chul-Hong Park, Byung-Soon Park & Suk-Jae Chung. (2006) Mechanism for increased bioavailability of tacrine in fasted rats. Journal of Pharmacy and Pharmacology 58:5, pages 643-649.
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Daniel F. Carr, Ana Alfirevic, Jonathan D. Tugwood, Bryan J. Barratt, James Sherwood, John Smith, Munir Pirmohamed & B. Kevin Park. (2007) Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. Pharmacogenetics and Genomics 17:11, pages 961-972.
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John S. Walsh. 2006. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery 49 80 .
Joanna Z. Peng, Rory P. Remmel & Ronald J. Sawchuk. (2004) INHIBITION OF MURINE CYTOCHROME P4501A BY TACRINE: IN VITRO STUDIES. Drug Metabolism and Disposition 32:8, pages 805-812.
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David F.V. Lewis, Brian G. Lake, Stephen G. George, Maurice Dickins, Peter J. Eddershaw, Michael H. Tarbit, Alan P. Beresford, Peter S. Goldfarb & F.Peter Guengerich. (1999) Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102. Toxicology 139:1-2, pages 53-79.
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William Pool. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 577 587 .
Munir Pirmohamed & B Park. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 443 476 .
Errol Zeiger, Gregory Erexson, Kristien Mortelmans & A Thilagar. (1997) Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine). Mutation Research/Genetic Toxicology and Environmental Mutagenesis 393:3, pages 189-197.
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Laurent Becquemont, Isabelle Ragueneau, Marie Annick Le Bot, Christian Riche, Christian Funck-Brentano & Patrice Jaillon. (1997) Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans*. Clinical Pharmacology & Therapeutics 61:6, pages 619-627.
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T. F. Woolf, W. P. Pool, R. M. Walker & D. K. Monteith. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 395 410 .
B.Kevin Park, Munir Pirmohamed & Neil R. Kitteringham. (1995) The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacology & Therapeutics 68:3, pages 385-424.
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