Citations (40)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Jinquan Dong, Shyam B. Karki, Mansi Parikh, Jason C. Riggs & Lian Huang. (2012) Oxidative degradation studies of an oxazolidinone-derived antibacterial agent, RWJ416457, in aqueous solutions. Drug Development and Industrial Pharmacy 38:11, pages 1289-1297.
Read now
Read now
Neal Castagnoli$suffix/text()$suffix/text(), Kay Castagnoli, Géraldine Magnin, Simon Kuttab & Jackie Shang. (2002) STUDIES ON THE OXIDATION OF 1,4-DISUBSTITUTED-1,2,3,6-TETRAHYDROPYRIDINES. Drug Metabolism Reviews 34:3, pages 533-547.
Read now
Read now
Hua Gao & Corwin Hansch. (1996) Qsar of P450 Oxidation: On the Value of Comparing kcat and Km with Kcat/Km. Drug Metabolism Reviews 28:4, pages 513-526.
Read now
Read now
Articles from other publishers (37)
Timo Pöstges & Matthias Lehr. (2023) Metabolism of sumatriptan revisited. Pharmacology Research & Perspectives 11:1.
Crossref
Crossref
Tom M. Nolte, Willie J.G.M. Peijnenburg, Ana B. Rios- Miguel, Ya-nan Zhang & A. Jan Hendriks. (2022) Stoichiometric ratios for biotics and xenobiotics capture effective metabolic coupling to re(de)fine biodegradation. Water Research 217, pages 118333.
Crossref
Crossref
Xiaoqian Zhang, Xiao-Xi Li, Yufang Liu & Yong Wang. (2017) Suicide Inhibition of Cytochrome P450 Enzymes by Cyclopropylamines via a Ring-Opening Mechanism: Proton-Coupled Electron Transfer Makes a Difference. Frontiers in Chemistry 5.
Crossref
Crossref
Xiao-Xi Li, Yong Wang, Qing-Chuan Zheng & Hong-Xing Zhang. (2016) Detoxification of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes: A theoretical investigation. Journal of Inorganic Biochemistry 154, pages 21-28.
Crossref
Crossref
Xiao-Xi Li, Xiaoqian Zhang, Qing-Chuan Zheng & Yong Wang. (2015) Bio-activation of 4-alkyl analogs of 1,4-dihydropyridine mediated by cytochrome P450 enzymes. JBIC Journal of Biological Inorganic Chemistry 20:4, pages 665-673.
Crossref
Crossref
R. Scott Obach. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics
1
41
.
Louise J Walport, Richard J Hopkinson & Christopher J Schofield. (2012) Mechanisms of human histone and nucleic acid demethylases. Current Opinion in Chemical Biology 16:5-6, pages 525-534.
Crossref
Crossref
Alexander V. LyubimovRobert S. Foti, Dan A. Rock, Larry C. Wienkers & Jan L. Wahlstrom. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
68
.
Min Li. 2012. Organic Chemistry of Drug Degradation. Organic Chemistry of Drug Degradation
48
109
.
Renata A. Kwiecień, Jean-Yves Le Questel, Jacques Lebreton, Marcel Delaforge, François André, Emilie Pihan, Anaïs Roussel, Anaïs Fournial, Piotr Paneth & Richard J. Robins. (2012)
Cytochrome P450-Catalyzed Degradation of Nicotine: Fundamental Parameters Determining Hydroxylation by Cytochrome P450 2A6 at the 5′-Carbon or the
N
-Methyl Carbon
. The Journal of Physical Chemistry B 116:27, pages 7827-7840.
Crossref
Crossref
Dongmei Li, Yong Wang & Keli Han. (2012) Recent density functional theory model calculations of drug metabolism by cytochrome P450. Coordination Chemistry Reviews 256:11-12, pages 1137-1150.
Crossref
Crossref
Renata A. Kwiecień, Roland Molinié, Piotr Paneth, Virginie Silvestre, Jacques Lebreton & Richard J. Robins. (2011) Elucidation of the mechanism of N-demethylation catalyzed by cytochrome P450 monooxygenase is facilitated by exploiting nitrogen-15 heavy isotope effects. Archives of Biochemistry and Biophysics 510:1, pages 35-41.
Crossref
Crossref
Yong Wang, Dongmei Li, Keli Han & Sason Shaik. (2010)
An Acyl Group Makes a Difference in the Reactivity Patterns of Cytochrome P450 Catalyzed
N
-Demethylation of Substituted
N
,
N
-Dimethylbenzamides—High Spin Selective Reactions
. The Journal of Physical Chemistry B 114:8, pages 2964-2970.
Crossref
Crossref
Sason Shaik, Shimrit Cohen, Yong Wang, Hui Chen, Devesh Kumar & Walter Thiel. (2009) P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations. Chemical Reviews 110:2, pages 949-1017.
Crossref
Crossref
Chunsen Li, Wei Wu, Kyung‐Bin Cho & Sason Shaik. (2009) Oxidation of Tertiary Amines by Cytochrome P450—Kinetic Isotope Effect as a Spin‐State Reactivity Probe. Chemistry – A European Journal 15:34, pages 8492-8503.
Crossref
Crossref
Dongmei Li, Yong Wang, Chuanlu Yang & Keli Han. (2009) Theoretical study of N-dealkylation of N-cyclopropyl-N-methylaniline catalyzed by cytochrome P450: insight into the origin of the regioselectivity. Dalton Trans.:2, pages 291-297.
Crossref
Crossref
Yong Wang, Devesh Kumar, Chuanlu Yang, Keli Han & Sason Shaik. (2007)
Theoretical Study of
N
-Demethylation of Substituted
N,N
-Dimethylanilines by Cytochrome P450: The Mechanistic Significance of Kinetic Isotope Effect Profiles
. The Journal of Physical Chemistry B 111:26, pages 7700-7710.
Crossref
Crossref
Roland Molinié, Renata A. Kwiecień, Piotr Paneth, Wilfried Hatton, Jacques Lebreton & Richard J. Robins. (2007) Investigation of the mechanism of nicotine demethylation in Nicotiana through 2H and 15N heavy isotope effects: Implication of cytochrome P450 oxidase and hydroxyl ion transfer. Archives of Biochemistry and Biophysics 458:2, pages 175-183.
Crossref
Crossref
W.F. Trager. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
87
132
.
Matthew A. Cerny & Robert P. Hanzlik. (2006)
Cytochrome P450-Catalyzed Oxidation of
N
-Benzyl-
N
-cyclopropylamine Generates Both Cyclopropanone Hydrate and 3-Hydroxypropionaldehyde via Hydrogen Abstraction, Not Single Electron Transfer
. Journal of the American Chemical Society 128:10, pages 3346-3354.
Crossref
Crossref
Mehul N. Bhakta & Kandatege Wimalasena. (2005) A Mechanistic Comparison between Cytochrome P450- and Chloroperoxidase-CatalyzedN-Dealkylation ofN,N-Dialkyl Anilines. European Journal of Organic Chemistry 2005:22, pages 4801-4805.
Crossref
Crossref
Philippe Bissel & Neal CastagnoliJr.Jr.. (2005) Studies on the cytochrome P450 catalyzed oxidation of 13C labeled 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine by 13C NMR. Bioorganic & Medicinal Chemistry 13:8, pages 2975-2980.
Crossref
Crossref
Matthew A. Cerny & Robert P. Hanzlik. (2005) Cyclopropylamine inactivation of cytochromes P450: Role of metabolic intermediate complexes. Archives of Biochemistry and Biophysics 436:2, pages 265-275.
Crossref
Crossref
J.Matthew Hutzler, Frank J Powers, Michael A Wynalda & Larry C Wienkers. (2003) Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species. Archives of Biochemistry and Biophysics 417:2, pages 165-175.
Crossref
Crossref
Markus Walles, Thomas Thum, Karsten Levsen & Jürgen Borlak. (2002) Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart. Journal of Chromatography A 970:1-2, pages 117-130.
Crossref
Crossref
Dan A Rock, Anthony E Boitano, Jan L Wahlstrom, Denise A Rock & Jeffrey P Jones. (2002) Use of Kinetic Isotope Effects to Delineate the Role of Phenylalanine 87 in P450BM-3. Bioorganic Chemistry 30:2, pages 107-118.
Crossref
Crossref
Bernard M. Babior. 2002. Reactive Oxygen Species in Biological Systems. Reactive Oxygen Species in Biological Systems
503
526
.
Simon Kuttab, Jackie Shang & Neal CastagnoliJr.Jr.. (2001) Rat liver microsomal enzyme catalyzed oxidation of 4-phenyl-trans-1-(2-phenylcyclopropyl)-1,2,3,6-tetrahydropyridine. Bioorganic & Medicinal Chemistry 9:7, pages 1685-1689.
Crossref
Crossref
J. M. Tanko, Robert Friedline, N. Kamrudin Suleman & Neal Castagnoli. (2001)
tert
-Butoxyl as a Model for Radicals in Biological Systems: Caveat Emptor
. Journal of the American Chemical Society 123:24, pages 5808-5809.
Crossref
Crossref
Hirohisa Nagahori, Hiromi Yoshino, Yoshitaka Tomigahara, Naohiko Isobe, Hideo Kaneko & Iwao Nakatsuka. (2000) Metabolism of Furametpyr. 1. Identification of Metabolites and in Vitro Biotransformation in Rats and Humans. Journal of Agricultural and Food Chemistry 48:11, pages 5754-5759.
Crossref
Crossref
D. R. Adams, M. Brochwicz-Lewinski & A. R. ButlerD. R. Adams, M. Brochwicz-Lewinski & A. R. Butler. 1999. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products
1
186
.
Zhiyang Zhao, Stéphane Mabic, Simon Kuttab, Christelle Franot, Kay Castagnoli & Neal CastagnoliJr.Jr.. (1998) Rat liver microsomal enzyme catalyzed oxidation of 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine. Bioorganic & Medicinal Chemistry 6:12, pages 2531-2539.
Crossref
Crossref
Xiangming Guan, Michael B Fisher, Dieter H Lang, Yi-Min Zheng, Dennis R Koop & Allan E Rettie. (1998) Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid. Chemico-Biological Interactions 110:1-2, pages 103-121.
Crossref
Crossref
Laren M. Tolbert, Zhaozhao Li, Sarath R. Sirimanne & Donald G. VanDerveer. (1997) Chemistry of Arylalkyl Radical Cations: Deprotonation vs Nucleophilic Attack. The Journal of Organic Chemistry 62:12, pages 3927-3930.
Crossref
Crossref
John I. Manchester, Joseph P. Dinnocenzo, Higgins & Jeffrey P. Jones. (1997) A New Mechanistic Probe for Cytochrome P450: An Application of Isotope Effect Profiles. Journal of the American Chemical Society 119:21, pages 5069-5070.
Crossref
Crossref
F. Peter Guengerich, Chul-Ho Yun & Timothy L. Macdonald. (1996) Evidence for a 1-Electron Oxidation Mechanism in N-Dealkylation of N,N-Dialkylanilines by Cytochrome P450 2B1. Journal of Biological Chemistry 271:44, pages 27321-27329.
Crossref
Crossref
Masanori Sono, Mark P. Roach, Eric D. Coulter & John H. Dawson. (1996) Heme-Containing Oxygenases. Chemical Reviews 96:7, pages 2841-2888.
Crossref
Crossref