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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 2
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Original Article

Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine

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Pages 199-217 | Received 14 Sep 1994, Published online: 27 Aug 2009

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Dominique Pessayre, Bernard Fromenty, Alain Berson, Marie-Anne Robin, Philippe Lettéron, Richard Moreau & Abdellah Mansouri. (2012) Central role of mitochondria in drug-induced liver injury. Drug Metabolism Reviews 44:1, pages 34-87.
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Robert A. Roth & Patricia E. Ganey. (2011) Animal models of idiosyncratic drug-induced liver injury—Current status. Critical Reviews in Toxicology 41:9, pages 723-739.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Yangshun Tang, Qiangen Wu, Frederick A. Beland, Si Chen & Jia-Long Fang. (2020) Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicology in Vitro 62, pages 104669.
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Kerri J. Grove, Shaila Hoque & Patrick J. Rudewicz. (2019) Investigation of amodiaquine localization in liver lobules using matrix-assisted laser desorption/ionization imaging mass spectrometry. Rapid Communications in Mass Spectrometry 33:3, pages 252-258.
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Yongjie Zhang, Nico P. E. Vermeulen & Jan N. M. Commandeur. (2017) Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine. British Journal of Clinical Pharmacology 83:3, pages 572-583.
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