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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 8
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Research Article

Induction of hepatic microsomal P450 by 4-phenylalkylpyridines in rat: chain length-dependent and sex-related differential induction of P450s

Y. Kobayashi Showa College of Pharmaceutical Sciences, 3165, 3-chome, Higashitamagawagakuen, Machida-shi, Tokyo, 194, Japan
,
T. Yoshida Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142, Japan
,
E. Kotani Showa College of Pharmaceutical Sciences, 3165, 3-chome, Higashitamagawagakuen, Machida-shi, Tokyo, 194, Japan
,
Y. Matsuura Showa College of Pharmaceutical Sciences, 3165, 3-chome, Higashitamagawagakuen, Machida-shi, Tokyo, 194, Japan
,
H. Egawa Showa College of Pharmaceutical Sciences, 3165, 3-chome, Higashitamagawagakuen, Machida-shi, Tokyo, 194, Japan
,
T. Aoyagi Showa College of Pharmaceutical Sciences, 3165, 3-chome, Higashitamagawagakuen, Machida-shi, Tokyo, 194, Japan
,
S. Imaoka Laboratory of Chemistry, Osaka City University Medical School, 1-4-54, Asahimachi, Abeno-ku, Osaka, 545, Japan
,
Y. Funae Laboratory of Chemistry, Osaka City University Medical School, 1-4-54, Asahimachi, Abeno-ku, Osaka, 545, Japan
,
S. Tobinaga Showa College of Pharmaceutical Sciences, 3165, 3-chome, Higashitamagawagakuen, Machida-shi, Tokyo, 194, Japan
&
Y. Kuroiwa Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142, Japan
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Pages 779-789 | Received 23 Jan 1995, Published online: 22 Sep 2008

Citations (6)

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Y. Kobayashi, N. Ohshiro, E. Okui, T. Sasaki, S. Tokuyama, T. Yoshida & T. Yamamoto. (2000) Concurrent induction of rat hepatic microsomal cytochrome P450 and haem oxygenase by 2,2'-dipyridyl ketone: comparison with the effect of 2,2'-dipyridyl amine. Xenobiotica 30:7, pages 683-692.
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Articles from other publishers (5)

Takemi Yoshida, Takashi Ashino & Yasuna Kobayashi. (2016) Chemical-induced coordinated and reciprocal changes in heme metabolism, cytochrome P450 synthesis and others in the liver of humans and rodents. The Journal of Toxicological Sciences 41:Special, pages SP89-SP103.
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Yasuna Kobayashi, Michiya Suzuki, Naomi Ohshiro, Takashi Sunagawa, Tadanori Sasaki, Takiko Oguro, Shogo Tokuyama, Toshinori Yamamoto & Takemi Yoshida. (2002) Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole.. Biological and Pharmaceutical Bulletin 25:1, pages 53-57.
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Yasuna KOBAYASHI, Michiya SUZUKI, Naomi OHSHIRO, Takashi SUNAGAWA, Tadanori SASAKI, Shogo TOKUYAMA, Toshinori YAMAMOTO & Takemi YOSHIDA. (2001) Climbazole is a new potent inducer of rat hepatic cytochrome P450.. The Journal of Toxicological Sciences 26:3, pages 141-150.
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Yasuna KOBAYASHI, Naomi OHSHIRO, Tadanori SASAKI, Shogo TOKUYAMA, Takashi TOBE, Takemi YOSHIDA & Toshinori YAMAMOTO. (2001) Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro.. Biological and Pharmaceutical Bulletin 24:5, pages 505-509.
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Shoji Kudo & Kenji Kawano. (1999) Role of Interleukin-1beta in the Modulations of Cytochrome P450 and Heme Metabolism in Rat Liver. Journal of Interferon & Cytokine Research 19:6, pages 601-607.
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