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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 2
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Original Article

Comparison of the disposition of two novel combined thromboxane synthase inhibitors/thromboxane A2 receptor antagonists in the isolated perfused rat liver

I. B. Gardner University Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
,
D. K. Walker Department of Drug Metabolism, Pfizer Central Research, Sandwich, CT13 9NJ, UK
,
M. S. Lennard University Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
,
D. A. Smith University Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
&
G. T. Tucker University Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
Pages 185-197 | Received 14 Sep 1994, Published online: 27 Aug 2009

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Katherine S. Fenner, Hannah M. Jones, Mohammed Ullah, Sarah Kempshall, Maurice Dickins, Yurong Lai, Paul Morgan & Hugh A. Barton. (2012) The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance. Xenobiotica 42:1, pages 28-45.
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Neil Attkins, Alison Betts, David Hepworth & Anne C. Heatherington. (2010) Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human. Xenobiotica 40:11, pages 730-742.
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N. J. Attkins, A. C. Heatherington, J. Phipps, H. Verrier & I. Huyghe. (2009) Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061. Xenobiotica 39:7, pages 523-533.
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A. Ayrton & P. Morgan. (2008) Role of transport proteins in drug discovery and development: a pharmaceutical perspective. Xenobiotica 38:7-8, pages 676-708.
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G. Allan, J. Davis, M. Dickins, I. Gardner, T. Jenkins, H. Jones, R. Webster & H. Westgate. (2008) Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man. Xenobiotica 38:6, pages 620-640.
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G. A. Allan, J. I. Gedge, A. N. R. Nedderman, S. J. Roffey, H. F. Small & R. Webster. (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity. Xenobiotica 36:5, pages 399-418.
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A. Ayrton & P. Morgan. (2001) Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31:8-9, pages 469-497.
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R. Webster, J. Taberner, A. Edgington, S. Guhan, J. Varghese, H. Feeney, L. Blocker & S. G. Jezequel. (1999) Role of sialylation in determining the pharmacokinetics of neutrophil inhibitory factor (NIF) in the Fischer 344 rat. Xenobiotica 29:11, pages 1141-1155.
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Articles from other publishers (10)

Yurong Lai. 2013. Transporters in Drug Discovery and Development. Transporters in Drug Discovery and Development 675 718 .
. 2012. Pharmacokinetics and Metabolism in Drug Design. Pharmacokinetics and Metabolism in Drug Design 209 227 .
. 2012. Pharmacokinetics and Metabolism in Drug Design. Pharmacokinetics and Metabolism in Drug Design 81 102 .
Olaf Weber, Stefan Willmann, Hilmar Bischoff, Volkhart Li, Alexandros Vakalopoulos, Klemens Lustig, Frank-Thorsten Hafner, Roland Heinig, Carsten Schmeck & Klaus Buehner. (2012) Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling. British Journal of Clinical Pharmacology 73:2, pages 219-231.
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Tonika Bohnert & Liang‐Shang Gan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 91 176 .
Anthony Harrison, Alison Betts, Katherine Fenner, Kevin Beaumont, Alan Edgington, Sarah Roffey, John Davis, Pierre Comby & Paul Morgan. (2004) NONLINEAR ORAL PHARMACOKINETICS OF THE α-ANTAGONIST 4-AMINO-5-(4-FLUOROPHENYL)-6,7-DIMETHOXY-2-[4-(MORPHOLINOCARBONYL)-PERHYDRO-1,4-DIAZEPIN-1-YL]QUINOLINE IN HUMANS: USE OF PRECLINICAL DATA TO RATIONALIZE CLINICAL OBSERVATIONS. Drug Metabolism and Disposition 32:2, pages 197-204.
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Dennis Smith, Esther Schmid & Barry Jones. (2002) Do Drug Metabolism and Pharmacokinetic Departments Make Any Contribution to Drug Discovery?. Clinical Pharmacokinetics 41:13, pages 1005-1019.
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Dennis A Smith & Han van de Waterbeemd. (1999) Pharmacokinetics and metabolism in early drug discovery. Current Opinion in Chemical Biology 3:4, pages 373-378.
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Roger P. DickinsonKevin N. DackClive J. LongJohn Steele. (1997) Thromboxane Modulating Agents. 3. 1 H -Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists . Journal of Medicinal Chemistry 40:21, pages 3442-3452.
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Roger P. Dickinson, Kevin N. Dack & John Steele. (1995) Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.. Bioorganic & Medicinal Chemistry Letters 5:24, pages 3017-3022.
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