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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 10
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Research Article

Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans

E. B. Hansen Department of Health and Human Services, Food and Drug Administration, Divisions of Chemistry, National Center for Toxicological Research, Jefferson, AR, 72079, USA
,
B. P. Cho Department of Health and Human Services, Food and Drug Administration, Divisions of Chemistry, National Center for Toxicological Research, Jefferson, AR, 72079, USA; Department of Medicinal Chemistry, University of Rhode Island, Kingston, RI, 02881-0809, USA
,
W. A. Korfmacher Department of Health and Human Services, Food and Drug Administration, Divisions of Chemistry, National Center for Toxicological Research, Jefferson, AR, 72079, USA; Department of Drug Metabolism, Schering-Plough Research Institute, Kenilworth, NJ, 07033-0539, USA
&
Carl E. Cerniglia Divisions of Microbiology, National Center for Toxicological Research, Jefferson, AR, 72079, USA
Pages 1081-1092 | Received 01 Apr 1995, Published online: 22 Sep 2008

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Abhilasha Shourie & U. Vijayalakshmi. (2022) Fungal Diversity and Its Role in Mycoremediation. Geomicrobiology Journal 39:3-5, pages 426-444.
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David C Lamb, Michael R Waterman & Bin Zhao. (2013) Streptomyces cytochromes P450: applications in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1279-1294.
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Joanna D. Moody, Thomas M. Heinze & Carl E. Cerniglia. (2001) Fungal Transformation of the Tricyclic Antidepressant Amoxapine: Identification of N-Carbomethoxy Compounds Formed as Artifacts by Phosgene in Chloroform used for the Extraction of Metabolites. Biocatalysis and Biotransformation 19:2, pages 155-161.
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Articles from other publishers (14)

Ming Song, Hongxiang Zhu, Jian Wang, Weizhuo Xu & Wei Xu. (2022) An O-Demethylation Metabolite of Rabeprazole Sulfide by Cunninghamella blakesleeana 3.970 Biotransformation. Catalysts 13:1, pages 15.
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Bishal Pun & S.R. Joshi. 2022. Biomedical Product and Materials Evaluation. Biomedical Product and Materials Evaluation 667 701 .
Darío R. Olicón-Hernández, Jesús González-López & Elisabet Aranda. (2017) Overview on the Biochemical Potential of Filamentous Fungi to Degrade Pharmaceutical Compounds. Frontiers in Microbiology 8.
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Ruina Gao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Annica Tevell Åberg, Helena Löfgren, Ulf Bondesson & Mikael Hedeland. (2010) Structural elucidation of N -oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification . Rapid Communications in Mass Spectrometry 24:10, pages 1447-1456.
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Annica Tevell Åberg, Charlotte Olsson, Ulf Bondesson & Mikael Hedeland. (2009) A mass spectrometric study on meloxicam metabolism in horses and the fungus Cunninghamella elegans, and the relevance of this microbial system as a model of drug metabolism in the horse . Journal of Mass Spectrometry 44:7, pages 1026-1037.
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Sepuri Asha & Maravajhala Vidyavathi. (2009) Cunninghamella – A microbial model for drug metabolism studies – A review. Biotechnology Advances 27:1, pages 16-29.
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Chang-Jun Cha, Daniel R. Doerge & Carl E. Cerniglia. (2001) Biotransformation of Malachite Green by the Fungus Cunninghamella elegans . Applied and Environmental Microbiology 67:9, pages 4358-4360.
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Joanna D. Moody, Donglu Zhang, Thomas M. Heinze & Carl E. Cerniglia. (2000) Transformation of Amoxapine by Cunninghamella elegans . Applied and Environmental Microbiology 66:8, pages 3646-3649.
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Rong-Fu Wang, Wei-Wen Cao, Ashraf A Khan & Carl E Cerniglia. (2000) Cloning, sequencing, and expression in Escherichia coli of a cytochrome P450 gene from Cunninghamella elegans . FEMS Microbiology Letters 188:1, pages 55-61.
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R. Azerad. 1999. Biotransformations. Biotransformations 169 218 .
D ZhangE B HansenJrJrJ DeckT M HeinzeJ B SutherlandC E Cerniglia. (1996) Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans. Applied and Environmental Microbiology 62:9, pages 3477-3479.
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Donglu Zhang, Yifan Yang, Julian E.A Leakey & Carl E Cerniglia. (1996) Phase I and phase II enzymes produced by Cunninghamella elegans for the metabolism of xenobiotics . FEMS Microbiology Letters 138:2-3, pages 221-226.
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David Moore & Lilyann Novak Frazer. (1996) One stop mycology. Mycological Research 100:5, pages 632-640.
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